Elevated Concentrations of Serum Relaxin are Associated with Metastatic Disease in Breast Cancer Patients (original) (raw)
References
Bani D:Relaxin:a pleiotropic hormone.Gen Pharmacol 28:13–22,1997 Google Scholar
Min G, Hartzog MG, Jennings RL, Winn RJ, Sherwood OD:Evidence that endogenous relaxin promotes growth of the vagina and uterus during pregnancy in gilts.Endocrinology 138:560–565,1997 Google Scholar
Zhao I, Roche PJ, Gunnersen JM, Hammond VE, Tregear GW, Wintour EM, Beck F:Mice without a functional relaxin gene are unable to deliver milk to their pups. Endocrinology 140:445–453,1999 Google Scholar
Unemori EN, Amento EP:Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal broblasts.J Biol Chem 265:10681–10685,1990 Google Scholar
Garber SL, Mirochnik Y, Brecklin CS, Unemori EN, Singh AK, Slobodskoy L, Grove BH, Anunda JA, Dunea G: Relaxin decreases renal interstitial brosis and slows progression of renal disease.Kidney Int 59:876–882,2001 Google Scholar
Williams EJ, Benyon RC, Trim N, Hadwin R, Grove BH, Arthur MJ, Unemori EN, Iredale JP:Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver brosis.Gut 49:577–583, 2001 Google Scholar
Unemori EN, Lewis M, Constant J, Arnold G, Grove BH, Normand J, Deshpande U, Salles A, Pickford LB, Erikson ME, Hunt TK, Huang X:Relaxin induces vascular endothelial growth factor and angiogenesis selectively at wound sites.Wound Repair Regen 8:361–370,2000 Google Scholar
Unemori EN, Pickford LB, Salles AL, Piercy CE, Grove BH, Eriksom ME, Amento EP:Relaxin induces an extracellular matrix-degrading phenotype in human lung broblasts in vitro and inhibits lung brosis in a murine model in vivo.J Clin Invest 98:2739–2745,1996 Google Scholar
Qin X, Chua PK, Ohira RH, Bryan-Greenwood GD:An autocrine/paracrine role of human decidual relaxin.II. Stromelysin-1 (MMP-3)and tissue inhibitor of matrix met-alloproteinase-1 (TIMP-1).Biol Reprod 56:812–820, 1997 Google Scholar
Kapila S, Xie Y:Targeted induction of collagenase and stromelysin by relaxin in unprimed and beta-estradiolprimed diarthrodial joint brocartilaginous cells but not in synoviocytes.Lab Invest 78:925–938,1998 Google Scholar
Lenhart JA, Ryan PL, Ohleth K, Palmer SS, Bagnell CA: Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig.Endocrinology 122: 3941–3949,2001 Google Scholar
Polette M, Nawrocki B, Gilles C, Sato H, Seiki M, Tournier JM, Birembaut P:MT-MMP expression and localisation in human lung and breast cancers.Virchows Arch 428:29–35, 1996 Google Scholar
Brummer O, Athar S, Riethdorf L, Loning T, Herbst H: Matrix-metalloproteinases 1,2 and 3 and their tissue inhibitors 1 and 2 in benign and malignant breast lesions: an in situ hybridization study.Virchows Arch 435:566–573, 1999 Google Scholar
Balduyck M, Zerimech F, Goyer V, Lemaire R, Hemon B, Grard G, Thiebaut C, Lemaire V, Dacquembronne E, Duhem T:Specific expression of matrix metalloproteinases 1,3,9 and 13 associated with invasiveness of breast cancer cells in vitro.Clin Exp Metastasis 18:171–178,2000 Google Scholar
Ramos DeSimone N, Hahn-Dantona E, Sipley J, Nagase H, Frech DL, Quigley JP:Activation of matrix metalloproteinase 9 (MMP-9)via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion.J Biol Chem 274:13066–13077,1999 Google Scholar
