The role of matrix metalloproteinases in squamous cell carcinomas of the head and neck (original) (raw)

• Werner JA. Aktueller Stand der Versorgung des Lymphabflusses maligner Kopf-Hals-Tumoren. Eur Arch Otorhinolaryngol Suppl I 1997;47–85.
• Gersh I, Catchpole HR. The organization of ground substance and basement membrane and its significance in tissue injury, disease and growth.Am J Anat1949; 85:457–507.
  PubMed CAS Google Scholar
• Riley WBJ, Peacock EEJ. Identification, distribution, and signifi-cance of a collagenolytic enzyme in human tissues.Proc Soc Exp Biol Med1967;124:207–10.
  PubMed CAS Google Scholar
• Juarez J, Clayman G, Nakajima M. Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamouscell-carcinoma cell lines of the oral cavity.Int J Cancer1993;55: 10–8.
  PubMed CAS Google Scholar
• Taylor AC, Levy BM, Simpson JW. Collagenolytic activity of sarcoma tissues in culture.Nature1970; 228:366–7.
  PubMed CAS Google Scholar
• Seiki M. Membrane-type matrix metalloproteinases.APMIS1999; 107:137–43.
  PubMed CAS Google Scholar
• Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis.J Natl Cancer Inst1997;89:1260–70.
  PubMed CAS Google Scholar
• Charous SJ, Stricklin GP, Nanney LB et al. Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma.Ann Otol Rhinol Laryngol1997; 106:271–8.
  PubMed CAS Google Scholar
• Duffy MJ, O'Grady P. Plasminogen activator and cancer.Eur J Cancer Clin Oncol1984;20:577–82.
  PubMed CAS Google Scholar
• Garbett EA, Reed MW, Brown NJ. Proteolysis in colorectal cancer. Mol Pathol1999;52: 140–5.
  PubMed CAS Google Scholar
• Ohashi K, Nemoto T, Nakamura K et al. Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.Cancer 2000;88:2201–9.
  PubMed CAS Google Scholar
• Sutinen M, Kainulainen T, Hurskainen T. Expression of matrix metalloproteinases (MMP-1 and-2) and their inhibitors (TIMP-1,-2 and-3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis.Br J Cancer1998; 77:2239–45.
  PubMed CAS Google Scholar
• de Coignac AB, Elson G, Delneste Y. Cloning of MMP-26. A novel matrilysin-like proteinase.Eur J Biochem 2000;267:3323–9.
  PubMed CAS Google Scholar
• Birkedal-Hansen H, Moore WG, Bodden MK. Matrix metalloproteinases: A review.Crit Rev Oral Biol Med1993;4:197–250.
  PubMed CAS Google Scholar
• John A, Tuszynski G. The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis.Pathol Oncol Res2001;7:14–23.
  Article PubMed CAS Google Scholar
• Foda HD, Zucker S. Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis.Drug Discov Today 2001;6:478–82.
  PubMed CAS Google Scholar
• Docherty AJ, Lyons A, Smith BJ. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature 1985;318:66–9.
  PubMed CAS Google Scholar
• Ichikawa Y, Yamada C, Horiki T et al. Serum matrix metalloproteinase-3 and fibrin degradation product levels correlate with clinical disease activity in rheumatoid arthritis.Clin Exp Rheumatol1998;16:533–40.
  PubMed CAS Google Scholar
• Kahari VM, Saarialho-Kere U. Matrix metalloproteinases and their inhibitors in tumour growth and invasion.AnnMed 1999;31:34–45.
  CAS Google Scholar
• Konttinen YT, Ainola M, Valleala H. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis.Ann Rheum Dis 1999;58:691–7.
  PubMed CAS Google Scholar
• Peress N, Perillo E, Zucker S. Localization of tissue inhibitor of matrix metalloproteinases in Alzheimer's disease and normal brain.J Neuropathol Exp Neurol1995;54:16–22.
