Determination of the colonization resistance of the digestive tract of individual mice | Epidemiology & Infection | Cambridge Core (original) (raw)

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It has been shown that it is possible to investigate the colonization resistance in individual mice by determining the concentration of a certain contaminant (S.R.-E. coli) in the faeces during the first 4 days after contamination. Experimental contamination is contra-indicated in many cases such as in individuals with decreased resistance to infection. Particularly in this group, the value of the colonization resistance should be determined. It appeared to be possible to determine the colonization resistance in such individuals by quantitative biotyping of the Enterobacteriaceae species in the faeces on several consecutive days.

References

Abrams, G. D. & Bishop, J. E. (1966). Effect of the normal microbial flora on the resistance of the small intestines to infection. Journal of Bacteriology 92, 1604.Google Scholar

Bazin, H., Maldague, P. & Heremans, J. F. (1970). The metabolism of different immunoglobulin classes in irradiated mice. Immunology 18, 361.Google Scholar

Bazin, H., Maldague, P., Schonne, E., Grabbé, P. A., Bauldon, H. & Heremans, J. F. (1971). The metabolism of different immunoglobulin classes in irradiated mice. Immunology 20, 571.Google Scholar

Dankert, J., (1973). Biotyping of Enterobacteriaceae: A method to determine the efficacy of the barrier function of isolation units. Germfree Research, Biological Effect of Onotobiotic Environments p. 59. New York: Academic Press.Google Scholar

Freter, R. (1972). Parameters affecting the association of Vibrios with intestinal surface in experimental cholera. Infection and Immunity 6, 134.Google Scholar

Gordon, L. E., Ruml, D., Hahne, H. J. & Miller, C. P. (1955). Studies on susceptibility to infection following ionizing radiation. Journal of Experimental Medicine 102, 413.Google Scholar

van der Waaij, D. (1969). Similarities between germfree mice and mice with an antibiotic decontaminated digestive tract. In: Germfree Biology p. 181. New York: Plenum Press.Google Scholar

van der Waaij, D. & Andreas, A. H. (1971). Prevention of airborne contamination and cross-contamination in germ-free mice by laminar flow. Journal of Hygiene 69, 83.Google Scholar

van der Waaij, D., Berghuis-de Vries, J. M. & Lekkerkerk-van der Wees, J. E. C. (1971). Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. Journal of Hygiene 69, 405.Google Scholar

van der Waaij, D., de Vries, J. M. & Lekkerkerk, J. E. C. (1972). Colonization resistance of the digestive tract and the occurrence of spread of bacteria to lymphatic organs in mice. Journal of Hygiene 70, 55.Google Scholar

van der Waaij, D., Speltte, T. M. & Vossen, J. M. (1972). Biotyping of Enterobacteriaceae as a test for the evaluation of isolation systems. Journal of Hygiene 70, 639.Google Scholar

Williams, R. C. & Gibbons, R. J. (1972). Inhibition of bacterial adherence by secretory immunoglobulin A: A mechanism of antigen disposal. Science, New York 177, 697.Google Scholar