The current state of play on the molecular genetics of depression | Psychological Medicine | Cambridge Core (original) (raw)

References

Abkevich, V, Camp, NJ, Hensel, CH, Neff, CD, Russell, DL, Hughes, DC, Plenk, AM, Lowry, MR, Richards, RL, Carter, C, Frech, GC, Stone, S, Rowe, K, Chau, CA, Cortado, K, Hunt, A, Luce, K, O'Neil, G, Poarch, J, Potter, J, Poulsen, GH, Saxton, H, Bernat-Sestak, M, Thompson, V, Gutin, A, Skolnick, MH, Shattuck, D, Cannon-Albright, L (2003). Predisposition locus for major depression at chromosome 12q22-12q23.2. American Journal of Human Genetics 73, 1271–1281.CrossRefGoogle Scholar

Anguelova, M, Benkelfat, C, Turecki, G (2003). A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Molecular Psychiatry 8, 646–653.CrossRefGoogle ScholarPubMed

Battersby, S, Ogilvie, AD, Smith, CA, Blackwood, DH, Muir, WJ, Quinn, JP, Fink, G, Goodwin, GM, Harmar, AJ (1996). Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatric Genetics 6, 177–181.CrossRefGoogle ScholarPubMed

Baune, BT, Hohoff, C, Mortensen, LS, Deckert, J, Arolt, V, Domschke, K (2008). Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect? Depression and Anxiety 25, 920–925.CrossRefGoogle ScholarPubMed

Bonvicini, C, Minelli, A, Scassellati, C, Bortolomasi, M, Segala, M, Sartori, R, Giacopuzzi, M, Gennarelli, M (2010). Serotonin transporter gene polymorphisms and treatment-resistant depression. Progress in Neuropsychopharmacology and Biological Psychiatry 34, 934–939.CrossRefGoogle ScholarPubMed

Bozina, N, Mihaljevic-Peles, A, Sagud, M, Jakovljevic, M, Sertic, J (2006). Serotonin transporter polymorphism in Croatian patients with major depressive disorder. Psychiatria Danubina 18, 83–89.Google ScholarPubMed

Breen, G, Webb, BT, Butler, A, van den Oord, EJ, Tozzi, F, Craddock, N, Gill, M, Korszun, A, Maier, W, Middleton, L, Holsboer, F, Mors, O, Lucae, S, Owen, MJ, Cohen Woods, S, Perry, J, Galwey, NW, Upmanyu, R, Craig, I, Lewis, C, Ng, M, Brewster, S, Preisig, M, Rietschel, M, Jones, L, Knight, J, Rice, J, Muglia, P, Farmer, AE, McGuffin, P (2011). A genomewide significant linkage for severe depression on chromosome 3: the Depression Network Study. Journal of Psychiatry 168, 840–847.Google ScholarPubMed

Brown, GW (2012). The promoter of the serotonin transporter genotype, environment and depression: a hypothesis supported? Journal of Affective Disorders 137, 1–3.CrossRefGoogle ScholarPubMed

Brummett, BH, Krystal, AD, Siegler, IC, Kuhn, C, Surwit, RS, Zuchner, S, Ashley-Koch, A, Barefoot, JC, Williams, RB (2007). Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosomatic Medicine 69, 396–401.CrossRefGoogle ScholarPubMed

Burcescu, I, Wigg, K, Gomez, L, King, N, Vetro, A, Kiss, E, Kapornai, K, Gadoros, J, Kennedy, JL, Kovacs, M, Barr, CL (2006). Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 141, 227–233.CrossRefGoogle Scholar

Camp, NJ, Lowry, MR, Richards, RL, Plenk, AM, Carter, C, Hensel, CH, Abkevich, V, Skolnick, MH, Shattuck, D, Rowe, KG, Hughes, DC, Cannon-Albright, LA (2005). Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 135B, 85–93.CrossRefGoogle ScholarPubMed

Caspi, A, Sugden, K, Moffitt, TE, Taylor, A, Craig, IW, Harrington, H, McClay, J, Mill, J, Martin, J, Braithwaite, A, Poulton, R (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386–389.CrossRefGoogle ScholarPubMed

Charney, DS, Manji, HK (2004). Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention. Science Signaling 2004, re5.Google ScholarPubMed

Christiansen, L, Tan, Q, Iachina, M, Bathum, L, Kruse, TA, McGue, M, Christensen, K (2007). Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biological Psychiatry 61, 223–230.CrossRefGoogle Scholar

Collier, DA, Stober, G, Li, T, Heils, A, Catalano, M, Di Bella, D, Arranz, MJ, Murray, RM, Vallada, HP, Bengel, D, Muller, CR, Roberts, GW, Smeraldi, E, Kirov, G, Sham, P, Lesch, KP (1996). A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Molecular Psychiatry 1, 453–460.Google ScholarPubMed

Cowen, PJ, Charig, EM (1987). Neuroendocrine responses to intravenous tryptophan in major depression. Archives of General Psychiatry 44, 958–966.CrossRefGoogle ScholarPubMed

Craig, SP, Boularand, S, Darmon, MC, Mallet, J, Craig, IW (1991). Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3-p14 by in situ hybridization. Cytogenetics and Cell Genetics 56, 157–159.CrossRefGoogle ScholarPubMed

Davies, PA, Pistis, M, Hanna, MC, Peters, JA, Lambert, JJ, Hales, TG, Kirkness, EF (1999). The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature 397, 359–363.CrossRefGoogle Scholar