  PubMed CAS Google Scholar
• Reboul P, Pelletier JP, Tardif G et al. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes.A role in osteoarthritis. J Clin Invest1996; 97: 2011–9.
  PubMed CAS Google Scholar
• Shlopov BV, Lie WR, Mainardi CL et al. Osteoarthritic lesions: involvement of three different collagenases.Arthritis Rheum1997;40: 2065–74.
  PubMed CAS Google Scholar
• Stetler-Stevenson WG, Liotta LA, Kleiner DEJ. Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis.FASEB J 1993;7:1434–41.
  PubMed CAS Google Scholar
• Kleiner DE, Stetler-Stevenson WG. Matrix metalloproteinases and metastasis.Cancer Chemother Pharmacol1999;43 Suppl: S42–S51.
  PubMed CAS Google Scholar
• Stetler-Stevenson WG, Krutzsch HC, Liotta LA. Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family.J Biol Chem1989;264:17374–8.
  PubMed CAS Google Scholar
• Sato H, Takino T, Okada Y. A matrix metalloproteinase expressed on the surface of invasive tumour cells.Nature 1994;370:61–5.
  PubMed CAS Google Scholar
• Botos I, Meyer E, Swanson SM et al. Structure of recombinant mouse collagenase-3 (MMP-13).J Mol Biol1999; 292:837–44.
  PubMed CAS Google Scholar
• Marchenko GN, Strongin AY. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors.Gene2001;265:87–93.
  PubMed CAS Google Scholar
• English WR, Puente XS, Freije JM. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.J Biol Chem2000;275: 14046–55.
  PubMed CAS Google Scholar
• Greene J, Wang M, Liu YE et al.Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. ”J Biol Chem 1996;271:30375–80.
  PubMed CAS Google Scholar
• Howard EW, Bullen EC, Banda MJ. Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2.J Biol Chem1991;266:13064–9.
  PubMed CAS Google Scholar
• Kleiner DEJ, Stetler-Stevenson WG. Structural biochemistry and activation of matrix metalloproteases.Curr Opin Cell Biol1993;5: 891–7.
  PubMed CAS Google Scholar
• Knauper V, Cowell S, Smith B. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction.J Biol Chem1997;272:7608–16.
  PubMed CAS Google Scholar
• Knauper V, Lopez-Otin C, Smith B et al.Biochemical characterization of human collagenase-3.J Biol Chem1996;271:1544–50.
  PubMed CAS Google Scholar
• Llano E, Pendas AM, Freije JP. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors.Cancer Res 1999;59: 2570–6.
  PubMed CAS Google Scholar
• Stracke JO, Hutton M, Stewart M. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. J Biol Chem2000;275:14809–16.
  PubMed CAS Google Scholar
• Brew K, Dinakarpandian D, Nagase H. Tissue inhibitors of metalloproteinases: Evolution, structure and function.Biochim Biophys Acta2000;1477:267–83.
  PubMed CAS Google Scholar
• Gomez DE, Alonso DF, Yoshiji H et al. Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions.Eur J Cell Biol1997;74:111–22.
  PubMed CAS Google Scholar
• Muller D, Breathnach R, Engelmann A. Expression of collagenaserelated metalloproteinase genes in human lung or head and neck tumours.Int J Cancer1991;48:550–6.
  PubMed CAS Google Scholar
• Walther EK, Dahlmann N, Gorgulla HT. Tumor markers in the diagnosis and follow-up of head and neck cancer: Role of CEA, CA 19–9, SCC, TK, and dTTPase.Head Neck1993;15:230–5.
  PubMed CAS Google Scholar
• Grant GM, Cobb JK, Castillo B et al. Regulation of matrix metalloproteinases following cellular transformation.J Cell Physiol1996; 167:177–83.
  PubMed CAS Google Scholar
• Ohuchi E, Imai K, Fujii Y et al. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.J Biol Chem1997;272:2446–51.
