Expression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines (original) (raw)

References

  1. Stetler-Stevenson WG, Aznavoorian S and Liotta LA, 1993, Tumor cell interactions with the extracellular matrix during invasion and metastasis. Ann Rev Cell Biol, 9, 541–73.
    Google Scholar
  2. MacDougall JR and Matrisian L, 1995, Contribution of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis. Cancer Metast Rev, 14, 351–62.
    Google Scholar
  3. MacLeod K, Leprince D and Stehelin D, 1992, The _Ets_gene family. Trends Biochem Sci, 17, 251–6.
    Google Scholar
  4. Wasylyk B, Hahn SL and Giovane A, 1993, The Ets family of transcriptional factors. Eur J Biochem, 277, 7–18.
    Google Scholar
  5. Leprince D, Gegonne A, Coll J, _et al._1983, A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature, 306, 395–7.
    Google Scholar
  6. Nunn MF, Seeburg PH, Moscovici C and Duesberg PH, 1983, Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature, 306, 391–5.
    Google Scholar
  7. Karim FD, Urness LD, Thummel CS, _et al._1990, The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Gene Dev, 4, 1451–3.
    Google Scholar
  8. Quinones S, Sans J, Otari Y, Harris EDJ and Kurkinen M, 1989, Transcriptional regulation of human stromelysin. J Biol Chem, 264, 8339–44.
    Google Scholar
  9. Gutman A and Wasylyk B, 1990, The collagenase gene promoter contains a TPA and oncogene-responsive unit emcompassing the PEA3 and AP-1 binding sites. EMBO J, 9, 2241–6.
    Google Scholar
  10. Nerlov C, Rorth P, Blasi F and Johnsen M, 1991, Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell-type specific activity. Oncogene, 6, 1583–92.
    Google Scholar
  11. Gaire M, Zenaida M, McDonnell S, McNeil L, Lovett DH and Matrisian LM, 1994, Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem, 269, 2032–40.
    Google Scholar
  12. Wasylyk C, Gutman A, Nicholson R and Wasylyk B, 1991, The c-_Ets_oncoprotein activates the stromelysin promoter through the same elements as several nonnuclear oncoproteins. EMBO J, 10, 1127–34.
    Google Scholar
  13. Higashino F, Yoshida K, Noumi T, Seiki M and Fujinaga K, 1995, _Ets_-related protein E1A-F can activate three different matrix metalloproteinase gene promoters. Oncogene, 10, 1461–63.
    Google Scholar
  14. Crawford HC and Matrisian LM, 1996, Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells. Enzyme and Proteins, 49, 20–37.
    Google Scholar
  15. Wernert N, Gilles F, Fafeur V, _et al._1994, Stromal expression of c-_Ets_-1 transcription factor correlates with tumor invasion. Cancer Res, 54, 5683–8.
    Google Scholar
  16. Vandenbunder B, Queva C, Desbiens X, Wernert N and Stehelin D, 1994-95, Expression of the transcription factor c-_Ets_-1 correlates with the occurrence of invasive processes during normal and pathological development. Invasion & Metastasis, 14, 198–209.
    Google Scholar
  17. Bolon I, Brambilla E, Vandenbunder B, Robert C, Lantuejoul S and Brambilla C, 1996, Changes in the expression of matrix proteases and of the transcription factor c-_Ets_-1 during progression of precancerous bronchila lesions. Lab Invest, 75, 1–13.
    Google Scholar
  18. Wernert N, Raes MB, Lasalle P, et al. 1992, c-_Ets_-1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans. Am J Pathol, 140, 119–27.
    Google Scholar
  19. Bolon I, Gouyer V, Devouassoux M, _et al._1995, Expression of c-_Ets_-1, collagenase 1, and urokinasetype plasminogen activator genes in human lung carcinomas. Am J Pathol, 147, 1298–309.
    Google Scholar
  20. Polette M and Birembaut P, 1996, Matrix metalloproteinases in breast carcinoma. The Breast Journal, 2, 209–20.
    Google Scholar
  21. Gilles C and Thompson EW, 1996, The epithelial to mesenchymal transition and metastatic progression in carcinoma. The Breast Journal, 2, 83–96.
