Phacoemulsification combined with a new ab interno gel... : Journal of Cataract & Refractive Surgery (original) (raw)

Article

Phacoemulsification combined with a new ab interno gel stent to treat open-angle glaucoma: Pilot study

Sheybani, Arsham MD; Lenzhofer, Markus MD; Hohensinn, Melchior MD; Reitsamer, Herbert MD; Ahmed, Iqbal Ike K. MD*

From the Department of Ophthalmology and Visual Sciences (Sheybani), Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA; Department of Ophthalmology (Lenzhofer, Hohensinn, Reitsamer), University Clinic Salzburg/SALK and Paracelsus Medical University (Reitsamer), Salzburg, Austria; Department of Ophthalmology and Vision Sciences (Ahmed), University of Toronto, Toronto, Credit Valley Eye Care (Ahmed), and Trillium Health Partners (Ahmed), Mississauga, Ontario, Canada

*Corresponding author: Iqbal Ike K. Ahmed, MD, Credit Valley Eye Care, 3200 Erin Mills Parkway, Unit 1 Millway Plaza, Mississauga, Ontario L5L 1W8, Canada.

E-mail: [email protected]

Submitted December 12, 2014; revised January 19, 2015; accepted January 25, 2015.

Supported by Aquesys, Inc., Aliso Viejo, California, USA.

Abstract

Purpose

To study the effect on intraocular pressure (IOP) of implanting a new gelatin stent at the time of cataract surgery in the treatment of open-angle glaucoma (OAG).

Setting

Multicenter university and private-practice settings.

Design

Nonrandomized prospective clinical trial.

Methods

The implantation of 2 models of a gelatin stent (Xen140 and Xen63) was performed at the time of cataract surgery without mitomycin-C. Complete success was defined as a postoperative IOP of less than 18 mm Hg and more than a 20% reduction in IOP at 12 months without glaucoma medication. Failure was defined as loss of light perception vision or worse, a need for additional glaucoma surgery, or less than a 20% reduction in the IOP from baseline.

Results

The study included 37 eyes of 37 patients. The mean preoperative IOP was 22.4 mm Hg ± 4.2 (SD) on 2.5 ± 1.4 medication classes. Twelve months postoperatively, the mean IOP was reduced to 15.4 ± 3.0 mm Hg on 0.9 ± 1.0 medication classes (P < .0001). This resulted in a qualified success of 85.3% and a complete success rate off medications of 47.1%. There were no failures.

Conclusion

Cataract surgery combined with implantation of the gelatin stent resulted in a significant reduction in IOP in eyes with OAG.

Financial Disclosure

Dr. Sheybani has received travel reimbursement from Aquesys, Inc. Dr. Ahmed is a paid consultant to Aquesys, Inc. No other author has a financial or proprietary interest in any material or method mentioned.