A pooled analysis of case–control studies of thyroid cancer. VII. Cruciferous and other vegetables (International) (original) (raw)
Abstract
OBJECTIVE: To investigate the association between cruciferous and other vegetables and thyroid cancer risk we systematically reanalyzed the original data from 11 case–control studies conducted in the US, Asia, and Europe.
METHODS: A total of 2241 cases (1784 women, 457 men) and 3716 controls (2744 women, 972 men) were included. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated for each study by logistic regression models, conditioned on age and sex, and adjusted for history of goiter, thyroid nodules or adenomas, and radiation. Summary ORs for all studies combined were computed as the weighted average of the estimates from each study.
RESULTS: A decreased risk for the highest level of cruciferous vegetable intake, as compared to the lowest, was observed in Los Angeles, Hawaii, Connecticut, southeastern Sweden, Tromsø, and Switzerland; the OR were above unity in Japan and Uppsala, whereas no material association was found in northern Sweden, Italy, or Greece. The OR values for all studies combined were 0.87 (95% CI 0.75–1.01) for moderate and 0.94 (95% CI 0.80–1.10) for high cruciferous vegetables intake. The results were similar in studies from iodine-rich areas and endemic goiter areas, and were consistent when the analysis was restricted to papillary carcinomas and women. The summary OR values for vegetables other than cruciferous were 1.04 (0.88–1.22) for moderate and 0.82 (0.69–0.98) for high consumption.
CONCLUSIONS: This combined analysis indicates that cruciferous vegetables are not positively related to thyroid cancer risk. Their effect does not seem to be substantially different from that of other vegetables, which appear to be protective on this cancer.
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- Maria Rosaria Galanti
Present address: Tobacco Prevention Centre, SE-141 57, Huddinge, Sweden)
Authors and Affiliations
- Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, 62, 20157, Milan, Italy
Cristina Bosetti, Eva Negri & Carlo La Vecchia - Laboratory of General Epidemiology, Istituto di Ricerche Farmacologiche “, Mario Negri”, Via Eritrea, 62 - 20157, Milan, Italy
Eva Negri - Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, 96813, USA
Laurence Kolonel - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, 6120 Executive Boulevard, Rockville, MD, 20852, USA
Elaine Ron, Elaine Ron, Steven D. Mark & Charles Land - Field and Intervention Studies Unit, International Agency for Research on Cancer, 693702, Lyon Cedex 08, France
Silvia Franceschi - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033-0800, USA
Susan Preston-Martin - Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA
Anne McTiernan - Centro di Riferimento Oncologico, 33081, Aviano, PN, Italy
Luigino Dal Maso - Radiation Effects Research Foundation, Hiroshima, 732, Japan
Kiyoiko Mabuchi & Charles Land - Shanghai Cancer Institute, Shanghai, People's Republic of China, China
Fan Jin - Division of Occupational and Environmental Medicine, Department of Health and Environment, Faculty of Health Sciences, Linköping University, SE-581 85, Linköping, Sweden
Gun Wingren - Department of Cancer Epidemiology, University Hospital, SE-57185, Uppsala, Sweden
Maria Rosaria Galanti - Department of Oncology, Karolinska Institute and Stockholms Sjukhem, SE-112 35, Stockholm, Sweden
Arne Hallquist - Cancer Registry of Norway, Montebello, NO-3010, Oslo, Norway
Eystein Glattre - Institute of Community Medicine, University of Tromsø, NO-9037, Tromsø, Norway
Eiliv Lund - Registre Vaudois des Tumeurs, Institut universitaire de mèdecine sociale et prèventive, CH-1011, Lausanne, Switzerland
Fabio Levi - Institute of Preventive Medicine, GR-145 61, Kifissia, Greece
Dimitrios Linos - Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, 20133, Milan, Italy
Carlo La Vecchia
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Bosetti, C., Negri, E., Kolonel, L. et al. A pooled analysis of case–control studies of thyroid cancer. VII. Cruciferous and other vegetables (International).Cancer Causes Control 13, 765–775 (2002). https://doi.org/10.1023/A:1020243527152
- Issue Date: October 2002
- DOI: https://doi.org/10.1023/A:1020243527152