NF-kappaB and Apoptosis in Mammary Epithelial Cells (original) (raw)
REFERENCES
G. W. Robinson, P. F. Johnson, L. Hennighausen, E. Sterneck (1998). The c/ebp beta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev. **12:**1907–1916. Google Scholar
X. W. Liu, G. W. Robinson, K. U. Wagner, L. Garrett, A. Wynshaw-Boris, L. Hennighausen (1997). Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. **11:**179–186. Google Scholar
T. N. Seagroves, S. Krnacik, B. Raught, J. Gay, B. Burgess-Beusse, G. J. Darlington, J. M. Rosen (1998). C/ebp beta, but not c/ebp alpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. **12:**1917–1928. Google Scholar
A. Fraser and G. Evan (1996). A license to kill. Cell85: 781–784. Google Scholar
E. Bossy-Wetzel, L. Bakiri, and M. Yaniv (1997). Induction of apoptosis by the transcription factor c-jun. EMBO J. **16:**1695–1709. Google Scholar
H. Steller (1995). Mechanisms and genes of cellular suicide. Science **267:**1445–1449. Google Scholar
L. J. Miller and J. Marx (1998). Apoptosis: Special review series. Science **281:**1301 Google Scholar
R. Sen and D. Baltimore (1986). Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell46: 705–716. Google Scholar
T. Collins (1993). Biology of disease—endothelial nuclear factor-kappa-b and the initiation of the atherosclerotic lesion. Lab. Invest. **68:**499–508. Google Scholar
S. Ghosh, M. J. May, and E. B. Kopp (1998). NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Ann. Rev. Immunol. **16:**225–260. Google Scholar
M. Karin (1998). The NF-kappa B activation pathway: Its regulation and role in inflammation and cell survival. Cancer J. Sci. Amer. **4:**S92–S99. Google Scholar
S. Gerondakis, R. Grumont, I. Rourke, M. Grossmann (1998). The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation. Current Opin. Immunol. **10:**353–359. Google Scholar
M. J. May and S. Ghosh (1998). Signal transduction through NF-kappa B. Immunol. Today **19:**80–88. Google Scholar
C. Kunsch, S. M. Ruben, and C. A. Rosen (1992). Selection of optimal kappa-B/Rel DNA-binding motifs-interaction of both subunits of NF-kappa-B with DNA is required for transcriptional activation. Mol. Cell. Biol. **12:**4412–4421. Google Scholar
V. Imbert, R. A. Rupec, A. Livolsi, H. L. Pahl, E. B. M. Traenckner, C. MuellerDieckmann, D. Farahifar, B. Rossi, P. Auberger, P. A. Baeuerle, J.-F. Peyron (1996). Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell **86:**787–798. Google Scholar
M. Naumann and C. Scheidereit (1994). Activation of NF-kappa-B in vivo is regulated by multiple phosphorylations. EMBO J. **13:**4597–4607. Google Scholar
H. H. Zhong, H. Su Yang, H. Erdjument-Bromage, P. Tempst, and S. Ghosh (1997). The transcriptional activity of nf-kappa b is regulated by the I kappa B-associated PKAC subunit through a cyclic AMP-independent mechanism. Cell **89:**413–424. Google Scholar
B. Stein, P. C. Cogswell, and A. S. Baldwin (1993). Functional and physical associations between NF-kappa-B and c/ebp family members—a Rel domain-bZIP interaction. Mol. Cell. Biol. **13:**3964–3974. Google Scholar
B. Stein and A. S. Baldwin (1993). Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between c/ebp and NF-kappa-B. Mol. Cell. Biol. **13:**7191–7198. Google Scholar
R. I. Scheinman, A. Gualberto, C. M. Jewell, J. A. Cidlowski, and A. S. Baldwin (1995). Characterization of mechanisms involved in transrepression of NF-kappa-B by activated glucocorticoid receptors. Mol. Cell. Biol. **15:**943–953. Google Scholar
A. A. Beg, W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa-B. Nature **376:**167–170. Google Scholar
W. C. Sha, H. C. Liou, E. I. Tuomanen, and D. Baltimore (1995). Targeted disruption of the p50 subunit of NF-kappa-B leads to multifocal defects in immune-response s. Cell80: 321–330. Google Scholar