Dikeos, DG, Papadimitriou, GN, Avramopoulos, D, Karadima, G, Daskalopoulou, EG, Souery, D, Mendlewicz, J, Vassilopoulos, D, Stefanis, CN (1999). Association between the dopamine D3 receptor gene locus (DRD3) and unipolar affective disorder. Psychiatric Genetics 9, 189–195.CrossRefGoogle ScholarPubMed

Dong, C, Wong, ML, Licinio, J (2009). Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Molecular Psychiatry 14, 1105–1118.CrossRefGoogle ScholarPubMed

Duman, RS (1999). The neurochemistry of mood disorders: preclinical studies. In Neurobiology of Mental Illness(ed. Charney, D. S., Nestler, E. J. and Bunney, B. S.), pp. 333–347. Oxford University Press: New York.Google Scholar

Eley, TC, Deater-Deckard, K, Fombonne, E, Fulker, DW, Plomin, R (1998). An adoption study of depressive symptoms in middle childhood. Journal of Child Psychology and Psychiatry 39, 337–345.CrossRefGoogle ScholarPubMed

Eley, TC, Sugden, K, Corsico, A, Gregory, AM, Sham, P, McGuffin, P, Plomin, R, Craig, IW (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry 9, 908–915.CrossRefGoogle ScholarPubMed

Fergusson, DM, Horwood, LJ, Miller, AL, Kennedy, MA (2012). Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study. British Journal of Psychiatry 198, 129–135.CrossRefGoogle Scholar

Fisher, H, Cohen-Woods, S, Hosang, G, Korszun, A, Owen, M, Craddock, N, Craig, IW, Farmer, AE, McGuffin, P, Uher, R (in press). Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder. Journal of Affective Disorders.Google Scholar

Fisher, HL, Cohen-Woods, S, Hosang, GM, Uher, R, Powell-Smith, G, Keers, R, Tropeano, M, Korszun, A, Jones, L, Jones, I, Owen, M, Craddock, N, Craig, IW, Farmer, AE, McGuffin, P (2012). Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression. Journal of Affective Disorders 136, 189–193.CrossRefGoogle ScholarPubMed

Frisch, A, Postilnick, D, Rockah, R, Michaelovsky, E, Postilnick, S, Birman, E, Laor, N, Rauchverger, B, Kreinin, A, Poyurovsky, M, Schneidman, M, Modai, I, Weizman, R (1999). Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Molecular Psychiatry 4, 389–392.CrossRefGoogle ScholarPubMed

Fuchs, E, Flugge, G (2003). Chronic social stress: effects on limbic brain structures. Physiology and Behavior 79, 417–427.CrossRefGoogle ScholarPubMed

Furlong, RA, Coleman, TA, Ho, L, Rubinsztein, JS, Walsh, C, Paykel, ES, Rubinsztein, DC (1998 a). No association of a functional polymorphism in the dopamine D2 receptor promoter region with bipolar or unipolar affective disorders. American Journal of Medical Genetics 81, 385–387.3.0.CO;2-S>CrossRefGoogle ScholarPubMed

Furlong, RA, Ho, L, Walsh, C, Rubinsztein, JS, Jain, S, Paykel, ES, Easton, DF, Rubinsztein, DC (1998 b). Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. American Journal of Medical Genetics 81, 58–63.3.0.CO;2-V>CrossRefGoogle ScholarPubMed

Garriock, HA, Delgado, P, Kling, MA, Carpenter, LL, Burke, M, Burke, WJ, Schwartz, T, Marangell, LB, Husain, M, Erickson, RP, Moreno, FA (2006). Number of risk genotypes is a risk factor for major depressive disorder: a case control study. Behavioral and Brain Functions 2, 24.CrossRefGoogle ScholarPubMed

Gizatullin, R, Zaboli, G, Jonsson, EG, Asberg, M, Leopardi, R (2006). Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biological Psychiatry 59, 295–300.CrossRefGoogle ScholarPubMed

Glatt, CE, Carlson, E, Taylor, TR, Risch, N, Reus, VI, Schaefer, CA (2005). Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11–16. Neuron 48, 704–705.CrossRefGoogle Scholar

Glessner, JT, Wang, K, Sleiman, PM, Zhang, H, Kim, CE, Flory, JH, Bradfield, JP, Imielinski, M, Frackleton, EC, Qiu, H, Mentch, F, Grant, SF, Hakonarson, H (2010). Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder. PLoS ONE 5, e15463.CrossRefGoogle ScholarPubMed

Gratacos, M, Gonzalez, JR, Mercader, JM, de Cid, R, Urretavizcaya, M, Estivill, X (2007). Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biological Psychiatry 61, 911–922.CrossRefGoogle ScholarPubMed

Gutierrez, B, Arias, B, Gasto, C, Catalan, R, Papiol, S, Pintor, L, Fananas, L (2004). Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders. Psychiatric Genetics 14, 203–208.CrossRefGoogle ScholarPubMed

Hanson, IM, Seawright, A, van Heyningen, V (1992). The human BDNF gene maps between FSHB and HVBS1 at the boundary of 11p13-p14. Genomics 13, 1331–1333.CrossRefGoogle ScholarPubMed

Harrington, R, Rutter, M, Weissman, M, Fudge, H, Groothues, C, Bredenkamp, D, Pickles, A, Rende, R, Wickramaratne, P (1997). Psychiatric disorders in the relatives of depressed probands. I. Comparison of prepubertal, adolescent and early adult onset cases. Journal of Affective Disorders 42, 9–22.CrossRefGoogle ScholarPubMed

Hauser, J, Leszczynska, A, Samochowiec, J, Czerski, PM, Ostapowicz, A, Chlopocka, M, Horodnicki, J, Rybakowski, JK (2003). Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder. European Psychiatry 18, 129–132.CrossRefGoogle ScholarPubMed

