Biology and Pathology of Trophoblast (original) (raw)

Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.

"Readers who want a more scientific treatise on the wonders of the placenta should peruse Biology and Pathology of Trophoblast...provide succinct yet comprehensive introductions to a number of important immunologic concepts pertinent to the process of placentation and the maintenance of pregnancy. Many interesting facts about placental immunology are shared."
Drucilla J. Robers, M.D., Massachusetts General Hospital, New England Journal of Medicine.

Contents

Contents

Select Frontmatter

Select Contents

Select List of contributors

Select List of participants

Select Preface

Select Chair's introduction

Select 1 - Trophoblast cell fate specification

Select 2 - Stem cells: pluripotency and extraembryonic differentiation in the mouse

Select 3 - Epigenetic regulation of trophoblast development

Select 4 - Regulation of X-chromosome inactivation in relation to lineage allocation in early mouse embryogenesis

Select General discussion I

Select 5 - Gestational trophoblastic disease

Select 6 - Trophoblast and the first trimester environment

Select 7 - Implantation is a sticky situation

Select 8 - Trophoblast regulation of maternal endocrine function and behaviour

Select General discussion II

Select 9 - Molecular signalling in embryo–uterine interactions during implantation

Select 10 - Trophoblast and pre-eclampsia

Select 11 - Trophoblast and uterine mucosal leukocytes

Select 12 - Immunology of trophoblast: a reappraisal

Select Final general discussion

Select Index

Select Plate section

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