Genes, isochores and bands in human chromosomes 21 and 22 (original) (raw)

Abstract

The recently available DNA sequences from chromosomes 21 and 22 enabled us to define the relationships of different band types with isochores and with gene concentration and to compare these relationships with previous results. We showed that chromosomal bands appear as Giemsa or Reverse bands depending not on their absolute GC level, but on the composition GC level relative to those of adjacent contiguous bands. We also demonstrated that the GC-richest, and gene-richest H3+ bands are characterized by a lower DNA compaction compared with the GC-poorest, gene-poorest L1+ bands. Moreover, our results indicate that the human genome contains about 30,000 genes.

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Authors and Affiliations

1. Dipartimento di Protezione e Valorizzazione Agroalimentare, University of Bologna, via F.lli Rosselli 107, 42100, Reggio Emilia, Italy
   Salvatore Saccone
2. Dipartimento di Biologia Animale, University of Catania, via Androne 81, 95124, Catania, Italy
   Salvatore Saccone & Concetta Federico
3. Institute of Molecular Genetics – Academy of Sciences of the Czech Republic, Flemingovo 2, Prague, CZ-16637, Czech Republic
   Adam Pavliček & Jan Pačes
4. Laboratoire de Génétique Mol´culaire, Institut Jacques Monod, 2 Place Jussieu, 75005, Paris, France
   Adam Pavliček & Giorgio Bernardi
5. Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Napoli, Italy
   Giorgio Bernardi

Authors

1. Salvatore Saccone
2. Adam Pavliček
3. Concetta Federico
4. Jan Pačes
5. Giorgio Bernardi

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Saccone, S., Pavliček, A., Federico, C. et al. Genes, isochores and bands in human chromosomes 21 and 22.Chromosome Res 9, 533–539 (2001). https://doi.org/10.1023/A:1012443217627

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• Issue date: October 2001
• DOI: https://doi.org/10.1023/A:1012443217627