Biology and Pathology of Trophoblast (original) (raw)
Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.
"Readers who want a more scientific treatise on the wonders of the placenta should peruse Biology and Pathology of Trophoblast...provide succinct yet comprehensive introductions to a number of important immunologic concepts pertinent to the process of placentation and the maintenance of pregnancy. Many interesting facts about placental immunology are shared."
Drucilla J. Robers, M.D., Massachusetts General Hospital, New England Journal of Medicine.
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Contents
Contents
Select Frontmatter
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Select List of contributors
Select List of participants
Select Preface
Prefacepp xi-xiv
- By[ Y. W. (charlie) Loke](/core/search?filters%5BauthorTerms%5D=Y. W. %28charlie%29 Loke&eventCode=SE-AU), University of Cambridge, UK
Select Chair's introduction
Chair's introductionpp 1-2
- By[ Anne McLaren](/core/search?filters%5BauthorTerms%5D=Anne McLaren&eventCode=SE-AU), Wellcome Trust Cancer Research, Cambridge, UK
Select 1 - Trophoblast cell fate specification
1 - Trophoblast cell fate specificationpp 3-14
- By[ James Cross](/core/search?filters%5BauthorTerms%5D=James Cross&eventCode=SE-AU), University of Calgary, Canada
Select 2 - Stem cells: pluripotency and extraembryonic differentiation in the mouse
2 - Stem cells: pluripotency and extraembryonic differentiation in the mousepp 15-32
- By[ Tilo Kunath](/core/search?filters%5BauthorTerms%5D=Tilo Kunath&eventCode=SE-AU), Institute for Stem Cell Research, University of Edinburgh
Select 3 - Epigenetic regulation of trophoblast development
3 - Epigenetic regulation of trophoblast developmentpp 33-45
- By[ P. Hajkova](/core/search?filters%5BauthorTerms%5D=P. Hajkova&eventCode=SE-AU),[ S. E. Erhardt](/core/search?filters%5BauthorTerms%5D=S. E. Erhardt&eventCode=SE-AU),[ M. A. Surani](/core/search?filters%5BauthorTerms%5D=M. A. Surani&eventCode=SE-AU)
Select 4 - Regulation of X-chromosome inactivation in relation to lineage allocation in early mouse embryogenesis
4 - Regulation of X-chromosome inactivation in relation to lineage allocation in early mouse embryogenesispp 46-64
- By[ Neil Brockdorff](/core/search?filters%5BauthorTerms%5D=Neil Brockdorff&eventCode=SE-AU), MRC Clinical Sciences Centre, Imperial College Faculty of Medicine, UK
Select General discussion I
General discussion Ipp 65-73
- By[ Ashley Moffett](/core/search?filters%5BauthorTerms%5D=Ashley Moffett&eventCode=SE-AU), University of Cambridge, UK,[ Charlie Loke](/core/search?filters%5BauthorTerms%5D=Charlie Loke&eventCode=SE-AU), University of Cambridge, UK,[ Anne McLaren](/core/search?filters%5BauthorTerms%5D=Anne McLaren&eventCode=SE-AU), Cancer Research, Cambridge, UK
Select 5 - Gestational trophoblastic disease
5 - Gestational trophoblastic diseasepp 74-110
- By[ R. A. Fisher](/core/search?filters%5BauthorTerms%5D=R. A. Fisher&eventCode=SE-AU),[ N. J. Sebire](/core/search?filters%5BauthorTerms%5D=N. J. Sebire&eventCode=SE-AU)
Select 6 - Trophoblast and the first trimester environment
6 - Trophoblast and the first trimester environmentpp 111-131
- By[ Graham J. Burton](/core/search?filters%5BauthorTerms%5D=Graham J. Burton&eventCode=SE-AU),[ Eric Jauniaux](/core/search?filters%5BauthorTerms%5D=Eric Jauniaux&eventCode=SE-AU)
Select 7 - Implantation is a sticky situation
7 - Implantation is a sticky situationpp 132-147
- By[ Olga Genbacev](/core/search?filters%5BauthorTerms%5D=Olga Genbacev&eventCode=SE-AU),[ Akraporn Prakobphol](/core/search?filters%5BauthorTerms%5D=Akraporn Prakobphol&eventCode=SE-AU),[ Russell A. Foulk](/core/search?filters%5BauthorTerms%5D=Russell A. Foulk&eventCode=SE-AU),[ Susan J. Fisher](/core/search?filters%5BauthorTerms%5D=Susan J. Fisher&eventCode=SE-AU)
Select 8 - Trophoblast regulation of maternal endocrine function and behaviour
8 - Trophoblast regulation of maternal endocrine function and behaviourpp 148-168
- By[ E. B. Keverne](/core/search?filters%5BauthorTerms%5D=E. B. Keverne&eventCode=SE-AU), University of Cambridge, UK
Select General discussion II
General discussion IIpp 169-172
- By[ Ashley Moffett](/core/search?filters%5BauthorTerms%5D=Ashley Moffett&eventCode=SE-AU), University of Cambridge, UK,[ Charlie Loke](/core/search?filters%5BauthorTerms%5D=Charlie Loke&eventCode=SE-AU), University of Cambridge, UK,[ Anne McLaren](/core/search?filters%5BauthorTerms%5D=Anne McLaren&eventCode=SE-AU), Cancer Research, Cambridge, UK
Select 9 - Molecular signalling in embryo–uterine interactions during implantation
9 - Molecular signalling in embryo–uterine interactions during implantationpp 173-193
- By[ S. K. Dey](/core/search?filters%5BauthorTerms%5D=S. K. Dey&eventCode=SE-AU), Vanderbilt University Medical Center, USA,[ Susanne Tranguch](/core/search?filters%5BauthorTerms%5D=Susanne Tranguch&eventCode=SE-AU), Vanderbilt University Medical Center, USA
Select 10 - Trophoblast and pre-eclampsia
10 - Trophoblast and pre-eclampsiapp 194-222
- By[ C. W. G. Redman](/core/search?filters%5BauthorTerms%5D=C. W. G. Redman&eventCode=SE-AU), Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK,[ I. L. Sargent](/core/search?filters%5BauthorTerms%5D=I. L. Sargent&eventCode=SE-AU), Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK,[ E .A. Linton](/core/search?filters%5BauthorTerms%5D=E .A. Linton&eventCode=SE-AU), Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
Select 11 - Trophoblast and uterine mucosal leukocytes
11 - Trophoblast and uterine mucosal leukocytespp 223-241
- By[ Ashley Moffett](/core/search?filters%5BauthorTerms%5D=Ashley Moffett&eventCode=SE-AU), University of Cambridge, UK
Select 12 - Immunology of trophoblast: a reappraisal
12 - Immunology of trophoblast: a reappraisalpp 242-260
- By[ Y. W. (charlie) Loke](/core/search?filters%5BauthorTerms%5D=Y. W. %28charlie%29 Loke&eventCode=SE-AU), University of Cambridge, UK
Select Final general discussion
Final general discussionpp 261-266
- By[ Ashley Moffett](/core/search?filters%5BauthorTerms%5D=Ashley Moffett&eventCode=SE-AU), University of Cambridge, UK,[ Charlie Loke](/core/search?filters%5BauthorTerms%5D=Charlie Loke&eventCode=SE-AU), University of Cambridge, UK,[ Anne McLaren](/core/search?filters%5BauthorTerms%5D=Anne McLaren&eventCode=SE-AU), Cancer Research, Cambridge, UK
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