Heils, A, Teufel, A, Petri, S, Stober, G, Riederer, P, Bengel, D, Lesch, KP (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry 66, 2621–2624.CrossRefGoogle ScholarPubMed

Hek, K, Mulder, CL, Luijendijk, HJ, van Duijn, CM, Hofman, A, Uitterlinden, AG, Tiemeier, H (2010). The PCLO gene and depressive disorders: replication in a population-based study. Human Molecular Genetics 19, 731–734.CrossRefGoogle ScholarPubMed

Holmans, P, Weissman, MM, Zubenko, GS, Scheftner, WA, Crowe, RR, DePaulo, Jr. JR, Knowles, JA, Zubenko, WN, Murphy-Eberenz, K, Marta, DH, Boutelle, S, McInnis, MG, Adams, P, Gladis, M, Steele, J, Miller, EB, Potash, JB, Mackinnon, DF, Levinson, DF (2007). Genetics of recurrent early-onset major depression (GenRED): final genome scan report. American Journal of Psychiatry 164, 248–258.CrossRefGoogle ScholarPubMed

Holmans, P, Zubenko, GS, Crowe, RR, DePaulo, Jr. JR, Scheftner, WA, Weissman, MM, Zubenko, WN, Boutelle, S, Murphy-Eberenz, K, MacKinnon, D, McInnis, MG, Marta, DH, Adams, P, Knowles, JA, Gladis, M, Thomas, J, Chellis, J, Miller, E, Levinson, DF (2004). Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q. American Journal of Human Genetics 74, 1154–1167.CrossRefGoogle ScholarPubMed

Huang, YY, Oquendo, MA, Friedman, JM, Greenhill, LL, Brodsky, B, Malone, KM, Khait, V, Mann, JJ (2003). Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. Neuropsychopharmacology 28, 163–169.CrossRefGoogle ScholarPubMed

Inoue, K, Itoh, K, Yoshida, K, Higuchi, H, Kamata, M, Takahashi, H, Shimizu, T, Suzuki, T (2007). No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population. Biological and Pharmaceutical Bulletin 30, 1996–1998.CrossRefGoogle Scholar

Inoue, K, Itoh, K, Yoshida, K, Shimizu, T, Suzuki, T (2004). Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population. Neuropsychobiology 50, 301–304.CrossRefGoogle Scholar

International Schizophrenia Consortium (2008). Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455, 237–241.CrossRefGoogle Scholar

Kaiser, R, Tremblay, PB, Schmider, J, Henneken, M, Dettling, M, Muller-Oerlinghausen, B, Uebelhack, R, Roots, I, Brockmoller, J (2001). Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia. Molecular Psychiatry 6, 179–185.CrossRefGoogle ScholarPubMed

Kao, CF, Jia, P, Zhao, Z, Kuo, PH (2012). Enriched pathways for majore depressive disorder identified from a genome-wide association study. International Journal of Neuropsychopharmacology 16, 1–11.Google Scholar

Karg, K, Burmeister, M, Shedden, K, Sen, S (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Archives of General Psychiatry 68, 444–454.CrossRefGoogle ScholarPubMed

Kendler, KS (1996). Major depression and generalised anxiety disorder. Same genes, (partly)different environments – revisited. British Journal of Psychiatry 168 (Suppl. 30), 68–75.CrossRefGoogle Scholar

Kendler, KS, Karkowski, LM, Prescott, CA (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry 156, 837–841.CrossRefGoogle ScholarPubMed

Kendler, KS, Neale, MC, Kessler, RC, Heath, AC, Eaves, LJ (1993). The lifetime history of major depression in women. Reliability of diagnosis and heritability. Archives of General Psychiatry 50, 863–870.CrossRefGoogle ScholarPubMed

Kessler, R, McGonagle, K, Zhao, S, Nelson, C, Hughes, M, Eshleman, S, Wittchen, H, Kendler, K (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry 51, 8–19.CrossRefGoogle ScholarPubMed

Klimek, V, Stockmeier, C, Overholser, J, Meltzer, HY, Kalka, S, Dilley, G, Ordway, GA (1997). Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. Journal of Neuroscience 17, 8451–8458.CrossRefGoogle ScholarPubMed

Koks, S, Nikopensius, T, Koido, K, Maron, E, Altmae, S, Heinaste, E, Vabrit, K, Tammekivi, V, Hallast, P, Kurg, A, Shlik, J, Vasar, V, Metspalu, A, Vasar, E (2006). Analysis of SNP profiles in patients with major depressive disorder. International Journal of Neuropsychopharmacology 9, 167–174.CrossRefGoogle ScholarPubMed

Kunugi, H, Ishida, S, Kato, T, Tatsumi, M, Sakai, T, Hattori, M, Hirose, T, Nanko, S (1999). A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Molecular Psychiatry 4, 393–395.CrossRefGoogle ScholarPubMed

Kunugi, H, Vallada, HP, Hoda, F, Kirov, G, Gill, M, Aitchison, KJ, Ball, D, Arranz, MJ, Murray, RM, Collier, DA (1997). No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene. Biological Psychiatry 42, 282–285.CrossRefGoogle ScholarPubMed

Lappalainen, J, Zhang, L, Dean, M, Oz, M, Ozaki, N, Yu, DH, Virkkunen, M, Weight, F, Linnoila, M, Goldman, D (1995). Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics 27, 274–279.CrossRefGoogle ScholarPubMed

