Chemokines as Molecular Targets for Therapeutic Intervention (original) (raw)
REFERENCES
Baggiolini M: Chemokines and leukocyte traffic. Nature 392:565–568, 1998 Google Scholar
Zlotnik A, Morales J, Hedrick JA: Recent advances in chemokines and chemokine receptors. Crit Rev Immunol 19:1–47, 1999 Google Scholar
Rollins BJ: Chemokines. Blood 90:909–928, 1997 Google Scholar
Howard OM, Ben-Baruch A, Oppenheim JJ: Chemokines: progress toward identifying molecular targets for therapeutic agents. Trends Biotechnol 14:46–51, 1996 Google Scholar
Yang D, Chertov O, Bykovskaia S, et al.: Human beta-defensins promote adaptive immunity, by activating dendritic and T cells expressing CCR6. Science (in press)
Oppenheim JJ, Wang JM, Chertov O, et al.: The role of chemokines in transplantation. In Transplant Biology, NL Tilney, TB Storm, LC Paul (eds). Philadelphia, Lippincott-Raven, 1996, pp 187–220 Google Scholar
Littman DR: Chemokine receptors: Keys to AIDS pathogenesis? Cell 93:677–680, 1998 Google Scholar
Kledal TN, Rosenkilde MM, Coulin F, et al.: A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 277:1656–1659, 1997 Google Scholar
Yang X-D, Corvalan JRS, Wang T, et al.: Fully human anti IL-8 monoclonal antibody: Potential therapeutics for the treatment of inflammatory disease states. J Leukocyte Biol 66:401–410, 1999 Google Scholar
Harada A, Sekido N, Akahoshi T, et al.: Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukocyte Biol 56:559–564, 1994 Google Scholar
Matsumoto T, Yokoi K, Mukaida N, et al.: Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury. J Leukocyte Biol 62:581–587, 1997 Google Scholar
Ono K, Matsumori A, Furukawa Y, et al.: Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Lab Invest 79:195–203, 1999 Google Scholar
Lloyd C, Gutierrez-Ramos JC: The role of chemokines in tissue inflammation and autoimmunity in renal diseases. Curr Opin Nephrol Hypertens 7:281–287, 1998 Google Scholar
Arenberg DA, Kunkel SL, Polverini PJ, et al.: Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice. J Clin Invest 97:2792–2802, 1996 Google Scholar
Karpus WJ, Kennedy KJ: MIP-lalpha and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. J Leukoc Biol 62:681–768, 1997 Google Scholar
Greenberger MJ, Strieter RM, Kunkel SL, et al.: Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia. J Infect Dis 173:159–165, 1996 Google Scholar
Moser B, Dewald B, Barella L, et al.: Interleukin-8 antagonists generated by N-terminal modification. J Biol Chem 268:7125–7158, 1993 Google Scholar
Baly DL, Horuk R, Yansura DG, et al.: A His19 to Ala mutant of melanoma growth-stimulating activity is a partial antagonist of the CXCR2 receptor. J Immunol 161:4944–4949, 1998 Google Scholar
Hayashi S, Kurdowska A, Miller EJ, et al.: Synthetic hexa-and heptapeptides that inhibit IL-8 from binding to and activating human blood neutrophils. J Immunol 154:814–824, 1995 Google Scholar
Miller EJ, Cohen AB, Peterson BT: Peptide inhibitor of interleukin-8 (IL-8) reduces staphylococcal enterotoxin-A (SEA) induced neutrophil trafficking to the lung. Inflamm Res 45:393–397, 1996 Google Scholar
Hayashi S, Kurdowska A, Cohen AB, et al.: A synthetic peptide inhibitor for alpha-chemokines inhibits the growth of melanoma cell lines. J Clin Invest 99:2581–2587, 1997 Google Scholar
Fujisawa N, Hayashi S, Miller EJ: A synthetic peptide inhibitor for alpha-chemokines inhibits the tumour growth and pulmonary metastasis of human melanoma cells in nude mice [in process citation]. Melanoma Res 9:105–114, 1999 Google Scholar
Fujisawa N, Hayashi S, Kurdowska A, et al.: Inhibition of GROalpha-induced human endothelial cell proliferation by the alpha-chemokine inhibitor antileukinate. Cytokine 11:231–238, 1999 Google Scholar
Zhang YJ, Rutledge BJ, Rollins BJ: Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis. J Biol Chem 269:15918–15924, 1994 Google Scholar