  PubMed CAS Google Scholar
• Yoshizaki T, Sato H, Maruyama Y. Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma. Cancer 1997;79:139–44.
  PubMed CAS Google Scholar
• Nakajima M, Chop AM. Tumor invasion and extracellular matrix degradative enzymes: Regulation of activity by organ factors.Semin Cancer Biol1991;2:115–27.
  PubMed CAS Google Scholar
• Sawatsubashi M, Mizokami H, Tokunaga O et al. Expression of MMP-1, TIMP-1, and type I collagen in laryngeal carcinoma.Mod Pathol1998;11:878–85.
  PubMed CAS Google Scholar
• Imai K, Yokohama Y, Nakanishi I. Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties.J Biol Chem1995;270:6691–7.
  PubMed CAS Google Scholar
• Koong AC, Denko NC, Hudson KM. Candidate genes for the hypoxic tumor phenotype.Cancer Res2000;60:883–7.
  PubMed CAS Google Scholar
• O-charoenrat P, Modjtahedi H, Rhys-Evans P et al.Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells.Cancer Res 2000;60:1121–8.
  PubMed CAS Google Scholar
• O-charoenrat P, Rhys-Evans P, Court WJ et al. Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands.Clin Exp Metastasis 1999; 17:631–9.
  PubMed CAS Google Scholar
• Tomita T, Fujii M, Tokumaru Y. Granulocyte-macrophage colonystimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.Cancer Lett2000;156:83–91.
  PubMed CAS Google Scholar
• Barrett AJ, Starkey PM. The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.Biochem J1973; 133:709–24.
  PubMed CAS Google Scholar
• Brown PD. Matrix metalloproteinase inhibitors in the treatment of cancer.Med Oncol1997;14:1–10.
  Article PubMed CAS Google Scholar
• Shofuda K, Moriyama K, Nishihashi A. Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells.J Biochem (Tokyo) 1998;124: 462–70.
  PubMed CAS Google Scholar
• Hayakawa T, Yamashita K, Tanzawa K et al. Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum.FEBS Lett 1992;298:29–32.
  PubMed CAS Google Scholar
• Uria JA, Ferrando AA, Velasco G et al. Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.Cancer Res1994;54:2091–4.
  PubMed CAS Google Scholar
• Ikebe T, Takeuchi H, Jimi E et al. Involvement of proteasomes in migration and matrix metalloproteinase-9 production of oral squamous cell carcinoma.Int J Cancer 1998; 77:578–85.
  PubMed CAS Google Scholar
• Long L, Navab R, Brodt P.Regulation of the Mr 72,000 type IV collagenase by the type I insulin-like growth factor receptor.Cancer Res1998;58:3243–7.
  PubMed CAS Google Scholar
• Mann EA, Hibbs MS, Spiro JD.Cytokine regulation of gelatinase production by head and neck squamous cell carcinoma: The role of tumor necrosis factor-alpha.Ann Otol Rhinol Laryngol1995;104: 203–9.
  PubMed CAS Google Scholar
• O-charoenrat P, Rhys-Evans P, Modjtahedi H et al. Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion.Int J Cancer2000;86:307–17.
  PubMed CAS Google Scholar
• Rooprai HK, Rucklidge GJ, Panou C et al. The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells.Br J Cancer2000;82:52–5.
  PubMed CAS Google Scholar
• Shima I, Sasaguri Y, Kusukawa J. Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor.Br J Cancer1993; 67:721–7.
  PubMed CAS Google Scholar
• Rosenthal EL, Hotary K, Bradford C et al. Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro.Otolaryngol Head Neck Surg 1999;121:337–43.
  PubMed CAS Google Scholar
• Dunsmore SE, Saarialho-Kere UK, Roby JD. Matrilysin expression and function in airway epithelium.J Clin Invest1998;102:1321–31.
  Article PubMed CAS Google Scholar
• Nielsen BS, Timshel S, Kjeldsen L. 92 kDa type IV collagenase (MMP-9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer.Int J Cancer1996; 65:57–62.
