Polyphosphorylation and Non-Enzymatic Template-Directed Ligation of Oligonucleotides (original) (raw)
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The non-enzymatic replication of oligonucleotides is a key concept in theories regarding the origin of life, particularly those that propose an RNA world. This study demonstrates that oligonucleotide 5′-polyphosphates can be formed under prebiotic conditions and can undergo template-directed ligation, suggesting a plausible pathway for the synthesis of longer oligonucleotides from shorter ones in early Earth environments.
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