F. Weih, D. Carrasco, S. K. Durham, D. S. Barton, C. A. Rizzo, R. P. Ryseck, S. A. Lira, and R. Bravo (1995). Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa-B/Rel family. Cell **80:**331–340. Google Scholar
C. Abbadie, N. Kabrun, F. Bouali, J. Smardova, D. Stehelin, B. Vandenbunder, and P. J. Enrietto (1993). High-levels of c-Rel expression are associated with programmed cell-death in the developing avian embryo and in bone-marrow cells in vitro. Cell **75:**899–912. Google Scholar
P. A. Baeuerle and D. Baltimore (1996) NF-kappa B: Ten years after. Cell **87:**13–20. Google Scholar
D. J. VanAntwerp, S. J. Martin, I. M. Verma, and D. R. Green (1998). Inhibition of TNF-induced apoptosis by NF-kappa B. Trends Cell Biol. **8:**107–111. Google Scholar
S. Grimm, M. K. A. Bauer, P. A. Baeuerle, and K. Schulze-Osthoff (1996). Bcl-2 down-regulates the activity of transcription factor NF-kappa B induced upon apoptosis. J. Cell Biol. **134:**13–23. Google Scholar
D. J. VanAntwerp, S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma (1996). Suppression of TNF-alpha-induced apoptosis by NF-kappa B. Science **274:**787–789. Google Scholar
C. Y. Wang, M. W. Mayo, and A. S. Baldwin (1996). TNF-and career therapy-induced apoptosis: Potentiation by inhibition of NF-kappa-B. Science **274:**784–787. Google Scholar
K. Brown, S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist (1995). Control of I-kappa-B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science267: 1485–1488. Google Scholar
A. A. Beg and D. Baltimore (1996). An essential role for NF-kappa B in preventing tnf-alpha-induced cell death. Science **274:**782–784. Google Scholar
D. Wallach (1997). Cell death induction by TNF: A matter of self control. Trends Biochem. Sci. **22:**107–109. Google Scholar
C. Y. Wang, M. W. Mayo, R. G. Korneluk, D. V. Goeddel, and A. S. Baldwin (1998). NF-kappa B antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science **281:**1680–1683. Google Scholar
M. Wu, M. Arsura, R. E. Bellas, M. J. Fitzgerald, H. Y. Lee, S. L. Schauer, D. H. Sherr, and G. E. Sonenshein (1996). Inhibition of c-myc expression induces apoptosis of WEHI231 murine B cells. Mol. Cell. Biol. **16:**5015–5025. Google Scholar
H. Y. Wu and G. Lozano (1994). NF-kappa-B activation of p53—a potential mechanism for suppressing cell-growth in response to stress. J. Biol. Chem. **269:**20067–20074. Google Scholar
R. Strange, F. Li, S. Saurer, A. Burkhardt, and R. R. Friis (1992). Apoptotic cell-death and tissue remodeling during mouse mammary-gland involution. Development **115:**49–58. Google Scholar
G. R. Merlo, F. Basolo, L. Fiore, L. Duboc, and N. E. Hynes (1995). P53–dependent and p53–independent activation of apoptosis in mammary epithelial-cells reveals a survival function of EGF and insulin. J. Cell Biol. **128:**1185–1196. Google Scholar
N. Boudreau, Z. Werb, and M. J. Bissell (1996). Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc. Natl. Acad. Sci. U.S.A. **93:**3509–3513. Google Scholar
D. Carrasco, F. Weih, and R. Bravo (1994). Developmental expression of the mouse c-Rel protooncogene in hematopoietic organs. Development **120:**2991–3004. Google Scholar
R. Schmidt-Ullrich, S. Memet, A. Lilienbaum, J. Feuillard, M. Raphael, and A. Israel (1996). NF-kappa B activity in transgenic mice: Developmental regulation and tissue specificity. Development **122:**2117–2128. Google Scholar
P. B. Bushdid, D. M. Brantley, F. E. Yull, G. L. Blaeuer, L. H. Hoffman, and L. Niswander, L. D. Kerr (1998). Inhibition of NF-kappa B activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature **392:**615–618. Google Scholar
Y. Kanegae, A. T. Tavares, J. C. I. Belmonte, and I. M. Verma (1998). Role of Rel/NF-kappa B transcription factors during the outgrowth of the vertebrate limb. Nature **392:**611–614. Google Scholar
C. S. Seitz, Q. Lin, H. Deng, and P. A. Khavari (1998). Alterations in NF-kappa B function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappa B. Proc. Natl. Acad. Sci. U.S.A. **95:**2307–2312. Google Scholar