Lerer, B, Macciardi, F, Segman, RH, Adolfsson, R, Blackwood, D, Blairy, S, Del Favero, J, Dikeos, DG, Kaneva, R, Lilli, R, Massat, I, Milanova, V, Muir, W, Noethen, M, Oruc, L, Petrova, T, Papadimitriou, GN, Rietschel, M, Serretti, A, Souery, D, Van Gestel, S, Van Broeckhoven, C, Mendlewicz, J (2001). Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Molecular Psychiatry 6, 579–585.CrossRefGoogle ScholarPubMed

Lesch, KP, Bengel, D, Heils, A, Sabol, SZ, Greenberg, BD, Petri, S, Benjamin, J, Muller, CR, Hamer, DH, Murphy, DL (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527–1531.CrossRefGoogle ScholarPubMed

Levinson, DF, Evgrafov, OV, Knowles, JA, Potash, JB, Weissman, MM, Scheftner, WA, DePaulo, Jr. JR, Crowe, RR, Murphy-Eberenz, K, Marta, DH, McInnis, MG, Adams, P, Gladis, M, Miller, EB, Thomas, J, Holmans, P (2007). Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers. American Journal of Psychiatry 164, 259–264.CrossRefGoogle ScholarPubMed

Levy, ER, Powell, JF, Buckle, VJ, Hsu, YP, Breakefield, XO, Craig, IW (1989). Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: implications for Norrie disease. Genomics 5, 368–370.CrossRefGoogle ScholarPubMed

Lewis, CM, Ng, MY, Butler, AW, Cohen-Woods, S, Uher, R, Pirlo, K, Weale, ME, Schosser, A, Paredes, UM, Rivera, M, Craddock, N, Owen, MJ, Jones, L, Jones, I, Korszun, A, Aitchison, KJ, Shi, J, Quinn, JP, Mackenzie, A, Vollenweider, P, Waeber, G, Heath, S, Lathrop, M, Muglia, P, Barnes, MR, Whittaker, JC, Tozzi, F, Holsboer, F, Preisig, M, Farmer, AE, Breen, G, Craig, IW, McGuffin, P (2010). Genome-wide association study of major recurrent depression in the U.K. population. American Journal of Psychiatry 167, 949–957.CrossRefGoogle ScholarPubMed

López-León, S, Janssens, AC, González-Zuloeta Ladd, AM, Del-Favero, J, Claes, SJ, Oostra, BA, van Duijn, CM (2008). Meta-analyses of genetic studies on major depressive disorder. Molecular Psychiatry 13, 772–785.CrossRefGoogle ScholarPubMed

Lotrich, FE, Pollock, BG (2004). Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatric Genetics 14, 121–129.CrossRefGoogle ScholarPubMed

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium (2012). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry. Published online 3 April 2012. doi:10.1038/mp.2012.21.Google Scholar

Manki, H, Kanba, S, Muramatsu, T, Higuchi, S, Suzuki, E, Matsushita, S, Ono, Y, Chiba, H, Shintani, F, Nakamura, M, Yagi, G, Asai, M (1996). Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders. Journal of Affective Disorders 40, 7–13.CrossRefGoogle ScholarPubMed

Martin, J, Cleak, J, Willis-Owen, SA, Flint, J, Shifman, S (2007). Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Molecular Psychiatry 12, 421–422.CrossRefGoogle ScholarPubMed

Maura, G, Thellung, S, Andrioli, GC, Ruelle, A, Raiteri, M (1993). Release-regulating serotonin 5-HT1D autoreceptors in human cerebral cortex. Journal of Neurochemistry 60, 1179–1182.CrossRefGoogle ScholarPubMed

McGuffin, P, Cohen, S, Knight, J (2007). Homing in on depression genes. American Journal of Psychiatry 164, 195–197.CrossRefGoogle Scholar

McGuffin, P, Katz, R, Watkins, S, Rutherford, J (1996). A hospital-based twin register of the heritability of DSM-IV unipolar depression. Archives of General Psychiatry 53, 129–136.CrossRefGoogle ScholarPubMed

McGuffin, P, Knight, J, Breen, G, Brewster, S, Boyd, PR, Craddock, N, Gill, M, Korszun, A, Maier, W, Middleton, L, Mors, O, Owen, MJ, Perry, J, Preisig, M, Reich, T, Rice, J, Rietschel, M, Jones, L, Sham, P, Farmer, AE (2005). Whole genome linkage scan of recurrent depressive disorder from the depression network study. Human Molecular Genetics 14, 3337–3345.CrossRefGoogle ScholarPubMed

McGuffin, P, Rijsdijk, F, Andrew, M, Sham, P, Katz, R, Cardno, A (2003). The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Archives of General Psychiatry 60, 497–502.CrossRefGoogle ScholarPubMed

McQuillin, A, Bass, N, Anjorin, A, Lawrence, J, Kandaswamy, R, Lydall, G, Moran, J, Sklar, P, Purcell, S, Gurling, H (2011). Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sample. European Journal of Human Genetics 19, 588–592.CrossRefGoogle ScholarPubMed

Melmer, G, Sherrington, R, Mankoo, B, Kalsi, G, Curtis, D, Gurling, HM (1991). A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to DNA loci D5S6, D5S39, and D5S76. Genomics 11, 767–769.CrossRefGoogle ScholarPubMed

Minov, C, Baghai, TC, Schule, C, Zwanzger, P, Schwarz, MJ, Zill, P, Rupprecht, R, Bondy, B (2001). Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression. Neuroscience Letters 303, 119–122.CrossRefGoogle ScholarPubMed

Miyake, A, Mochizuki, S, Takemoto, Y, Akuzawa, S (1995). Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. Molecular Pharmacology 48, 407–416.Google ScholarPubMed

Modell, S, Lauer, CJ, Schreiber, W, Huber, J, Krieg, JC, Holsboer, F (1998). Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology 18, 253–262.CrossRefGoogle ScholarPubMed