  PubMed CAS Google Scholar
• Pyke C, Ralfkiaer E, Huhtala P et al. Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.Cancer Res 1992;52:1336–41.
  PubMed CAS Google Scholar
• Nomura H, Fujimoto N, Seiki M, et al.Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas.Int J Cancer1996;69: 9–16.
  PubMed CAS Google Scholar
• Gray ST, Wilkins RJ, Yun K. Interstitial collagenase gene expression in oral squamous cell carcinoma.Am J Pathol 1992;141:301–6.
  PubMed CAS Google Scholar
• Lengyel E, Gum R, Juarez J. Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.Cancer Res1995;55:963–7.
  PubMed CAS Google Scholar
• Muller D, Wolf C, Abecassis J. Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.Cancer Res1993;53:165–9.
  PubMed CAS Google Scholar
• Tokumaru Y, Fujii M, Otani Y.Activation of matrix metalloproteinase-2 in head and neck squamous cell carcinoma: Studies of clinical samples and in vitro cell lines co-cultured with fibroblasts.Cancer Lett2000;150:15–21.
  PubMed CAS Google Scholar
• Yoshikawa T, Saitoh M, Tsuburaya A.Tissue inhibitor of matrix metalloproteinase-1 in the plasma of patients with gastric carcinoma. A possible marker for serosal invasion and metastasis.Cancer1999; 86:1929–35.
  PubMed CAS Google Scholar
• Hanzawa M, Shindoh M, Higashino F. Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes.Carcinogenesis 2000;21:1079–85.
  PubMed CAS Google Scholar
• Hida K, Shindoh M, Yoshida K.Expression of E1AF, an ets-family transcription factor, is correlated with the invasive phenotype of oral squamous cell carcinoma.Oral Oncol1997;33:426–30.
  PubMed CAS Google Scholar
• Shindoh M, Higashino F, Kaya M. Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.Am J Pathol 1996;148:693–700.
  PubMed CAS Google Scholar
• Inoue K, Slaton JW, Eve BY. Interleukin 8 expression regulates tumorigenicity and metastases in androgen-independent prostate cancer.Clin Cancer Res2000;6:2104–19.
  PubMed CAS Google Scholar
• Luca M, Huang S, Gershenwald JE et al. Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis.Am J Pathol1997;151: 1105–13.
  PubMed CAS Google Scholar
• Cazorla m, Hernandez L, Nadal A. Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.J Pathol1998;186:144–50.
  PubMed CAS Google Scholar
• Liotta LA, Rao CN, Wewer UM.Biochemical interactions of tumor cells with the basement membrane.Annu Rev Biochem1986;55: 1037–57.
  PubMed CAS Google Scholar
• MacDougall JR, Matrisian LM. Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis.Cancer Metastasis Rev1995;14:351–62.
  PubMed CAS Google Scholar
• Woodhouse EC, Chuaqui RF, Liotta LA.General mechanisms of metastasis.Cancer1997;80:1529–37.
  PubMed CAS Google Scholar
• Kurahara S, Shinohara M, Ikebe T. Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: Correlations with tumor invasion and metastasis.Head Neck 1999;21: 627–38.
  PubMed CAS Google Scholar
• Ebihara I, Nakamura T, Shimada N et al. Increased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus.Am J Kidney Dis 1998;32:544–50.
  PubMed CAS Google Scholar
• Kai H, Ikeda H, Yasukawa H. Peripheral blood levels of matrix metalloproteases-2 and-9 are elevated in patients with acute coronary syndromes.J Am Coll Cardiol 1998; 32: 368–72.
  PubMed CAS Google Scholar
• Adachi Y, Itoh F, Yamamoto H. Matrix metalloproteinase matrilysin (MMP-7) participates in the progression of human gastric and esophageal cancers.Int J Oncol1998;13:1031–5.
  PubMed CAS Google Scholar
• Adachi Y, Yamamoto H, Itoh F et al. Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers.Gut 1999;45:252–8.