M. A. Sovak, R. E. Bellas, D. W. Kim, G. J. Zanieski, A. E. Rogers, A.M. Traish, and G.E. Sonenshein (1997). Aberrant nuclear factor-kappa B/Rel expression and the pathogenesis of breast cancer. J. Clin. Invest. **100:**2952–2960. Google Scholar
B. Stein, A. S. Baldwin, D. W. Ballard, W. C. Greene, P. Angel, and P. Herrlich (1993). Cross-coupling of the NF-beta-B p65 and fos jun transcription factors produces potentiated biological function. EMBO J. **12:**3879–3891. Google Scholar
E. Dejardin, G. Bonizzi, A. Bellahcene, V. Castronovo, M. P. Merville, and V. Bours (1995). Highly-expressed p100/p52 (nfkb2) sequesters other NF-kappa-B-related proteins in the cytoplasm of human breast-cancer cells. Oncogene **11:**1835–1841. Google Scholar
H. Nakshatri, P. Bhat-Nakshatri, D. A. Martin, R. J. Goulet, and G. W. Sledge (1997). Constitutive activation of NF-kappa B during progression of breast cancer to hormone-indepen dent growth. Mol. Cell. Biol. **17:**3629–3639. Google Scholar
D. Adam, U. Kessler, and M. Kronke (1995). Cross-linking of the p55 tumor-necrosis-factor receptor cytoplasmic domain by a dimeric ligand induces nuclear factor-kappa-B and mediates cell-death. J. Biol. Chem. **270:**17482–17487. Google Scholar
Z. Z. Cai, M. Korner, N. Tarantino, and S. Chouaib (1997). I kappa B alpha overexpression in human breast carcinoma mcf7 cells inhibits nuclear factor-kappa B activation but not tumor necrosis factor-alpha-induced apoptosis. J. Biol. Chem.272: 96–101. Google Scholar
M. C. Raff (1992). Social controls on cell-survival and cell-death. Nature **356:**397–400. Google Scholar
M. L. Li, X. W. Liu, G. Robinson, U. Bar-Peled, K. U. Wagner, W. S. Young, L. Hennighausen, and P. A. Furth (1997). Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc. Natl. Acad. Sci. U.S.A. **94:**3425–3430. Google Scholar
K. Hishikawa, B. S. Oemar, Z. H. Yang, and T. F. Luscher (1997). Pulsatile stretch stimulates superoxide production and activates nuclear factor-kappa B in human coronary smooth muscle. Circulation Res. **81:**797–803. Google Scholar
M. Scatena, M. Almeida, M. L. Chaisson, N. Fausto, R. F. Nicosia, and C. M. Giachelli (1998). NF-kappa B mediates alpha v beta 3 integrin-induc ed endothelial cell survival. J. Cell Biol. **141:**1083–1093. Google Scholar
D. Ramarli, M. T. Scupoli, E. Fiorini, O. Poffe, M. Brentegani, A. Villa, G. Cecchini, G. Tridente, and P. C. Marchisio (1998). Thymocyte contact or monoclonal antibody-mediated clustering of alpha 3 beta 1 or alpha 6 beta 4 integrins activate interleukin-6 (IL-6) transcription factors (NF-kappa B and NF-IL6) and IL-6 production in human thymic epithelial cells. Blood **92:**3745–3755. Google Scholar
J. H. Xu, M. M. Zutter, S. A. Santoro, and R. A. F. Clark (1998). A three-dimensional collagen lattice activates NF-kappa B in human fibroblasts: Role in integrin alpha(2) gene expression and tissue remodeling. J. Cell Biol. **140:**709–719. Google Scholar
A. Bearz, G. Tell, A. Colombatti, S. Formisano, and C. Pucillo (1998). Fibronectin binding promotes a PKC-dependent modulation of NF-kappa B in human T cells. Biochem. Biophys. Res. Commun. **243:**732–737. Google Scholar
J. D. Li, W. J. Feng, M. Gallup, J. H. Kim, J. Gum, Y. Kim, and C. Basbaum (1998). Activation of NF-kappa B via a src-dependent ras-mapk-pp90rs k pathway is required for pseudomonas aeruginosa-induce d mucin overproduction in epithelial cells. Proc. Natl. Acad. Sci. U.S.A. **95:**5718–5723. Google Scholar
D. M. Eicher, T. H. Tan, N. R. Rice, J. J. Oshea, and I. C. S. Kennedy (1994). Expression of v-src in T-cells correlates with nuclear expression of NF-kappa-B. J. Immunol. **152:**2710–2719. Google Scholar
A. K. Andersson and S. Sandler (1998). Involvement of PI-3 kinase in IL-1 beta induced activation of NF kappa B in beta-cells. Diabetologia **41:**606 Google Scholar