Mueller, JC, Lohmussaar, E, Magi, R, Remm, M, Bettecken, T, Lichtner, P, Biskup, S, Illig, T, Pfeufer, A, Luedemann, J, Schreiber, S, Pramstaller, P, Pichler, I, Romeo, G, Gaddi, A, Testa, A, Wichmann, HE, Metspalu, A, Meitinger, T (2005). Linkage disequilibrium patterns and tagSNP transferability among European populations. American Journal of Human Genetics 76, 387–398.CrossRefGoogle ScholarPubMed

Muglia, P, Tozzi, F, Galwey, NW, Francks, C, Upmanyu, R, Kong, XQ, Antoniades, A, Domenici, E, Perry, J, Rothen, S, Vandeleur, CL, Mooser, V, Waeber, G, Vollenweider, P, Preisig, M, Lucae, S, Muller-Myhsok, B, Holsboer, F, Middleton, LT, Roses, AD (2010). Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Molecular Psychiatry 15, 589–601.CrossRefGoogle ScholarPubMed

Munafò, MR, Durrant, C, Lewis, G, Flint, J (2009). Gene × environment interactions at the serotonin transporter locus. Biological Psychiatry 65, 211–219.CrossRefGoogle ScholarPubMed

Murray, CJ, Lopez, AD (1997). Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 349, 1436–1442.CrossRefGoogle ScholarPubMed

Nakamura, M, Ueno, S, Sano, A, Tanabe, H (2000). The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Molecular Psychiatry 5, 32–38.CrossRefGoogle ScholarPubMed

Nash, MW, Huezo-Diaz, P, Williamson, RJ, Sterne, A, Purcell, S, Hoda, F, Cherny, SS, Abecasis, GR, Prince, M, Gray, JA, Ball, D, Asherson, P, Mann, A, Goldberg, D, McGuffin, P, Farmer, A, Plomin, R, Craig, IW, Sham, PC (2004). Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. Human Molecular Genetics 13, 2173–2182.CrossRefGoogle ScholarPubMed

Nurnberger, JI Jr., Foroud, T, Flury, L, Su, J, Meyer, ET, Hu, K, Crowe, R, Edenberg, H, Goate, A, Bierut, L, Reich, T, Schuckit, M, Reich, W (2001). Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. American Journal of Psychiatry 158, 718–724.CrossRefGoogle ScholarPubMed

Ogilvie, AD, Battersby, S, Bubb, VJ, Fink, G, Harmar, AJ, Goodwim, GM, Smith, CA (1996). Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347, 731–733.CrossRefGoogle ScholarPubMed

Ohara, K, Nagai, M, Tani, K, Tsukamoto, T, Suzuki, Y (1998). Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. NeuroReport 9, 1291–1294.CrossRefGoogle ScholarPubMed

Ordway, GA, Schenk, J, Stockmeier, CA, May, W, Klimek, V (2003). Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression. Biological Psychiatry 53, 315–323.CrossRefGoogle ScholarPubMed

Oruc, L, Verheyen, GR, Furac, I, Ivezić, S, Jakovljević, M, Raeymaekers, P, Van Broeckhoven, C (1997). Positive association between the GABRA5 gene and unipolar recurrent major depression. Neuropsychobiology 36, 62–64.CrossRefGoogle ScholarPubMed

Owen, D, Du, L, Bakish, D, Lapierre, YD, Hrdina, PD (1999). Norepinephrine transporter gene polymorphism is not associated with susceptibility to major depression. Psychiatry Research 87, 1–5.CrossRefGoogle Scholar

Ozelius, L, Hsu, YP, Bruns, G, Powell, JF, Chen, S, Weyler, W, Utterback, M, Zucker, D, Haines, J, Trofatter, JA (1988). Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism. Genomics 3, 53–58.CrossRefGoogle ScholarPubMed

Panagiotou, OA, Ioannidis, JP; Genome-Wide Significant Project (2012). What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. International Journal of Epidemiology 41, 273–286.CrossRefGoogle ScholarPubMed

Pergadia, ML, Glowinski, AL, Wray, NR, Agrawal, A, Saccone, SF, Loukola, A, Broms, U, Korhonen, T, Penninx, BWJH, Grant, JD, Nelson, EC, Henders, AK, Schrage, AJ, Chou, Y, Keskitalo-Vuokko, K, Zhu, Q, Gordon, SD, Vink, JM, de Geus, EJC, MacGregor, S, Liu, JZ, Willemsen, G, Medland, SE, Boomsma, DI, Montgomery, GW, Rice, JP, Goate, AM, Heath, AC, Kaprio, J, Martin, NG, Madden, PAF (2011). A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. American Journal of Psychiatry 168, 848–852.CrossRefGoogle ScholarPubMed

Plotsky, PM, Owens, MJ, Nemeroff, CB (1998). Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis. Psychiatric Clinics of North America 21, 293–307.CrossRefGoogle ScholarPubMed

Porzgen, P, Bonisch, H, Bruss, M (1995). Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochemical and Biophysical Research Communications 215, 1145–1150.CrossRefGoogle ScholarPubMed

Priestley, JV, Cuello, AC (1982). Localisation studies on the interactions between neuropeptides and neurotransmitters involved in depression. Advances in Biochemical Psychopharmacology 31, 157–169.Google ScholarPubMed

Puig-Antich, J, Goetz, D, Davies, M, Kaplan, T, Davies, S, Ostrow, L, Asnis, L, Twomey, J, Iyengar, S, Ryan, ND (1989). A controlled family history study of prepubertal major depressive disorder. Archives of General Psychiatry 46, 406–418.CrossRefGoogle ScholarPubMed

