I.—On the Developmental Processes in Mammary Glands and other Epidermal Structures | Earth and Environmental Science Transactions of The Royal Society of Edinburgh | Cambridge Core (original) (raw)

Synopsis:

The early development of the mammary glands and of hair follicles in the mouse and the rabbit has been investigated by means of mitotic counts, by histochemical methods and by cultivation in vitro. In the first stage of the formation of both types of rudiment a thickening of the epidermis appears as a consequence of an aggregation of cells, not of a local elevation of the mitotic rate. During this stage alkaline phosphatase is absent from the cells and the content of ribose-nucleic acid reduced. Both these substances appear in higher concentrations later, and their relation to processes of growth and differentiation is discussed. Essentially similar phenomena are found in rudiments cultivated in vitro, which, however, frequently suffer a degeneration by a process of keratinisation.

References

Balinsky, B. I., 1950. “On the Prenatal Growth of the Mammary-Gland Rudiment in the Mouse”, Journ. Anat., LXXXIV.Google Scholar

Brachet, J., 1941. “La localisation des acides pentosenucléiques dans les tissus animaux at les oeufs d'Amphibiens en voie de développement”, Arch. de Biol., LIII, 207–257., CVI.Google Scholar

Vogt, W., 1929. “Gestaltungsanalyse am Amphibienkeim mit örtlicher Vitalfärbung. II Teil. Gastrulation und Mesodermbildung bei Urodelen und Anuren”, Roux' Archiv., CXX, 384–706.CrossRefGoogle Scholar

Woodard, T. M. jun., 1948. “The Mitotic Index in the Chick Embryo”, Amer. Nat., LXXXII, 129–136.CrossRefGoogle Scholar