- Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992; 69: 11–25.
Google Scholar
- Springer TA. Adhesion receptors of the immune system. Nature 1990; 346: 425–34.
Google Scholar
- Dedhar S, Hannigan GE. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr Opin Cell Biol 1996; 8: 657–69.
Google Scholar
- Juliano R. Signal transduction by integrins and its role in the regulation of tumor growth. Cancer Metastasis Rev 1994; 13: 25–30.
Google Scholar
- Giancotti FG, Mainiero F. Integrin-mediated adhesion and signaling in tumorigenesis. Biochim Biophys Acta 1994; 1198: 47–64.
Google Scholar
- Chan BM, Matsuura N, Takada Y et al. In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science 1992; 251: 1600–2.
Google Scholar
- Bertomeu MC, Gallo S, Lauri D et al. Interleukin 1-induced cancer cell/endothelial cell adhesion in vitro and its relationship to metastasis in vivo: role of vessel wall 13-HODE synthesis and integrin expression. Clin Exp Metastasis 1993; 11: 243–50.
Google Scholar
- Matsuura N, Puzon-McLaughlin W, Irie A et al. Induction of experimental bone metastasis in mice by transfection of integrin alpha 4 beta 1 into tumor cells. Am J Pathol 1996; 148: 55–61.
Google Scholar
- Yamamoto H, Irie A, Fukushima Y et al. Abrogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin alpha6 subunit expression. Int J Cancer 1996; 65: 519–24.
Google Scholar
- Ruiz P, Dunon D, Sonnenberg A, Imhof BA. Suppression of mouse melanoma metastasis by EA-1, a monoclonal antibody specific for alpha(6)-integrins. Cell Adhesion Commun 1993; 1: 67–81.
Google Scholar
- Saiki I, Murata J, Iida J et al. The inhibition of murine lung metastases by synthetic polypeptides [poly(arg-gly-asp) and poly(tyr-ile-gly-serarg)] with a core sequence of cell adhesion molecules. Br J Cancer 1988; 59: 194–7.
Google Scholar
- De Melker AA, Sonnenberg A. The role of the cytoplasmic domain of _α_6 integrin in the assembly and function of _α_6_β_1 and _α_6_β_4. Eur J Biochem 1996; 241: 254–64.
Google Scholar
- Hynes RO. Targeted mutations in cell adhesion genes: what have we learned from them? Dev Biol 1996; 180: 402–12.
Google Scholar
- Zutter MM, Mazoujian G, Santoro SA. Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast. Am J Pathol 1990; 137: 863–70.
Google Scholar
- Pignatelli M, Cardillo MR, Hanby A, Stamp GWH. Integrins and their accessory adhesion molecules in mammary carcinoma. Hum Pathol 1992; 23: 1159–66.
Google Scholar
- Natali PG, Nicotra MR, Botti C et al. Changes in expression of _α_6/_β_4 integrin heterodimer in primary and metastatic breast cancer. Br J Cancer 1992; 66: 318–22.
Google Scholar
- Koukoulis GK, Virtanen I, Korhonen M, et al. Immunohistochemical localization of integrins in normal, hyperplastic and neoplastic breast. Am J Pathol 1991; 139: 787–99.
Google Scholar
- Friedrichs K, Riuz P, Franke F et al. High expression level of _α_6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res 1995; 55: 901–6.
Google Scholar
- Tagliabue E, Ghirelli C, Squicciarini P et al. Prognostic value of _α_6_β_4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clin Cancer Res 1998; 4: 407–10.
Google Scholar
- Hogervorst F, Kuikman I, Van Kessel AG, Sonnenberg A. Molecular cloning of the human _α_6 integrin subunit. Alternative splicing of the _α_6 mRNA and chromosomal localization of the _α_6 and _β_4 genes. Eur J Biochem 1991; 199: 425–33.
Google Scholar
- Hedman H, Alenius M, Lundgren E. Defective expression of beta 1-integrins in cells with constitutively active alpha L beta 2-integrins. Exp Cell Res 1997; 232: 270–6.
Google Scholar
- Tamura RN, Rozzo C, Starr L et al. Epithelial integrin _α_6_β_4: complete primary structure of _α_6 and variant forms of _β_4. J Cell Biol 1990; 111: 1593–1604.
Google Scholar
- Price JE, Polyzos A, Zhang RD, Daniels LM. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res 1996; 50: 717–21.
Google Scholar
- Price JE. Metastasis from human breast cancer cell lines. Breast Cancer Res Treat 1996; 39: 93–102
Google Scholar
- Tennenbaum T, Belanger AJ, Glick AB et al. A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis. Proc Natl Acad Sci USA 1995; 92: 7041–5.
