Electrophysiological estimates of visual sensitivity in albino and pigmented mice | Visual Neuroscience | Cambridge Core (original) (raw)

Abstract

We have estimated the absolute threshold of congenic albino and pigmented mice (C57) using ERG, pupillary light reflex, and VHP. We are unable to detect strain differences using ERGs or VEPs, but pupillary thresholds appear to be different. In addition, as we have previously reported for rats, VEP thresholds are considerably lower than the ERG b−wave thresholds. The VEP thresholds agree with behavioral data from pigmented mice made by others. The mouse VEP thresholds are close to the VEP thresholds in rats and the psychophysical thresholds of two human observers.

Type

Research Articles

Copyright

Copyright © Cambridge University Press 1994

References

Balkema, G.W. (1988). Elevated dark-adapted thresholds in albino rodents. Investigative Ophthalmology and Visual Science 29, 544–549.Google ScholarPubMed

Balkema, G.W. & Drager, U.C. (1991). Impaired visual thresholds in hypopigmented animals. Visual Neuroscience 6, 577–585.CrossRefGoogle ScholarPubMed

Balkema, G.W., Mangini, N.J., Pinto, L.H. & Vanable, J.W. Jr., (1984). Visually evoked eye movements in mouse mutants and inbred strains. Investigative Ophthalmology and Visual Science 25, 795–800.Google ScholarPubMed

Balkema, G.W. & Pinto, L.H. (1982). Electrophysiology of retinal ganglion cells in the mouse: A study of a normally pigmented mouse and a congenic hypopigmentation mutant pearl. Journal of Neurophysiology 48, 968–980.CrossRefGoogle Scholar

Balkema, G.W., Pinto, L.H., Drager, U.C. & Vanable, J.W. (1981). Characterization of abnormalities in the visual system of the mutant mouse pearl. Journal of Neuroscience 1(11), 1320–1329.CrossRefGoogle ScholarPubMed

Campbell, F.W. & Kulikowski, J.J. (1972). The visual evoked potential as a function of contrast sensitivity of a grating pattern. Journal of Physiology 222, 345–356.CrossRefGoogle Scholar

Dean, P. (1978). Visual acuity in hooded rats: Effects of superior collicular or posterior neocortical lesions. Brain Research 157, 17–31.CrossRefGoogle Scholar

Defries, J.C., Hegmann, J.P. & Weir, M.W. (1966). Open-field behavior in mice: Evidence for a major gene effect mediated by the visual system. Science 154, 1577–1579.CrossRefGoogle Scholar

Drager, V.C. & Olsen, J.F. (1980). Origins of crossed and uncrossed retinal projections in pigmented and albino mice. Journal of Comparative Neurology 191, 383–412.CrossRefGoogle ScholarPubMed

Dreher, B., Sefton, A.J., Ni, S.Y. & Nisbett, G. (1985). The morphology, number, distribution and central projections of Class I retinal ganglion cells in albino and hooded rats. Brain, Behavior, and Evolution 26, 10–48.Google Scholar

Green, D.G., Herreros De Tejada, P. & Glover, M.J. (1991). Are albino rats night blind? Investigative Ophthalmology and Visual Science 32, 2366–2371.Google ScholarPubMed

Hayes, J.M. & Balkema, G.W. (1993). Elevated dark-adapted thresholds in hypopigmented mice measured with a water maze screening apparatus. Behavior Genetics 23, 395–403.CrossRefGoogle ScholarPubMed

Herreros De Tejada, P., Green, D.G. & Muñoz Tedó, C. (1992). Visual thresholds in albino and pigmented rats. Visual Neuroscience 9, 409–414.CrossRefGoogle ScholarPubMed

La Vail, J.H., Nixon, R. & Sidman, R.L. (1978). Genetic control of retinal ganglion cell projections. Journal of Comparative Neurology 182, 399–421.CrossRefGoogle ScholarPubMed

Legg, C.R. (1986). Spatial contrast and flicker sensitivity following medial talamic or visual cortex lesion in hooded rats. Behavioral Brain Research 19, 41–47.CrossRefGoogle ScholarPubMed

Montero, V.M., Rojas, A. & Torrealba, F. (1973). Retinotopic organization of striate and prestriate visual cortex in the albino rat. Brain Research 53, 197–201.CrossRefGoogle Scholar

Muñoz Tedó, C., Herreros De Tejada, P. & Green, D.G. (1994). Behavioral estimates of absolute threshold in rat. Visual Neuroscience (in press).Google Scholar

Overton, P., Dean, P. & Redgrave, P. (1985). Detection of visual stimuli in far periphery by rats: Possible role of superior colliculus. Experimental Brain Research 59, 559–569.CrossRefGoogle ScholarPubMed

Paylor, R., Baskall, L. & Wehner, J.M. (1993). Behavioral dissociations between C57 BL/6 and DBA/Z mice on learning and memory tasks: A Hippocampal-disfunction hypothesis. Psychobiology 21(1), 11–26.CrossRefGoogle Scholar

Santucci, A.C. & Treichler, F.R. (1985). Effect of posterior cortical lesion on two versions of the brightness-discrimination task. Physiological Psychology 13(2), 86–91.CrossRefGoogle Scholar

Trejo, L.J. & Cicerone, C.M. (1982). Retinal sensitivity measured by the pupillary light reflex in RCS and albino rats. Vision Research 22, 1163–1171.CrossRefGoogle ScholarPubMed

Upchurch, M. & Wehner, J.M. (1988). Differences between inbred strains of mice in Morris water maze performance. Behavior Genetics 18, 55–68.CrossRefGoogle ScholarPubMed