Gong JH, Clark-Lewis I: Antagonists of monocyte chemoattractant protein I identified by modification of functionally critical NH2-terminal residues. J Exp Med 181:631–640, 1995 Google Scholar
Gong JH, Ratkay LG, Waterfield JD, et al.: An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-1pr mouse model. J Exp Med 186:131–137, 1997 Google Scholar
Gong JH, Uguccioni M, Dewald B, et al.: RANTES and MCP-3 antagonists bind multiple chemokine receptors. J Biol Chem 271:10521–10527, 1996 Google Scholar
Murakami T, Nakajima T, Koyanagi Y, et al.: A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J Exp Med 186:1389–1393, 1997 Google Scholar
Tamamura H, Imai M, Ishihara T, et al.: Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr(5,12),Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection. Bioorg Med Chem 6:1033–1041, 1998 Google Scholar
Crump MP, Gong JH, Loetscher P, et al.: Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J 16:6996–7007, 1997 Google Scholar
Loetscher P, Gong JH, Dewald B, et al.: N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities. J Biol Chem 273:22279–22283, 1998 Google Scholar
Heveker N, Montes M, Germeroth L, et al.: Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides. Curr Biol 8:369–376, 1998 Google Scholar
Mack M, Luckow B, Nelson PJ, et al.: Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: A novel inhibitory mechanism of HIV infectivity. J Exp Med 187:1215–1224, 1998 Google Scholar
Simmons G, Clapham PR, Picard L, et al.: Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 276:276–279, 1997 Google Scholar
Proudfoot AE, Power CA, Hoogewerf AJ, et al.: Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J Biol Chem 271:2599–2603, 1996 Google Scholar
Elsner J, Petering H, Kimmig D, et al.: The CC chemokine receptor antagonist met-RANTES inhibits eosinophil effector functions. Int Arch Allergy Immunol 118:462–465, 1999 Google Scholar
Yang OO, Swanberg SL, Lu Z, et al.: Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4. J Virol 73:4582–4589, 1999 Google Scholar
Chen JD, Bai X, Yang AG, et al.: Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy. Nat Med 3:1110–1116, 1997 Google Scholar
Yang AG, Bai X, Huang XF, et al.: Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection. Proc Natl Acad Sci USA 94:11567–11572, 1997 Google Scholar
White JR, Lee JM, Young PR, et al.: Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 273:10095–10098, 1998 Google Scholar
De Clercq E, Yamamoto N, Pauwels R, et al.: Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event. Proc Natl Acad Sci USA 89:5286–5290, 1992 Google Scholar
Donzella GA, Schols D, Lin SW, et al.: AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat Med 4:72–77, 1998 Google Scholar
Schols D, Struyf S, Van Damme J, et al.: Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J Exp Med 186:1383–1388, 1997 Google Scholar
Labrosse B, Brelot A, Heveker N, et al.: Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100. J Virol 72:6381–6388, 1998 Google Scholar
de Vreese K, Kofler-Mongold V, Leutgeb C, et al.: The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication. J Virol 70:689–696, 1996 Google Scholar
Schols D, Este JA, Cabrera C, et al.: T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use. J Virol 72:4032–4037, 1998 Google Scholar
Este JA, Cabrera C, Blanco J, et al.: Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4 [in process citation]. J Virol 73:5577–5585, 1999 Google Scholar
Ma Q, Jones D, Borghesani PR, et al.: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4-and SDF-1-deficient mice. Proc Natl Acad Sci USA 95:9448–9453, 1998 Google Scholar
Nagasawa T, Hirota S, Tachibana K, et al.: Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382:635–638, 1996 Google Scholar
Salcedo R, Wasserman K, Young HA, et al.: Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha. Am J Pathol 154:1125–1135, 1999 Google Scholar
Hesselgesser J, Ng HP, Liang M, et al.: Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor. J Biol Chem 273:15687–15692, 1998 Google Scholar