A. P. Soler, C. W. Marano, M. Bryans, R. D. Miller, L. A. Garulacan, S. K. Mauldin, V. Poltoratsky, T. D. Stamato, and I. M. Mullin (1997). Curcumin alters the barrier function of an epithelium undergoing TNF-induced apoptosis by inhibiting PI-3 kinase and NF-kappa B activation. FASEB J. **11:**2987. Google Scholar
R. Narayanan, K. A. Higgins, J. R. Perez, T. A. Coleman, and C. A. Rosen (1993). Evidence for differential functions of the p50 and p65 subunits of NF-kappa-B with a cell-adhesion model. Mol. Cell. Biol. **13:**3802–3810. Google Scholar
R. Perona, S. Montaner, L. Saniger, I. SanchezPerez, R. Bravo, and J. C. Lacal (1997). Activation of the nuclear factor-kappa B by rho, cdc42, and rac-1 proteins. Genes Dev. **11:**463–475. Google Scholar
M. Spiecker, H. B. Peng, and J. K. Liao (1997). Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of I kappa B alpha. J. Biol. Chem. **272:**30969–30974. Google Scholar
L. Cominacini, U. Garbin, A. F. Pasini, T. Paulon, A. Davoli, M. Campagnola, E. Marchi, A. M. Pastorino, G. Gaviraghi, and V. LoCascio (1997). Lacidipine inhibits the activation of the transcription factor NF-kappa B and the expression of adhesion molecules induced by pro-oxidant signals on endothelial cells. J. Hypertension **15:**1633–1640. Google Scholar
J. H. Chen, C. Vercamer, Z. L. Li, D. Paulin, B. Vandenbunder, and D. Stehelin (1996). Pea3 transactivates vimentin promoter in mammary epithelial and tumor cells. Oncogene13: 1667–1675. Google Scholar
C. Jobin, C. Hellerbrand, L. L. Licato, D. A. Brenner, and R. B. Sartor (1998). Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gut **42:**779–787. Google Scholar
I. Kurose, H. Saito, S. Miura, H. Ebinuma, H. Higuchi, N. Watanabe, S. Zeki, T. Nakamura, M. Takaishi, and H. Ishii (1997). Cd18/icam-1–dependent oxidative NF-kappa B activation leading to nitric oxide production in rat kupffer cells cocultured with syngeneic hepatoma cells. J. Clin. Invest.99: 867–878. Google Scholar
A. S. Gukoyskaya, I. Y. Gukovsky, S. Periskic, T. Blinman, V. Zaninovich, and S. J. Pandol (1997). Loss of extracellular matrix contacts leads to NF-kb activation, cytokine expression, and production and apoptosis in pancreatic acinar cell. Gastroenterology **112:**A446. Google Scholar
C. H. Yang, A. Murti, and L. M. Pfeffer (1998). Stat3 complements defects in an interferon-resistant cell line: Evidence for an essential role for Stat3 in interferon signaling and biological activities. Proc. Natl. Acad. Sci. U.S.A. **95:**5568–5572. Google Scholar
V. A. Fadok, D. R. Voelker, P. A. Campbell, J. J. Cohen, D. L. Bratton, and P. M. Henson (1992). Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. **148:**2207–2216. Google Scholar
N. Boudreau, C. J. Sympson, Z. Werb, and M. J. Bissell (1995). Suppression of ice and apoptosis in mammary epithelial-cells by extracellular-matrix. Science **267:**891–893. Google Scholar
M. M. Faraldo, M. A. Deugnier, M. Lukashev, J. P. Thiery, and M. A. Glukhova (1998). Perturbation of beta 1–integrin function alters the development of murine mammary gland. EMBO J. **17:**2139–2147. Google Scholar
R. E. Ellis, J. Y. Yuan, and H. R. Horvitz (1991). Mechanisms and functions of cell-death. Ann. Rev. Cell Biol. **7:**663–698. Google Scholar
J. A. C. Philp, T. G. Burdon, and C. J. Watson (1996). Differential activation of Stats 3 and 5 during mammary gland development. FEBS Lett. **396:**77–80. Google Scholar
K. U. Wagner, R. J. Wall, L. St. Onge, P. Gruss, A. Wynshaw-Boris, L. Garrett, M. L. Li, P. A. Furth, and L. Hennighausen (1997). Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. **25:**4323–4330. Google Scholar
S. Selbert, D. J. Bentley, D. W. Melton, D. Rannie, P. Lourenco, C. J. Watson, and A. R. Clarke (1998). Efficient blg-cre mediated gene deletion in the mammary gland. Transgenic Res. **7:**387–396. Google Scholar