Talvensaari-Mattila A, Pääkkö P, Höyhtyä M, BlancoSequeiros G, Turpeenniemi-Hujanen T:Matrix metalloproteinase-2 immunoreactive protein:a marker of aggressiveness in breast carcinoma.Cancer 83:1153–1162, 1998 Google Scholar
Tashima LS, Mazoujian G, Bryant-Greenwood GD:Human relaxin in normal,benign and neoplastic breast tissue. J Mol Endocrinol 12:351–364,1994 Google Scholar
Binder C, Hagemann Th, Husen B, Schulz M, Einspanier A:Relaxin enhances in vitro invasiveness of breast cancer cell lines by upregulation of matrix metalloproteases.Mol Hum Reprod 8:789–796,2002 Google Scholar
Einspanier A, Nubbemeyer R, Schlote S, Schumacher M, Ivell R, Fuhrmann K, Marten A:Relaxin in the marmoset monkey:secretion pattern in the ovarian cycle and early pregnancy.Biol Reprod 61:512–520,1999. Google Scholar
O'Byrne EM, Flitcraft JF, Sawyer WK, Hochman J, Weiss G, Steinetz BG:Relaxin bioactivity and immunoactivity in human corpora lutea.Endocrinology 102:1641–1644, 1978 Google Scholar
Bell RJ, Eddie LW, Lester AR, Wood EC, Johnston PD, Niall HD:Relaxin in human pregnancy serum measured with an homologous radioimmunoassay.Obstet Gynecol 69:585–589,1987 Google Scholar
Silvertown JD, Geddes BJ, Summerlee AJ:Adenovirusmediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells.Endocrinology 144:3683–3691,2003 Google Scholar
Plunkett ER, Gammal EB:The effect of relaxin upon DMBA-induced mammary cancer in female rats.Br J Cancer 21:592–600,1967 Google Scholar
Sacchi TB, Bani D, Brandi ML, Falchetti A, Bigazzi M: Relaxin influences growth,differentiation and cell-cell adhesion of human breast cancer cells in culture.Int J Cancer 57:129–134,1994 Google Scholar
Bani D, Flagiello D, Poupon MF, Nistri S, Poirson-Bichat F, Bigazzi M, Bani-Sacchi T:Relaxin promotes differentiation of human breast cancer cells MCF-7 transplanted into nude mice.Virchows Arch 435:509–519,1999 Google Scholar
Unemori EN, Erikson ME, Rocco SE, Sutherland KM, Parsell DA, Mak J, Grove BH:Relaxin stimulates expression of vascular endothelial growth factor in human endometrial cells in vitro and is associated with menometrorrhagia in women.Hum Reprod 14:800–806,1999 Google Scholar
Bani D, Failli P, Bello MG, Thiemermann C, Bani-Sacchi T, Bigazzi M, Masini E:Relaxin activates L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture. Hypertension 31:1240–1247,1998 Google Scholar
Dschietzig T, Richter C, Bartsch C, Laule M, Armbruster FP, Baumann G, Stangl K:The pregnancy hormone relaxin is a player in human heart failure.FASEB J 15:2187–2195, 2001 Google Scholar
Borthwick G, Borthwick AC, Grant P, MacLennan AH: Relaxin levels in the human:an indicator of target storage and production sites.In:MacLennan AH, Tregear GW, Bryant-Greenwood G (eds)Progress in Relaxin Research. Singapore, World Scientific Publishing,1994,pp 251–260 Google Scholar
Nardi E, Bigazzi M, Agrimonti F:Relaxin in fribrocystic disease of the mammary gland.In:Bigazzi M, Greenwood FC, Gasparri F (eds)Biology of Relaxin and its Role in the Human.Amsterdam, Excerpta Medica,1983,pp 417–419 Google Scholar
Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ:Activation of orphan receptors by the hormone relaxin.Science 295:671–674,2002 Google Scholar
Stearns V, Yamouchi H, Hayes DF:Circulating tumor markers in breast cancer:accepted utilities and novel prospects.Breast Cancer Res Treat 52:239–259,1998 Google Scholar