Cooke SP, Forrest G, Venables PJ, et al.: The delta32 deletion of CCR5 receptor in rheumatoid arthritis. Arth Rheum 41:1135–1136, 1998 Google Scholar
Altman GB, Altman LC, Luchtel DL, et al.: Release of RANTES from nasal and bronchial epithelial cells. Cell Biol Toxicol 13:205–213, 1997 Google Scholar
Garred P, Madsen HO, Petersen J, et al.: CC chemokine receptor 5 polymorphism in rheumatoid arthritis. J Rheumatol 25:1462–1465, 1998 Google Scholar
Karpus WJ, Lukacs NW, McRae BL, et al.: An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol 155:5003–5010, 1995 Google Scholar
Serody JS, Cook DN, Kirby SL, et al.: Murine T lymphocytes incapable of producing macrophage inhibitory protein-1 are impaired in causing graft-versus-host disease across a class I but not class II major histocompatibility complex barrier. Blood 93:43–50, 1999 Google Scholar
Baba M, Nishimura O, Kanzaki N, et al.: A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci USA 96:5698–5703, 1999 Google Scholar
Whitby D, Boshoff C: Kaposi's sarcoma herpesvirus as a new paradigm for virus-induced oncogenesis. Curr Opin Oncol 10:405–412, 1998 Google Scholar
Verma MJ, Lloyd A, Rager H, et al.: Chemokines in acute anterior uveitis. Curr Eye Res 16:1202–1208, 1997 Google Scholar
Terada N, Maesako K, Hamano N, et al.: RANTES production in nasal epithelial cells and endothelial cells. J Allergy Clin Immunol 98:S230–237, 1996 Google Scholar
Ciomei M, Pastori W, Mariani M, et al.: New sulfonated distamycin A derivatives with bFGF complexing activity. Biochem Pharmacol 47:295–302, 1994 Google Scholar
Sola F, Farao M, Ciomei M, et al.: FCE 27266, a sulfonic distamycin derivative, inhibits experimental and spontaneous lung and liver metastasis. Invasion Metastasis 15:222–231, 1995 Google Scholar
Sola F, Farao M, Pesenti E, et al.: Antitumor activity of FCE 26644 a new growth-factor complexing molecule. Cancer Chemother Pharmacol 36:217–222, 1995 Google Scholar
Clanton DJ, Buckheit RW Jr, Terpening SJ, et al.: Novel sulfonated and phosphonated analogs of distamycin which inhibit the replication of HIV. Antiviral Res 27:335–354, 1995 Google Scholar
Howard OM, Oppenheim JJ, Hollingshead MG, et al.: Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: A candidate for chemotherapeutic and microbicidal application. J Med Chem 41:2184–2193, 1998 Google Scholar
Howard OM, Korte T, Tarasova NI, et al.: Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function. J Leukoc Biol 64:6–13, 1998 Google Scholar
Mosier DE, Picchio GR, Gulizia RJ, et al.: Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants. J Virol 73:3544–3550, 1999 Google Scholar
Howard OM, Shirakawa AK, Turpin JA, et al.: Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function. J Biol Chem 274:16228–16234, 1999 Google Scholar
Manna SK, Samanta S, Samanta AK: Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils. J Immunol 159:5042–5052, 1997 Google Scholar
Thomas AH: Analysis and assay of polyene antifungal antibiotics. A review. Analyst 101:321–340, 1976 Google Scholar
Thomas AH: Suggested mechanisms for the antimycotic activity of the polyene antibiotics and the N-substituted imidazoles. J Antimicrob Chemother 17:269–279, 1986 Google Scholar
Moonis M, Ahmad I, Bachhawat BK: Liposomal hamycin in the control of experimental aspergillosis in mice: effect of phosphatidic acid with and without cholesterol. J Antimicrob Chemother 31:569–579, 1993 Google Scholar
Mehta RT, McQueen TJ, Keyhani A, et al.: Liposomal hamycin: Reduced toxicity and improved antifungal efficacy in vitro and in vivo. J Infect Dis 164:1003–1006, 1991 Google Scholar
Sozzani S, Bonecchi R, D'Amico G, et al.: Old and new chemokines. Pharmacological regulation of chemokine production and receptor expression: Mini-review. J Chemother 10:142–145, 1998 Google Scholar
Rovai LE, Herschman HR, Smith JB: The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia. J Leukocyte Biol 64:494–502, 1998 Google Scholar
