Antimicrobial resistance among urinary tract infection (UTI) isolates in Europe: results from the SENTRY Antimicrobial Surveillance Program 1997 (original) (raw)

Abstract

The SENTRY Antimicrobial Surveillance Program was established to monitor the occurrence and antimicrobial susceptibility of bacterial pathogens via an international network of sentinel hospitals. Twenty European hospitals referred a total of 887 urinary tract infection (UTI) isolates to the European SENTRY reference laboratory during the period October–December 1997. Ninety percent of the referred species were represented by Escherichia coli (52%), Enterococcus spp. (12%), Klebsiella spp. (7%), Proteus spp. (7%), Pseudomonas aeruginosa (7%), and Enterobacter spp. (5%). The susceptibility of E. coli isolates to penicillins was less than 60%, while almost all of the isolates were susceptible to piperacillin/tazobactam (98% susceptibility), cephalosporins (98%), and carbapenems (100%). Amikacin was the best aminoglycoside (99.8% susceptibility). The susceptibility to quinolones was only 88–89%, with highest levels of resistance observed for isolates from Portugal, Italy, England, The Netherlands, and some centers in France, Spain, and Poland. The susceptibility of Klebsiella spp. to the newer generations of cephalosporins was 82–95% and to the carbapenems 100%. Amikacin was again the best aminoglycoside (94% susceptibility). The susceptibility of Enterobacter spp. to any ß-lactam antibiotic was poor, except for the carbapenems (100% susceptibility) and cefepime (90% susceptibility), while the susceptibility to aminoglycosides was 80–89%. Proteus spp. showed complete susceptibility to cefepime, ceftriaxone, the carbapenems, and piperacillin/tazobactam, while the susceptibility of P. aeruginosa isolates was poor, with best results for the carbapenems (susceptibility 89%), piperacillin/tazobactam (susceptibility 84%), and amikacin and ticarcillin (susceptibility to both 80%). Enterococcus spp. showed the highest susceptibility to vancomycin (98%), teicoplanin (98%), and ampicillin (94%).

Access this article

Log in via an institution

Subscribe and save

• Starting from 10 chapters or articles per month
• Access and download chapters and articles from more than 300k books and 2,500 journals
• Cancel anytime View plans

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

• Ayliffe GAJ (1997) The progressive intercontinental spread of methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. 24 (Suppl. 1): S74-S79.
  Google Scholar
• Baquero F (1996) Trends in antibiotic resistance of respiratory pathogens: an analysis and commentary on a collaborative surveillance study. J. Antimicrob. Chemother. 38 (Suppl. A): 117–132.
  Google Scholar
• Cohen ML (1992) Epidemiology of drug resistance; implications for a post antimicrobial era. Science 257: 1050–1055.
  Google Scholar
• Cornaglia G, Ligozzi M, Mazzariol A, Valentini M, Orefici G & Fontana R (1996) Rapid increase of resistance to erythromycin and clindamycin in Streptococcus pyogenes in Italy, 1993–1995. Emerg. Infect. Dis. 2: 339–342.
  Google Scholar
• Gold SG & Moellering RC (1996) Antimicrobial drug resistance. New Engl. J. Med. 335: 1445–1453.
  Google Scholar
• Grüneberg RN (1994) Changes in urinary pathogens and their antibiotic sensitivities, 1971–1992. J. Antimicrob. Chemother. 33 (Suppl. A): 1–8.
  Google Scholar
• Johnson JR & Stamm WE. (1989) Urinary tract infections in women: diagnosis and treatment. Ann. Intern. Med. 111: 906–917.
  Google Scholar
• Jones RN (1996) Impact of changing pathogens and antimicrobial susceptibility patterns in the treatment of serious infections in hospitalized patients. Am. J. Med. 100 (Suppl. 6A): 3S-12S.
  Google Scholar
• Leqclerc R (1997) Enterococci acquire new kinds of resistance. Clin. Infect. Dis. 24 (Suppl. 1): S80-S84.
  Google Scholar
• Marco CA & Parker K (1997) Antimicrobial resistance among organisms causing urinary tract infections. Acad. Emerg. Med. 4:159–160.
  Google Scholar
• Morrison AM & Wenzel RP (1986) Nosocomial urinary tract infections due to Enterococcus. Arch. Intern. Med. 146: 1549–1551.
  Google Scholar
• Naber KG, Witte W, Bauernfeind A, Wiedemann B. Wagenlehener F, Klare I & Heisig P (1994) Clinical significance and spread of fluoroquinilone resistant uropathogens in hospitalised urological patients. Infection 22 (Suppl. 2): S122-S127.
  Google Scholar
• National Committee for Clinical Laboratory Standards (1998) Performance standards for antimicrobial susceptibility testing. Supplement tables, M100-S8. Wayne, PA: NCCLS.
  Google Scholar
• O'Brien TF & Stelling JM (1996) WHONET: removing obstacles to the full use of information about antimicrobial resistance. Diagn. Microbiol. Infect. Dis. 25: 162–168.
  Google Scholar
• Rahal K, Wang F, Schindler J, Rowe B, Cookson B, Huovinen P, Marton A, Lalitha MK, Semina N, Kronvall G & Guzman M (1997) Reports on surveillance of antimicrobial remittance in individual countries. Clin. Infect. Dis. 24 (Suppl. 1): S169-S175.
  Google Scholar
• Spika JS, Facklam RR, Plikaytis BD, Oxtoby MJ & the Pneumococcal Surveillance Working Group (1991) Antimicrobial resistance of Streptococcus pneumoniae in the United States, 1979–1987. J. Infect. Dis. 163: 1273–1278.
  Google Scholar
• Struelens MJ & Mertens MR (1994) National survey of methicillinresistant Staphylococcus aureus in Belgian hospitals: detection methods, prevalence trends and infection control measures. Eur. J. Clin. Microbiol. Infect. Dis. 13: 56–63.
  Google Scholar
• Warren JW (1997) Catheter-associated urinary tract infections. Infect. Dis. Clin. N. Am. 11: 609–622.
  Google Scholar

Download references

Author information

Authors and Affiliations

1. Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Hospital Utrecht, room G04.614, PO Box 85500, 3508, GA Utrecht, The Netherlands
   Ad C. Fluit
2. Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Hospital Utrecht, room G04.614, PO Box 85500, 3508, GA Utrecht, The Netherlands
   Mark E. Jones, Franz-Josef Schmitz & Jan Verhoef
3. Department of Clinical Microbiology, Hôpital St. Joseph, Paris, France
   Jacques Acar
4. Bristol-Myers Squibb Company, Princeton, NJ, USA
   Renu Gupta

Authors

1. Ad C. Fluit
2. Mark E. Jones
3. Franz-Josef Schmitz
4. Jacques Acar
5. Renu Gupta
6. Jan Verhoef

Corresponding author

Correspondence toAd C. Fluit.

Rights and permissions

About this article

Cite this article

Fluit, A.C., Jones, M.E., Schmitz, FJ. et al. Antimicrobial resistance among urinary tract infection (UTI) isolates in Europe: results from the SENTRY Antimicrobial Surveillance Program 1997.Antonie Van Leeuwenhoek 77, 147–152 (2000). https://doi.org/10.1023/A:1002003123629

Download citation

• Issue date: February 2000
• DOI: https://doi.org/10.1023/A:1002003123629