Google Scholar
- Kemperman H, Wijnands Y, de Rijk D, Roos E. The integrin _α_6_β_4 on TA3/Ha mammary carcinoma cells is involved in adhesion to hepatocytes. Cancer Res 1993; 53: 3611–7.
Google Scholar
- Shaw LM, Chao C, Wewer UM, Mercurio AM. Function of the integrin _α_6_β_1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor. Cancer Res 1996; 56: 959–63.
Google Scholar
- Dedhar S, Saulnier R, Nagle R, Overall CM. Specific alterations in the expression of _α_3_β_1 and _α_6_β_4 integrins in highly invasive and metastatic variants of human prostatic carcinoma cells selected by in vitro invasion through reconstituted basement membrane. Clin Exp Metastasis 1993; 11: 391–400.
Google Scholar
- Price JE, Fabra A, Zhang RD et al. Characterization of variants of a human breast cancer cell line isolated from metastases in different organs of nude mice. Int J Oncology 1994; 5: 459–67.
Google Scholar
- Wewer UM, Shaw LM, Albrechtsen R, Mercurio AM. The integrin _α_6_β_1 promotes the survival of metastatic human breast carcinoma cells in mice. Am J Pathol 1997; 151: 1191–8.
Google Scholar
- Mainiero F, Pepe A, Wary KH et al. Signal transduction by the _α_6_β_4 integrin: distinct _β_4 subunit sites mediate recruitment of Shc/Grb2 and association with cytoskeleton of hemidesmosomes. EMBO J 14: 4470- 81.
- Spinardi L, Ren YL, Sanders R, Giancotti FG. The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell 1993; 4: 871–84.
Google Scholar
- Pyke C, Salo S, Ralfkiaer E et al. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res 1995; 55: 4132–9.
Google Scholar
- Shaw LM, Rabinovitz I, Wang HHF et al. Activation of phosphoinositide 3-OH kinase by the _α_6_β_4 integrin promotes carcinoma invasion. Cell 1997; 91: 949–60.
Google Scholar
- Clarke AS, Lotz MM, Chao C, Mercurio AM. Activation of the p21 pathway of growth arrest and apoptosis by the beta(4) integrin cytoplasmic domain. J Biol Chem 1995; 270: 22673–6.
Google Scholar
- Kim SY, Bachman NJ, Nair TS et al. Beta 4 integrin transfection of UM-UC-2 (human bladder carcinoma) cells: stable expression of a spontaneous cytoplasmic truncation mutant with rapid loss of clones expressing intact beta 4. Cancer Res 1997; 57: 38–42.
Google Scholar
- Clarke AS, Lotz MM, Mercurio AM. A novel structural variant of the human beta 4 integrin cDNA. Cell Adhesion Commun. 1994; 2: 1–6.
Google Scholar
- Strunck E, Vollmer G. Variants of integrin _β_4 subunit in human endometrial adenocarcinoma cells: mediators of ECM-induced differentiation? Biochem Cell Biol 1996; 74: 867–73.
Google Scholar
- van Valen F, Hanenberg H, Jurgens H. Expression of functional very late antigen-alpha 1,-alpha 2,-alpha 3 and-alpha 6 integrins on Ewing's sarcoma and primitive peripheral neuroectodermal tumour cells and modulation by interferon-gamma and tumour necrosis factor-alpha. Eur J Cancer 1994; 30A: 2119–25.
Google Scholar
- Kumar NM, Sigurdson SL, Sheppard D, Lwebuga-Mukasa JS. Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells. Exp Cell Res 1995; 221: 385–94.
Google Scholar
- Pirila L, Heino J. Altered integrin expression in rheumatoid synovial lining type B cells: in vitro cytokine regulation of alpha 1 beta 1, alpha 6 beta 1, and alpha v beta 5 integrins. J Rheumatol 1996; 23: 1691–8.
Google Scholar
- Lin CS, Chen Y, Huynh T, Kramer R. Identification of the human _α_6 integrin gene promoter. DNA Cell Biol 1997; 8: 929–37.
Google Scholar
- Nishida K, Kitazawa R, Mizuno K et al. Identification of regulatory elements of human _α_6 integrin subunit gene. Biochem Biophys Res Commun 1997; 241: 258–63.
Google Scholar
- Sommers CL, Byers SW, Thompson EW et al. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat 1994; 31: 325–35.
Google Scholar
- Meiners S, Brinkmann V, Naundorf H, Birchmeier W. Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene 1998; 16: 9–20.
Google Scholar
- Castles CG, Klotz DM, Fuqua SAW, Hill SM. Coexpression of wildtype and variant oestrogen receptor mRNAs in a panel of human breast cancer cell lines. Br J Cancer 1995; 71: 974–80.
Google Scholar