  Article PubMed CAS Google Scholar
• Parsons SL, Watson SA, Brown PD et al. Matrix metalloproteinases. Br J Surg1997;84:160–6.
  PubMed CAS Google Scholar
• Yoshikawa T, Tsuburaya A, Kobayashi O. Prognostic value of tissue inhibitor of matrix metalloproteinase-1 in plasma of patients with gastric cancer.Cancer Lett 2000;151:81–6.
  PubMed CAS Google Scholar
• Mimori K, Mori M, Shiraishi T.Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma.Br J Cancer1997;76:531–6.
  PubMed CAS Google Scholar
• Gullu IH, Kurdoglu M, Akalin I. The relation of gelatinase (MMP-2 and-9) expression with distant site metastasis and tumour aggressiveness in colorectal cancer.Br J Cancer2000;82:249.
  PubMed CAS Google Scholar
• Garbisa S, Scagliotti G, Masiero L. Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy. Cancer Res 1992;52:4548–9.
  PubMed CAS Google Scholar
• Ylisirnio S, Hoyhtya M, Turpeenniemi-Hujanen T. Serum matrix metalloproteinases-2,-9 and tissue inhibitors of metalloproteinases-1,-2 in lung cancer–TIMP-1 as a prognostic marker.Anticancer Res 2000;20:1311–6.
  PubMed CAS Google Scholar
• Parsons SL, Watson SA, Collins HM et al. Gelatinase (MMP-2 and-9) expression in gastrointestinal malignancy.Br J Cancer1998;78: 1495–502.
  PubMed CAS Google Scholar
• Zeng ZS, Cohen AM, Guillem JG. Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis.Carcinogenesis1999;20:749–55.
  PubMed CAS Google Scholar
• Zeng ZS, Guillem JG. Unique activation of matrix metalloproteinase-9 within human liver metastasis from colorectal cancer.Br J Cancer1998;78:349–53.
  PubMed CAS Google Scholar
• Iizasa T, Fujisawa T, Suzuki M. Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients. Clin Cancer Res1999;5:149–53.
  PubMed CAS Google Scholar
• Kanayama H, Yokota K, Kurokawa Y et al.Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer.Cancer1998;82:1359–66.
  PubMed CAS Google Scholar
• Johansson N, Vaalamo M, Grenman S.Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. Am J Pathol1999;154:469–80.
  PubMed CAS Google Scholar
• Gohji K, Fujimoto N, Komiyama T. Elevation of serum levels of matrix metalloproteinase-2 and-3 as new predictors of recurrence in patients with urothelial carcinoma.Cancer1996;78:2379–87.
  PubMed CAS Google Scholar
• Gohji K, Fujimoto N, Ohkawa J et al.Imbalance between serum matrix metalloproteinase-2 and its inhibitor as a predictor of recurrence of urothelial cancer.Br J Cancer1998;77:650–5.
  PubMed CAS Google Scholar
• Moses MA, Wiederschain D, Loughlin KR et al. Increased incidence of matrix metalloproteinases in urine of cancer patients.Cancer Res 1998;58:1395–9.
  PubMed CAS Google Scholar
• Gohji K, Fujimoto N, Hara I. Serum matrix metalloproteinase-2 and its density in men with prostate cancer as a new predictor of disease extension.Int J Cancer1998;79:96–101.
  PubMed CAS Google Scholar
• Shima I, Sasaguri Y, Kusukawa J. Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma. A clinicopathologic study.Cancer 1992;70:2747–53.
  PubMed CAS Google Scholar
• Yamashita K, Mori M, Shiraishi T et al. Clinical significance of matrix metalloproteinase-7 expression in esophageal carcinoma.Clin Cancer Res2000;6:1169–74.
  PubMed CAS Google Scholar
• Kusukawa J, Sasaguri Y, Shima I et al. Production of matrix metalloproteinase 2 (gelatinase/type IV collagenase) and 3 (stromelysin) by cultured oral squamous cell carcinoma.J Oral Pathol Med1992; 21:221–4.
