Pathology of the Heart in Friedreich's Ataxia: Review of the Literature and Report of One Case | Canadian Journal of Neurological Sciences | Cambridge Core (original) (raw)

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A single case of typical Friedreich's ataxia was analyzed for cardiac changes and compared to the findings from the literature. Macroscopically, there was a cardiomegaly with some degree of ventricular hypertrophy and probable mild dilatation of the auricles. The more important and constant histologic changes were myocardial fibrosis and degeneration of the cardiac muscle cells. Granular deposits of calcium salts and iron were found in the muscle cells. A cardiomyopathy hypertrophic in type and occasionally obstructive appears to be an integral part of Friedreich's ataxia.

Type

Quebec Cooperative Study of Friedreich's Ataxia

Copyright

Copyright © Canadian Neurological Sciences Federation 1976

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