‘Nude’, a new hairless gene with pleiotropic effects in the mouse | Genetics Research | Cambridge Core (original) (raw)

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1. Nude is a new recessive gene causing hairlessness in the mouse. It is linked to rex and trembler in linkage group VII. The order of the three loci and the recombination frequencies are as follows:

2. In addition to hairlessness the new gene causes reduced body growth rate, very low fertility and a liver disease causing death. Nude mice may be classified at birth by the absence of vibrissae.

3. The hairlessness is due to abnormal keratinization of hair in the follicles. The skin histology resembles that of naked mice. The hair follicles were found to be deficient in free sulphydryl groups.

4. The majority of nude mice die of general body weakness within 2 weeks of birth. The survivors grow slowly and may live for a considerable period. But all nude mice eventually die, usually between 3 and 14 weeks of age.

5. The livers of dead or moribund nude mice are covered with lesions and scars. The defect has been traced histologically to its initial stage, namely, necrosis of small areas of tissue.

6. Attempts to relate the deficiency of sulphydryl groups in the hair follicles to abnormal sulphur metabolism in the liver were unsuccessful.

7. Pseudo-cysts of a parasitic protozoan, Toxoplasma gondii, were identified in the liver and brain of nude mice. In one case the free form of the organism was found.

8. The possible relationship between the liver disease and the pathogenic organism is discussed.

Type

Research Article

Copyright

Copyright © Cambridge University Press 1966

References

Bennett, H. S. (1951). The demonstration of thiol groups in certain tissues by means of a new coloured sulphydryl reagent. Anat. Bee. 110, 231.Google Scholar

Carter, T. C. & Falconer, D. S. (1951). Stocks for detecting linkage in the mouse and the theory of their design. J. Genet. 50, 307–323.CrossRefGoogle ScholarPubMed

David, L. T. (1932). The external expression and comparative dermal histology of hereditary hairlessness in mammals. Z. Zellforsch. mikrosk. Anat. 14, 616–719.CrossRefGoogle Scholar

Eisen, A. Z., Montagna, W. & Chase, H. B. (1953). Sulphydryl groups in the skin of the mouse and guinea pig. J. natn. Cancer Inst. 14, 341–348.CrossRefGoogle ScholarPubMed

Falconer, D. S., Fraser, A. S. & King, J. W. B. (1951). The genetics and development of crinkled, a new mutant in the house mouse. J. Genet. 50, 324–344.CrossRefGoogle ScholarPubMed

Falconer, D. S. & Sobey, W. R. (1953). The location of Trembler in linkage group VII in the house mouse. J. Hered. 44, 159.CrossRefGoogle Scholar

Feldman, H. A. (1953). The clinical manifestation and laboratory diagnosis of Toxoplasmosis. Am. J. Trop. Med. Hyg. 2, 420–428.CrossRefGoogle ScholarPubMed

Fraser, F. C. (1946). The expression and interaction of factors producing hypotrichosis in the house mouse; histology and experimental results. Can. J. Res. D, 24, 10–25.CrossRefGoogle ScholarPubMed

Frenkel, J. K. (1953). Host, strain and treatment variation as factors in the pathogenesis of Toxoplasmosis. Am. J. trop Med. Hyg. 2, 390–415CrossRefGoogle ScholarPubMed

Giroud, A. & Bulliard, H. (1930). La keratinization de l'epiderme et de phanares. Genesa des substances soufrees de la keratins. Archs. Morph. gin. exp. 29, 1–83.Google Scholar

Glynn, L. E., Himsworth, H. P. & Neuberger, A. (1945). Pathological states due to deficiency of the sulphur containing amino acids. Br. J. exp. Path. 26, 326.Google Scholar

Grüneberg, H. (1943). Congenital hydrocephalus in the mouse, a case of spurious pleio-tropism. J. Genet. 45, 1–21.CrossRefGoogle Scholar

Long, C. (1961). Biochemists Handbook. London: Spon, Ltd.Google Scholar

Mescon, H. & Flesch, P. (1952). Modification of Bennett's method for histochemical demonstration of free—SH groups in skin. J. invest. Derm. 18, 261–266.CrossRefGoogle Scholar

Russell, E. S. (1949). Analysis of pleiotropism of the W locus in the mouse; relationship between the effects of W and Wv substitution on hair pigmentation and on erythrocytes. Genetics, 34, 708–723.CrossRefGoogle Scholar

Ryder, M. L. (1958). Investigations into the distribution of thiol groups in the skin follicles of mice and sheep and the entry of labelled sulphur compounds. Proc. B. Soc. Edinb. (B) LXVII (I), P. 65.Google Scholar

Slee, J. (1957). The morphology and development of Ragged, a mutant affecting the skin and hair of the house mouse. I. Adult morphology. J. Genet. 55, 100–121.CrossRefGoogle Scholar