    Google Scholar
  22. Savagner P, Boyer B, Valles AM, Jouanneau J and Thiery JP, 1994, Modulations of the epithelial phenotype during embryogenesis and cancer progression. In: Dickson R and Lippman M, eds. Mammary Tumorigenesis and Malignant Progression _._Kluwer Academic Publishers, Chapter 12, pp. 229–49.
  23. Guarino M, 1995, Epithelial-to-mesenchymal change of differentiation. From embryogenetic mechanism to pathological patterns. Histol Histopathol, 10, 171–84.
    Google Scholar
  24. Hay ED, 1995, An overview of epithelio-mesenchymal transformation. Acta Anat, 154, 8–20.
    Google Scholar
  25. Sommers CL, Thompson EW, Torri JA, Kemler EP, Gelmann EP and Byers SW, 1991, Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities. Cell Growth and Differentiation, 2, 365–72.
    Google Scholar
  26. Thompson EW, Paik S, Brünner N, _et al._1992, Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J Cell Physiol, 150, 534–44.
    Google Scholar
  27. Azzam HS and Thompson EW, 1992, Collageninduced activation of the Mr 72,000 type IV collagenase in normal and malignant human fibroblastoid cells. Cancer Res, 52, 4540–4.
    Google Scholar
  28. Azzam H, Arrand GA, Lippman ME and Thompson EW, 1993, MMP-2 activation potential associates with metastatic progression in human breast cancer cell lines, and is independent of MMP-2 production. J Natl Cancer Inst, 85, 1758–64.
    Google Scholar
  29. Bae SN, Arand G, Azzam H, et al. 1993, Molecularand cellular analysis of basement membrane invasionby human breast cancer cells in Matrigel-based _in vitro_assays. Breast Cancer Res and Treat, 24, 241–55.
    Google Scholar
  30. Gilles C, Polette M, Piette J, Birembaut P and FoidartJM, 1994, Epithelial to mesenchymal transition inHPV-33-transfected cervical keratinocytes is associatedwith increased invasiveness and expression ofgelatinase A. Int J Cancer, 59, 661–6.
    Google Scholar
  31. Sommers CL, Byers SW, Thompson EW, Torri J and Gelmann EP, 1994, Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat, 31, 325–35.
    Google Scholar
  32. Gilles C, Polette M, Piette J, _et al._1996, High level of MT-MMP expression is associated with invasiveness of cervical cancer cells. Int J Cancer, 65, 209–13.
    Google Scholar
  33. Gilles C, Polette M, Piette J, Thompson EW, Foidart JM and Birembaut P, 1996, Vimentin expression in cervical carcinomas: association with the invasive and the migratory phenotype of tumor cells. J Pathol, 180, 175–80.
    Google Scholar
  34. Pulyaeva H, Bueno J, Polette M, _et al._1997, MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells. Clin Exp Metastasis, 15, 111–20.
    Google Scholar
  35. Gilles C, Polette M, Seiki M, Birembaut P and Thompson EW, Collagen type I-induced MT1-MMP expression and MMP-2 activation: implication in the metastatic progression of breast carcinoma. Lab Invest, in press.
  36. Thompson EW, Nakamura S, Shima TB, _et al._1991, Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness. Cancer Res, 51, 2670–76.
    Google Scholar
  37. Schuh R, Vestweber D, Riede I, _et al._1986, Molecular cloning of the mouse cell adhesion molecule uvomorulin: cDNA contains a B1-related sequence. Proc Natl Acad Sci USA, 83, 1364–68.
    Google Scholar
  38. Sommers C, Walker-Jones D, Heckford SE, et al. 1989, Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells. Cancer Res, 49, 4258–63.
    Google Scholar
  39. Rømer J, Pyke C, Lund LR, et al. 1994, Expression of uPA and its receptor by both neoplastic and stromal cells during xenografts invasion_. Int J Cancer_, 57, 553–60.
    Google Scholar
  40. Goldberg GI, Wilhem SM, Kronberger A, Bauer EA, Grant GA and Eisen AZ, 1986, Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein. J Biol Chem, 261, 6600–5.