Standiford TJ, Kunkel SL, Rolfe MW, et al.: Regulation of human alveolar macrophage-and blood monocyte-derived interleukin-8 by prostaglandin E2 and dexamethasone. Am J Respir Cell Mol Biol 6:75–81, 1992 Google Scholar
Kovacs EJ, Faunce DE, Ramer-Quinn DS, et al.: Estrogen regulation of JE/MCP-1 mRNA expression in fibroblasts. J Leukocyte Biol 59:562–568, 1996 Google Scholar
Slavin J, Unemori E, Hunt TK, et al.: Monocyte chemotactic protein-1 (MCP-1) mRNA is down-regulated in human dermal fibroblasts by dexamethasone: Differential regulation by TGF-beta. Growth Factors 12:151–157, 1995 Google Scholar
Yamada K, Hayashi T, Kuzuya M, et al.: Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human monocytes in response to monocyte chemotactic protein 1. Artery 22:24–35, 1996 Google Scholar
Wang P, Wu P, Anthes JC, et al.: Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood 83:2678–2683, 1994 Google Scholar
Tumpey TM, Cheng H, Yan XT, et al.: Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. J Leukocyte Biol 63:486–492, 1998 Google Scholar
Gerritsma JS, van Kooten C, Gerritsen AF, et al.: Transforming growth factor-beta 1 regulates chemokine and complement production by human proximal tubular epithelial cells. Kidney Int 53:609–616, 1998 Google Scholar
Kucharzik T, Lugering N, Pauels HG, et al.: IL-4, IL-10 and IL-13 down-regulate monocyte-chemoattracting protein-1 (MCP-1) production in activated intestinal epithelial cells. Clin Exp Immunol 111:152–157, 1998 Google Scholar
John M, Au BT, Jose PJ, et al.: Expression and release of interleukin-8 by human airway smooth muscle cells: Inhibition by Th-2 cytokines and corticosteroids. Am J Respir Cell Mol Biol 18:84–90, 1998 Google Scholar
Hedrick JA, Helms A, Vicari A, et al.: Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. Blood 91:4242–4247, 1998 Google Scholar
Ohmori Y, Hamilton TA: The interferon-stimulated response element and a kappa B site mediate synergistic inductionof murine IP-10 gene transcription by IFN-gamma and TNF-alpha. J Immunol 154:5235–5244, 1995 Google Scholar
Whitson RH Jr., Wong WL, Itakura K: Platelet factor 4 selectively inhibits binding of TGF-beta 1 to the type I TGF-beta 1 receptor. J Cell Biochem 47:31–42, 1991 Google Scholar
Szabo C, Scott GS, Virag L, et al.: Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol 125:379–387, 1998 Google Scholar
Verghese MW, Kneisler TB, Boucheron JA: P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells. J Biol Chem 271:15597–15601, 1996 Google Scholar
Grimm MC, Ben-Baruch A, Taub DD, et al.: Opiates transdeactivate chemokine receptors: Delta and mu opiate receptor-mediated heterologous desensitization. J Exp Med 188:317–325, 1998 Google Scholar
Ali H, Richardson RM, Haribabu B, et al.: Chemoattractant receptor cross-desensitization. J Biol Chem 274:6027–6030, 1999 Google Scholar
Au BT, Teixeira MM, Collins PD, et al.: Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: Synergism with prostanoids and salbutamol. Br J Pharmacol 123:1260–1266, 1998 Google Scholar
Su SB, Gao J, Gong W, et al.: T21/DP107, a synthetic leucine zipper-like domain of the HIV-1 envelope gp41, attracts and activates human phagocytes by using G-protein-coupled formyl peptide receptors. J Immunol 162:5924–5930, 1999 Google Scholar
Su SB, Gong WH, Gao JL, et al.: T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor. Blood 93:3885–3892, 1999 Google Scholar
Deng X, Ueda H, Su SB, et al.: A synthetic peptide derived from HIV-1 gp120 down-regulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the seven-transmembrane G protein-coupled receptor FPRL-1/LXAR. Blood 94:1165–1173, 1999 Google Scholar
Su SB, Gong W, Gao JL, et al.: A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. J Exp Med 189:395–402, 1999 Google Scholar
Badolato R, Johnston JA, Wang JM, et al.: Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. J Immunol 155:4004–4010, 1995 Google Scholar