  PubMed CAS Google Scholar
• Polette m, Clavel C, Birembaut P et al. Localization by in situ hybridization of mRNAs encoding stromelysin 3 and tissue inhibitors of metallo-proteinases TIMP-1 and TIMP-2 in human head and neck carcinomas.Pathol Res Pract1993;189:1052–7.
  PubMed CAS Google Scholar
• Polette M, Clavel C, Muller D et al. Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization.Invasion Metastasis1991;11:76–83.
  PubMed CAS Google Scholar
• Magary SP, Ryan MW, Tarnuzzer RW et al.Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in laryngeal and pharyngeal squamous cell carcinoma: A quantitative analysis.Otolaryngol Head Neck Surg2000;122:712–6.
  PubMed CAS Google Scholar
• Villaret DB, Wang T, Dillon D. Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis. Laryngoscope2000;110:374–81.
  PubMed CAS Google Scholar
• Kawamata H, Nakashiro K, Uchida D et al. Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.Int J Cancer1997;70:120–7.
  PubMed CAS Google Scholar
• Kawamata H, Uchida D, Hamano H. Active-MMP2 in cancer cell nests of oral cancer patients: Correlation with lymph node metastasis. Int J Oncol1998;13:699–704.
  PubMed CAS Google Scholar
• Miyajima Y, Nakano R, Morimatsu M. Analysis of expression of matrix metalloproteinases-2 and-9 in hypopharyngeal squamous cell carcinoma by in situ hybridization.Ann Otol Rhinol Laryngol1995; 104:678–684.
  PubMed CAS Google Scholar
• Tokumaru Y, Fujii M, Otani Y et al. Activation of matrix metalloproteinase-2 in head and neck squamous cell carcinoma: Studies of clinical samples and in vitro cell lines co-cultured with fibroblasts.Cancer Lett2000;150:15–21.
  PubMed CAS Google Scholar
• Kusukawa J, Sasaguri Y, Morimatsu M, Kameyama T et al. Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity.J Oral Maxillofac Surg1995;53:530–4.
  PubMed CAS Google Scholar
• Arenas-Huertero FJ, Herrera-Goepfert R, Delgado-Chavez R. Matrix metalloproteinases expressed in squamous cell carcinoma of the oral cavity: Correlation with clinicopathologic features and neo-adjuvant chemotherapy response. J Exp Clin Cancer Res1999;18:279–84.
  PubMed CAS Google Scholar
• Burian M, Quint C, Neuchrist C. Angiogenic factors in laryngeal carcinomas: Do they have prognostic relevance?Acta Otolaryngol 1999;119:289–92.
  PubMed CAS Google Scholar
• Okada A, Bellocq JP, Rouyer N. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.Proc Natl Acad Sci USA1995;92:2730–4.
  PubMed CAS Google Scholar
• Hofmann UB, Westphal JR, Zendman AJ et al. Expression and activation of matrix metalloproteinase-2 (MMP-2) and its colocalization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression.J Pathol2000;191: 245–56.
  PubMed CAS Google Scholar
• Knauper V, Will H, Lopez-Otin C. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem1996;271:17124–31.
  PubMed CAS Google Scholar
• Falkenberg S, Rathcke IO, Lippert BM et al. Expression of MMP-2,-7,-9, and-13 as well as TIMP-1,-2, and-3 in squamous cell carcinomas of the head and neck.J Cancer Res Clin Oncol1999; 125:122.
  Google Scholar
• Heissenberg MC, Gorogh T, Lippert BM et al. Metalloproteinases and their inhibitors in squamous cell carcinoma of the hypopharynx: indicators of individual tumor aggressiveness.Otolaryngol Pol1998; 52:521–6.
  PubMed CAS Google Scholar
• Ikebe T, Shinohara M, Takeuchi H. Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer.Clin Exp Metastasis1999;17:315–23.
