Glial cell inclusions and the pathogenesis of neurodegenerative diseases | Neuron Glia Biology | Cambridge Core (original) (raw)
Hostname: page-component-745bb68f8f-b6zl4 Total loading time: 0 Render date: 2025-01-12T12:07:27.122Z Has data issue: false hasContentIssue false
Published online by Cambridge University Press: 05 May 2004
DAVID W. MILLER
Affiliation:
Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda MD 20892-1589
MARK R. COOKSON
Affiliation:
Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda MD 20892-1589
DENNIS W. DICKSON
Affiliation:
Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224
Abstract
In this review, we discuss examples that show how glial-cell pathology is increasingly recognized in several neurodegenerative diseases. We also discuss the more provocative idea that some of the disorders that are currently considered to be neurodegenerative diseases might, in fact, be due to primary abnormalities in glia. Although the mechanism of glial pathology (i.e. modulating glutamate excitotoxicity) might be better established for amyotrophic lateral sclerosis (ALS), a role for neuronal–glial interactions in the pathogenesis of most neurodegenerative diseases is plausible. This burgeoning area of neuroscience will receive much attention in the future and it is expected that further understanding of basic neuronal–glial interactions will have a significant impact on the understanding of the fundamental nature of human neurodegenerative disorders.
Keywords
Type
Research Article
Copyright
© Cambridge University Press 2004
Access options
Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)