Estimation of microsatellite mutation rates in Drosophila melanogaster | Genetics Research | Cambridge Core (original) (raw)

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Published online by Cambridge University Press: 18 January 2001

JOSÉ FERNANDO VÁZQUEZ

Affiliation:

Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain

TRINIDAD PÉREZ

Affiliation:

Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain

JESÚS ALBORNOZ

Affiliation:

Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain

ANA DOMÍNGUEZ

Affiliation:

Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain

Article contents

Abstract

Abstract

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Microsatellite mutations were studied in a set of 175 mutation accumulation lines, all of them independently derived from a completely homozygous population of Drosophila melanogaster and maintained under strong inbreeding during 80 generations. We assayed 28 microsatellites and detected two mutations. One mutation consisted of a single addition of a dinucleotide repeat and the other was a deletion of five trinucleotide repeats. The average mutation rate was 5·1 × 10−6, in full agreement with previous estimates from two different sets of mutation accumulation lines.

Type

SHORT PAPER