Quested, DJ, Whale, R, Sharpley, AL, McGavin, CL, Crossland, N, Harrison, PJ, Cowen, PJ (1999). Allelic variation in the 5-HT2C receptor (HTR2C) and functional responses to the 5-HT2C receptor agonist, m-chlorophenylpiperazine. Psychopharmacology (Berlin) 144, 306–307.CrossRefGoogle Scholar

Rietschel, M, Mattheisen, M, Frank, J, Treutlein, J, Degenhardt, F, Breuer, R, Steffens, M, Mier, D, Esslinger, C, Walter, H, Kirsch, P, Erk, S, Schnell, K, Herms, S, Wichmann, HE, Schreiber, S, Jöckel, KH, Strohmaier, J, Roeske, D, Haenisch, B, Gross, M, Hoefels, S, Lucae, S, Binder, EB, Wienker, TF, Schulze, TG, Schmäl, C, Zimmer, A, Juraeva, D, Brors, B, Bettecken, T, Meyer-Lindenberg, A, Müller-Myhsok, B, Maier, W, Nöthen, MM, Cichon, S (2010). Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression. Biological Psychiatry 66, 578–585.CrossRefGoogle Scholar

Risch, N, Herrell, R, Lehner, T, Liang, KY, Eaves, L, Hoh, J, Griem, A, Kovacs, M, Ott, J, Merikangas, KR (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. Journal of the American Medical Association 301, 2462–2471.CrossRefGoogle ScholarPubMed

Rivera, M, Gutierrez, B, Molina, E, Torres-Gonzalez, F, Bellon, JA, Moreno-Kustner, B, King, M, Nazareth, I, Martinez-Gonzalez, LJ, Martinez-Espin, E, Munoz-Garcia, MM, Motrico, E, Martinez-Canavate, T, Lorente, JA, Luna, JD, Cervilla, JA (2009). High-activity variants of the uMAOA polymorphism increase the risk for depression in a large primary care sample. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 150B, 395–402.CrossRefGoogle Scholar

Rucker, JJ, Breen, G, Pinto, D, Pedroso, I, Lewis, CM, Cohen-Woods, S, Uher, R, Schosser, A, Rivera, M, Aitchison, KJ, Craddock, N, Owen, MJ, Jones, L, Jones, I, Korszun, A, Muglia, P, Barnes, MR, Preisig, M, Mors, O, Gill, M, Maier, W, Rice, J, Rietschel, M, Holsboer, F, Farmer, AE, Craig, IW, Scherer, SW, McGuffin, P (2011). Genome-wide association analysis of copy number variation in recurrent depressive disorder. Molecular Psychiatry. Published online: 1 November 2011. doi:10.1038/mp2011.144.Google ScholarPubMed

Ryu, SH, Lee, SH, Lee, HJ, Cha, JH, Ham, BJ, Han, CS, Choi, MJ, Lee, MS (2004). Association between norepinephrine transporter gene polymorphism and major depression. Neuropsychobiology 49, 174–177.CrossRefGoogle ScholarPubMed

Sapolsky, RM, Uno, H, Rebert, CS, Finch, CE (1990). Hippocampal damage associated with prolonged glucocorticoid exposure in primates. Journal of Neuroscience 10, 2897–2902.CrossRefGoogle ScholarPubMed

Sasaki, T, Hattori, M, Sakai, T, Kato, T, Kunugi, H, Hirose, T, Nanko, S (1998). The monoamine oxidase-A gene and major psychosis in Japanese subjects. Biological Psychiatry 44, 922–924.CrossRefGoogle ScholarPubMed

Schulze, TG, Muller, DJ, Krauss, H, Scherk, H, Ohlraun, S, Syagailo, YV, Windemuth, C, Neidt, H, Grassle, M, Papassotiropoulos, A, Heun, R, Nothen, MM, Maier, W, Lesch, KP, Rietschel, M (2000). Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. American Journal of Medical Genetics 96, 801–803.3.0.CO;2-4>CrossRefGoogle ScholarPubMed

Schumacher, J, Jamra, RA, Becker, T, Ohlraun, S, Klopp, N, Binder, EB, Schulze, TG, Deschner, M, Schmal, C, Hofels, S, Zobel, A, Illig, T, Propping, P, Holsboer, F, Rietschel, M, Nothen, MM, Cichon, S (2005). Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biological Psychiatry 58, 307–314.CrossRefGoogle ScholarPubMed

Shi, J, Potash, JB, Knowles, JA, Weissman, MM, Coryell, W, Scheftner, WA, Lawson, WB, DePaulo, Jr. JR, Gejman, PV, Sanders, AR, Johnson, JK, Adams, P, Chaudhury, S, Jancic, D, Evgrafov, O, Zvinyatskovskiy, A, Ertman, N, Gladis, M, Neimanas, K, Goodell, M, Hale, N, Ney, N, Verma, R, Mirel, D, Holmans, P, Levinson, DF (2011). Genome-wide association study of recurrent early-onset major depressive disorder. Molecular Psychiatry 16, 193–201.CrossRefGoogle ScholarPubMed

Shyn, SI, Shi, J, Kraft, JB, Potash, JB, Knowles, JA, Weissman, MM, Garriock, HA, Yokoyama, JS, McGrath, PJ, Peters, EJ, Scheftner, WA, Coryell, W, Lawson, WB, Jancic, D, Gejman, PV, Sanders, AR, Holmans, P, Slager, SL, Levinson, DF, Hamilton, SP (2011). Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Molecular Psychiatry 16, 202–215.CrossRefGoogle ScholarPubMed