  PubMed CAS Google Scholar
• Riedel F, Gotte K, Schwalb J et al. Expression of 92-kDa type IV collagenase correlates with angiogenic markers and poor survival in head and neck squamous cell carcinoma.Int J Oncol2000;17:1099–105.
  PubMed CAS Google Scholar
• Johansson N, Airola K, Grenman R et al. Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.Am J Pathol1997;151:499–508.
  PubMed CAS Google Scholar
• Repassy G, Forster-Horvath C, Juhasz A et al. Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma.Pathol Oncol Res1998;4:14–21.
  Article PubMed CAS Google Scholar
• Maass J, Koch R, Gottschlich S et al. MMP-13 in oropharyngeal squamous cell carcinoma.Laryngorhinootologie2000; Supplement 1:180
• Imanishi Y, Fujii M, Tokumaru Y et al.Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.Hum Pathol2000;31:895–904.
  PubMed CAS Google Scholar
• Kusukawa J, Harada H, Shima I et al. The significance of epidermal growth factor receptor and matrix metalloproteinase-3 in squamous cell carcinoma of the oral cavity.Eur J Cancer B Oral Oncol1996; 32B:217–21.
  PubMed CAS Google Scholar
• Yamamoto H, Adachi Y, Itoh F. Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma.Cancer Res1999;59:3313–6.
  PubMed CAS Google Scholar
• Shinohara M, Nakamura S, Harada T et al. Mode of tumor invasion in oral squamous cell carcinoma: Improved grading based on immunohistochemical examination of extracellular matrices.Head Neck1996;18:153–9.
  PubMed CAS Google Scholar
• Dietz A, Rudat V, Vanselow B et al. Prognostische Bedeutung von bFGF, VEGF und MMP-2 im Serum von Patienten mit fortgeschrittenen Kopf-Hals-Tumoren.HNO1999; 47:695–701.
  PubMed CAS Google Scholar
• Riedel F, Gotte K, Schwalb J et al. Serum levels of matrix metalloproteinase-2 and-9 in patients with head and neck squamous cell carcinoma.Anticancer Res2000;20:3045–9.
  PubMed CAS Google Scholar
• Zucker S, Hymowitz M, Conner C. Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications.Ann NY Acad Sci 1999;878:212–27.
  PubMed CAS Google Scholar
• Maekawa R, Maki H, Yoshida H. Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor.Cancer Res1999;59:1231–5.
  PubMed CAS Google Scholar
• Pendas AM, Uria JA, Jimenez MG et al. An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.Clin Chim Acta2000;291:137–55.
  PubMed CAS Google Scholar
• Wojtowicz-Praga SM, Dickson RB, Hawkins MJ. Matrix metalloproteinase inhibitors.Invest New Drugs 1997;15:61–75.
  PubMed CAS Google Scholar
• Natchus MG, Bookland RG, Laufersweiler MJ et al.Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.J Med Chem 2001;44:1060–71.
  PubMed CAS Google Scholar
• Wu Y, Palad AJ, Wasilenko WJ. Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole.Clin Cancer Res1997;3:1915–21.
  PubMed CAS Google Scholar
• Dünne AA, Külkens C, Ramaswamy A et al.Value of sentinel lymphonodectomy in patients with squamous cell carcinoma of the head and neck.Auris Nasus Larynx2001;28:339–44.
  PubMed Google Scholar
• Werner JA, Dünne AA, Ramaswamy A et al. Number and location of radiolabeled, intraoperatively identified sentinel nodes in 48 head and neck cancer patients with clinically staged N0 and N1 neck.Eur Arch Otorhinolaryngol (in press).
• Dünne AA, Plehn S, Schulz S et al. Lymph node topography of the head and neck in New Zealand white rabbits.Lab Animals (in press).
• Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior.Annu Rev Cell Dev Biol2001;17:463–516.
  PubMed CAS Google Scholar