Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica | Parasitology | Cambridge Core (original) (raw)
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Published online by Cambridge University Press: 01 July 1997
G. P. CURLEY
Affiliation:
School of Biological Sciences, Dublin City University, Dublin 9, Ireland
J. P. DALTON
Affiliation:
School of Biological Sciences, Dublin City University, Dublin 9, Ireland
Abstract
A cDNA was isolated from a cDNA expression library using serum prepared against a high molecular mass fraction of Fasciola hepatica excretory–secretory products. The full-length cDNA encodes a member of the recently described peroxiredoxin antioxidant family. Peroxiredoxin could be the major hydrogen peroxide removing antioxidant in F. hepatica since this parasite does not express a catalase and expresses little glutathione peroxidase activity. This novel antioxidant may be involved in functions such as protection against reactive oxygen species (ROS) generated by metabolic processes and/or protection of the parasite against ROS released by immune effector cells.
Keywords
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Type
Research Article
Copyright
1997 Cambridge University Press
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