Smith, MA, Makino, S, Kvetnansky, R, Post, RM (1995). Effects of stress on neurotrophic factor expression in the rat brain. Annals of the New York Academy of Sciences 771, 234–239.CrossRefGoogle ScholarPubMed

Sullivan, PF, de Geus, EJ, Willemsen, G, James, MR, Smit, JH, Zandbelt, T, Arolt, V, Baune, BT, Blackwood, D, Cichon, S, Coventry, WL, Domschke, K, Farmer, A, Fava, M, Gordon, SD, He, Q, Heath, AC, Heutink, P, Holsboer, F, Hoogendijk, WJ, Hottenga, JJ, Hu, Y, Kohli, M, Lin, D, Lucae, S, Macintyre, DJ, Maier, W, McGhee, KA, McGuffin, P, Montgomery, GW, Muir, WJ, Nolen, WA, Nothen, MM, Perlis, RH, Pirlo, K, Posthuma, D, Rietschel, M, Rizzu, P, Schosser, A, Smit, AB, Smoller, JW, Tzeng, JY, van Dyck, R, Verhage, M, Zitman, FG, Martin, NG, Wray, NR, Boomsma, DI, Penninx, BW (2009). Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular Psychiatry 14, 359–375.CrossRefGoogle ScholarPubMed

Sullivan, PF, Neale, MC, Kendler, KS (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry 157, 1552–1562.CrossRefGoogle ScholarPubMed

Syagailo, YV, Stober, G, Grassle, M, Reimer, E, Knapp, M, Jungkunz, G, Okladnova, O, Meyer, J, Lesch, KP (2001). Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders. American Journal of Medical Genetics 105, 168–171.CrossRefGoogle ScholarPubMed

Tadic, A, Rujescu, D, Szegedi, A, Giegling, I, Singer, P, Moller, HJ, Dahmen, N (2003). Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 117, 1–6.CrossRefGoogle Scholar

Tan, EC, Chan, AO, Tan, CH, Mahendran, R, Wang, A, Chua, HC (2003). Case-control and linkage disequilibrium studies of the tryptophan hydroxylase gene polymorphisms and major depressive disorder. Psychiatric Genetics 13, 151–154.CrossRefGoogle ScholarPubMed

Terracciano, A, Tanaka, T, Sutin, AR, Sanna, S, Deiana, B, Lai, S, Uda, M, Schlessinger, D, Abecasis, GR, Ferrucci, L, Costa, PT Jr. (2010). Genome-wide association scan of trait depression. Biological Psychiatry 68, 811–817.CrossRefGoogle ScholarPubMed

Thapar, A, McGuffin, P (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry 165, 259–265.CrossRefGoogle ScholarPubMed

Thomson, W, Barton, A, Ke, X, Eyre, S, Hinks, A, Bowes, J, Donn, R, Symmons, D, Hider, S, Bruce, IN, Wilson, AG, Marinou, I, Morgan, A, Emery, P, Carter, A, Steer, S, Hocking, L, Reid, DM, Wordsworth, P, Harrison, P, Strachan, D, Worthington, J (2007). Rheumatoid arthritis association at 6q23. Nature Genetics 39, 1431–1433.CrossRefGoogle ScholarPubMed

Tsai, SJ, Hong, CJ, Wang, YC (1999). Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors. NeuroReport 10, 3773–3775.CrossRefGoogle ScholarPubMed

Uher, R (2011). Genes, environment, and individual differences in responding to treatment for depression. Harvard Review of Psychiatry 19, 109–124.CrossRefGoogle ScholarPubMed

Verhagen, M, van der Meij, A, van Deurzen, PA, Janzing, JG, Arias-Vasquez, A, Buitelaar, JK, Franke, B (2010). Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Molecular Psychiatry 15, 260–271.CrossRefGoogle ScholarPubMed

Verma, R, Holmans, P, Knowles, JA, Grover, D, Evgrafov, OV, Crowe, RR, Scheftner, WA, Weissman, MM, DePaulo, Jr. JR, Potash, JB, Levinson, DF (2008). Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. Biological Psychiatry 63, 1185–1189.CrossRefGoogle ScholarPubMed

Viikki, M, Kampman, O, Illi, A, Setala-Soikkeli, E, Anttila, S, Huuhka, M, Nuolivirta, T, Poutanen, O, Mononen, N, Lehtimaki, T, Leinonen, E (2010). TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response. Neuroscience Letters 468, 80–84.CrossRefGoogle ScholarPubMed

Walsh, T, McClellan, JM, McCarthy, SE, Addington, AM, Pierce, SB, Cooper, GM, Nord, AS, Kusenda, M, Malhotra, D, Bhandari, A, Stray, SM, Rippey, CF, Roccanova, P, Makarov, V, Lakshmi, B, Findling, RL, Sikich, L, Stromberg, T, Merriman, B, Gogtay, N, Butler, P, Eckstrand, K, Noory, L, Gochman, P, Long, R, Chen, Z, Davis, S, Baker, C, Eichler, EE, Meltzer, PS, Nelson, SF, Singleton, AB, Lee, MK, Rapoport, JL, King, MC, Sebat, J (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320, 539–543.CrossRefGoogle ScholarPubMed

Walther, DJ, Bader, M (2003). A unique central tryptophan hydroxylase isoform. Biochemical Pharmacology 66, 1673–1680.CrossRefGoogle ScholarPubMed

Wang, HC, Yeh, TL, Chang, HH, Gean, PW, Chi, MH, Yang, YK, Lu, RB, Chen, PS (2011). TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients. Psychopharmacology (Berlin) 213, 773–779.CrossRefGoogle Scholar