    Google Scholar
  41. Wilhelm SM, Collier IE, Kronberger A, _et al._1987, Human skin fibroblast stromelysin: structure, glycolylation, substrate specificity, and differential expression in normal and tumorigenic cells. Proc Natl Acad Sci USA, 84, 6725–9.
    Google Scholar
  42. Holst-Hansen C, Johannessen B, Høyer-Hansen G, Rømer J, Ellis V and Brünner N, 1996, Urokinasetype plasminogen activation in three human breast cancer cell lines correlates with their _in vitro_invasiveness. Clin Exp Metastasis, 14, 297–307.
    Google Scholar
  43. Price JE, Polyzos A, Zhang RD and Daniels LM, 1990, Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res, 50, 717–21.
    Google Scholar
  44. Brünner N, Thompson EW, Spang-Thomsen M, Rygaard J, Danø K and Zwiebel JA, 1992, _Lac_Z transduced human breast cancer xenografts as an in vivo model for the study of invasion and metastasis. Eur J Cancer, 28, 1989–95.
    Google Scholar
  45. Frandsen TL, Boysen BE, Jirus S, _et al._1992, Assays for the study of human cancer cell invasion and metastasis. Fibrinolysis, 6, 71–6.
    Google Scholar
  46. Borchers AH, Powell MB, Fusenig NE and Bowden T, 1994, Paracrine factor and cell-cell contact-mediated induction of protease and c-_Ets_gene expression in malignant keratinocyte/dermal fibroblast cocultures. Exp Cell Res, 213, 143–7.
    Google Scholar
  47. Gilles F, Raes MB, Stehelin D, Vandenbunder B and Fafeur V, 1996, The c-_Ets_-1 proto-oncogene is a new early-response gene differentially regulated by cytokines and growth factors in human fibroblasts. Exp Cell Res, 222, 370–8.
    Google Scholar
  48. Calmels TPG, Mattot V, Wernert N, Vandenbunder B and Stehelin D, 1995, Invasive tumors induce c-_Ets_-1 transcription factor expression in adjacent stroma. Biol Cell, 84, 53–61.
    Google Scholar
  49. Chen JH, Vercamer C, Li Z, Paulin D, Vandenbunder B and Stehelin D, 1996, PEA3 transactivates vimentin promoter in mammary epithelial and tumor cells. Oncogene, 13, 1667–75.
    Google Scholar
  50. Brünner N, Pyke C, Holst Hansen C, Rømer J, Grøndhal-Hansen J and Danø K, 1994, Urokinase plasminogen activator (uPA) and its type 1 inhibitor (PAI-1): regulators of the proteolysis during cancer invasion and prognostic parameters in breast cancer. In: Dickson R and Lippman M, eds. Mammary Tumorigenesis and Malignant Progression _._Kluwer Academic Publishers, Chapter 16, pp. 299–309.
  51. Basset P, Bellocq JP, Wolf C, _et al._1990, A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature, 348, 699–704.
    Google Scholar
  52. Polette M, Clavel C, Cockett M, Girod de Bentzmann S, Murphy G and Birembaut P, 1993, Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology. Invasion Metast, 13, 31–7.
    Google Scholar
  53. Okada A, Bellocq JP, Rouyer N, _et al._1995, Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci USA, 92, 730–4.
    Google Scholar
  54. Kaya M, Yoshida K, Higasahino F, Mitaka T, Ishii S and Fujinaga K, 1996, A single _Ets_-related transcription factor, E1AF, confers invasive phenotype on human cancer cells. Oncogene, 12, 221–7.
    Google Scholar
  55. Wasylyk B, Wasylyk C, Flores P, Begue A, Leprince D and Stehelin D, 1990, The c-_Ets_proto-oncogene encodes transcription factor that cooperate with c-Fos and c-Jun for transcriptional activation. Nature, 346, 191–3.
    Google Scholar
  56. Logan SK, Garabedian MJ, Campbell CE and Werb Z, 1996, Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors. J Biol Chem, 271, 774–82.
    Google Scholar

Download references