Weissman, MM, Fendrich, M, Warner, V, Wickramaratne, P (1992). Incidence of psychiatric disorder in offspring at high and low risk for depression. Journal of the American Academy of Child and Adolescent Psychiatry 31, 640–648.CrossRefGoogle ScholarPubMed

Weissman, MM, Gammon, GD, John, K, Merikangas, KR, Warner, V, Prusoff, BA, Sholomskas, D (1987). Children of depressed parents. Increased psychopathology and early onset of major depression. Archives of General Psychiatry 44, 847–853.CrossRefGoogle ScholarPubMed

Wendland, JR, Martin, BJ, Kruse, MR, Lesch, KP, Murphy, DL (2006). Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry 11, 224–226.CrossRefGoogle ScholarPubMed

Wilhelm, K, Mitchell, PB, Niven, H, Finch, A, Wedgwood, L, Scimone, A, Blair, IP, Parker, G, Schofield, PR (2006). Life events, first depression onset and the serotonin transporter gene. British Journal of Psychiatry 188, 210–215.CrossRefGoogle ScholarPubMed

Willis-Owen, SA, Turri, MG, Munafo, MR, Surtees, PG, Wainwright, NW, Brixey, RD, Flint, J (2005). The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biological Psychiatry 58, 451–456.CrossRefGoogle ScholarPubMed

Wray, NR, Pergadia, ML, Blackwood, DH, Penninx, BW, Gordon, SD, Nyholt, DR, Ripke, S, MacIntyre, DJ, McGhee, KA, Maclean, AW, Smit, JH, Hottenga, JJ, Willemsen, G, Middeldorp, CM, de Geus, EJ, Lewis, CM, McGuffin, P, Hickie, IB, van den Oord, EJ, Liu, JZ, Macgregor, S, McEvoy, BP, Byrne, EM, Medland, SE, Statham, DJ, Henders, AK, Heath, AC, Montgomery, GW, Martin, NG, Boomsma, DI, Madden, PA, Sullivan, PF (2012). Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Molecular Psychiatry 17, 36–48.CrossRefGoogle ScholarPubMed

Yamada, K, Hattori, E, Iwayama, Y, Ohnishi, T, Ohba, H, Toyota, T, Takao, H, Minabe, Y, Nakatani, N, Higuchi, T, Detera-Wadleigh, SD, Yoshikawa, T (2006). Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biological Psychiatry 60, 192–201.CrossRefGoogle ScholarPubMed

Youdim, MB, Edmondson, D, Tipton, KF (2006). The therapeutic potential of monoamine oxidase inhibitors. Nature Reviews Neuroscience 7, 295–309.CrossRefGoogle ScholarPubMed

Yu, YW, Chen, TJ, Wang, YC, Liou, YJ, Hong, CJ, Tsai, SJ (2003). Association analysis for neuronal nitric oxide synthase gene polymorphism with major depression and fluoxetine response. Neuropsychobiology 47, 137–140.CrossRefGoogle ScholarPubMed

Zeggini, E, Weedon, MN, Lindgren, CM, Frayling, TM, Elliott, KS, Lango, H, Timpson, NJ, Perry, JR, Rayner, NW, Freathy, RM, Barrett, JC, Shields, B, Morris, AP, Ellard, S, Groves, CJ, Harries, LW, Marchini, JL, Owen, KR, Knight, B, Cardon, LR, Walker, M, Hitman, GA, Morris, AD, Doney, AS, McCarthy, MI, Hattersley, AT (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336–1341.CrossRefGoogle ScholarPubMed

Zhang, D, Cheng, L, Qian, Y, Alliey-Rodriguez, N, Kelsoe, JR, Greenwood, T, Nievergelt, C, Barrett, TB, McKinney, R, Schork, N, Smith, EN, Bloss, C, Nurnberger, J, Edenberg, HJ, Foroud, T, Sheftner, W, Lawson, WB, Nwulia, EA, Hipolito, M, Coyell, W, Rice, J, Byerley, W, McMahon, F, Schulze, TG, Berrettini, W, Potash, JB, Belmonte, PL, Zandi, PP, McInnes, MG, Zöllner, S, Craig, D, Szelinger, S, Koller, D, Christian, SL, Liu, C, Gershon, ES (2009). Singleton deletions throughout the genome increase risk of bipolar disorder. Molecular Psychiatry 14, 376–380.CrossRefGoogle ScholarPubMed

Zhang, J, Chen, Y, Zhang, K, Yang, H, Sun, Y, Fang, Y, Shen, Y, Xu, Q (2010). A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder. Biological Psychiatry 68, 795–800.CrossRefGoogle ScholarPubMed

Zhang, X, Gainetdinov, RR, Beaulieu, JM, Sotnikova, TD, Burch, LH, Williams, RB, Schwartz, DA, Krishnan, KR, Caron, MG (2005). Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11–16.CrossRefGoogle ScholarPubMed

Zill, P, Baghai, TC, Engel, R, Zwanzger, P, Schule, C, Minov, C, Behrens, S, Bottlender, R, Jager, M, Rupprecht, R, Moller, HJ, Ackenheil, M, Bondy, B (2003). Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 120, 85–89.CrossRefGoogle Scholar

Zubenko, GS, Hughes, HB 3rd, Maher, BS, Stiffler, JS, Zubenko, WN, Marazita, ML (2002). Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. American Journal of Medical Genetics 114, 980–987.CrossRefGoogle ScholarPubMed

Zubenko, GS, Maher, B, Hughes, HB 3rd, Zubenko, WN, Stiffler, JS, Kaplan, BB, Marazita, ML (2003). Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 123, 1–18.CrossRefGoogle Scholar