Roles of the Transcription Factors Snail and Slug During Mammary Morphogenesis and Breast Carcinoma Progression (original) (raw)
REFERENCES
Smith D, Franco del Amo F, Gridley T. Isolation of Sna, amouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development. Development 1992 Dec;116(4):1033-9. Erratum in: Development 1993 Mar;117(3):precedi 1992. PubMed Google Scholar
Hemavathy K, Ashraf S, Ip Y. Snail/slug family of repressors: slowly going into the fast lane of development and cancer. Genetics 2000;257:1-12. Google Scholar
Nieto MA, Sargent MG, Wilkinson DG, Cooke J. Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science 1994;264:835-9. PubMed Google Scholar
Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002;3:155-66. PubMed Google Scholar
Nibu Y, Zhang H, Bajor E, Barolo S, Small S, Levine M. dCtBP mediates transcriptional repression by Knirps, Kruppel and Snail in the Drosophila embryo. EMBO J. 1998;17:7009-20. PubMed Google Scholar
Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 2001;23:912-23. PubMed Google Scholar
Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nature Rev 2002;2:442-54. Google Scholar
Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2:76-83. PubMed Google Scholar
Batlle E, Sancho E, Franci C, DominguezD, Monfar M, Baulida J, et al. The transcription factor snail is a repressor of Ecadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000;2:84-9. PubMed Google Scholar
Poser I, DominguezD, de Herreros AG, Varnai A, Buettner R, Bosserhoff AK. Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail. J Biol Chem 2001;276:24661-6. PubMed Google Scholar
Yokoyama K, Kamata N, Hayashi E, Hoteiya T, Ueda N, Fujimoto R, et al. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol 2001;37:65-71. PubMed Google Scholar
Jiao W, Miyazaki K, Kitajima Y. Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo. Br J Cancer 2002;86:98-101. PubMed Google Scholar
Hajra KM, Chen DY, Fearon ER. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 2002;62:1613-8. PubMed Google Scholar
Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003;116:499-511. PubMed Google Scholar
Chen S, Itoh T, Wu K, Zhou D, Yang C. Transcriptional regulation of aromatase expression in human breast tissue. J Steroid Biochem Mol Biol 2002;83:93-9. PubMed Google Scholar
Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, et al.MouseSnail family transcription repressors regulate chondrocyte extracellular matrix, type II collagen and aggrecan. J Biol Chem 2003.
Espineda CE, Chang J, Twiss J, Rajasekaran SA, Rajasekaran AK. Repression of Na,K-ATPase ta1-subunit by the transcription factor Snail in carcinoma. Mol Biol Cell 2003.
Ikenouchi J, Matsuda M, Furuse M, Tsukita S. Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci. 2003;116:1959-67. PubMed Google Scholar
Peinado H, Ballestar E, Esteller M, Cano A. Snail mediates Ecadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol 2004;24:306-19. PubMed Google Scholar
Carver EA, Jiang R, Lan Y, Oram KF, Gridley T. The mouse snail gene encodes a key regulator of the epithelialmesenchymal transition. Mol Cell Biol 2001;21:8184-8. PubMed Google Scholar
Jiang R, Lan Y, Norton C, Sundberg J, Gridley T. The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol 1998;198:277-85. PubMed Google Scholar
Savagner P, Karavanova I, Perantoni A, Thiery JP, Yamada KM. Slug mRNA is expressed by specific mesodermal derivatives during rodent organogenesis. Dev Dyn 1998;213:182-7. PubMed Google Scholar
Cheng CW, Wu PE, Yu JC, Huang CS, Yue CT, Wu CW, et al. Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 2001;20:3814-23. PubMed Google Scholar
Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J, et al. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 2002;21:3241-6. PubMed Google Scholar
Kowalski PJ, Rubin MA, Kleer CG. E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res 2003;5:R217-22. Epub 2003 Sep 26. PubMed Google Scholar
Demir A, Groothuis P, Nap A, Punyadeera C, de Goei A, Evers J, et al. Menstrual effluent induces epithelial-mesenchymal transitions in mesothelial cells. Hum Reprod 2004;19:21-9. PubMed Google Scholar
Inoue A, Seidel M, Wu W, Kamizono S, Ferrando A, Bronson R, et al. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiationinduced apoptosis in vivo. Cancer Cell 2002;2:279-88. PubMed Google Scholar
Okubo T, Truong TK, Yu B, Itoh T, Zhao J, Grube B, et al. Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH). Cancer Res 2001;15:1338-46. Google Scholar
Perez-Losada J, Sanchez-Martin M, Perez-Caro M, Perez-Mancera PA, Sanchez-Garcia I. The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene 2003;22:4205-11. PubMed Google Scholar
Perez-Losada J, Sanchez-Martin M, Rodriguez-Garcia A, Sanchez ML, Orfao A, Flores T, et al. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood 2002;100:1274-86. PubMed Google Scholar
Li ML, Aggeler J, Farson DA, Hatier C, Hassell J, Bissell MJ. Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells. Proc Natl Acad Sci U S A 1987;84:136-40. PubMed Google Scholar
Petersen QW, Ronnov-Jessen L, Howlett AR, Bissel M. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Nat Acad Sci U. S. A. 1992;89:9064-8. Google Scholar
Thompson EW, Torri J, Sabol M, Sommers CL, Byers S, Valverius EM, et al. Oncogene-induced basement membrane invasiveness in human mammary epithelial cells. Clin Exp Metastasis 1994;12:181-94. PubMed Google Scholar
Larue LOM, Hirchenhain J, Kemler R. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci U S A 1994;91:8263-7. PubMed Google Scholar
BerxG, Van Roy F. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res 2001;3:289-93. PubMed Google Scholar
Hunt NC, Douglas-Jones AG, Jasani B, Morgan JM, Pignatelli M. Loss of E-cadherin expression associated with lymph node metastases in small breast carcinomas. Virchows Archiv 1997;430:285-9. PubMed Google Scholar
Asgeirsson KS, Jónasson JG, Tryggvadóttir L, Ólafsdóttir K, Sigurgeirsdóttir JR, Ingvarsson S, et al. Altered expression of E-cadherin in breast cancer. patterns, mechanisms and clinical significance. Eur J Cancer 2000;36:1098-106. PubMed Google Scholar
Gupta SK, Douglas-Jones AG, Jasani B, Morgan JM, Pignatelli M, Mansel RE. E-cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast. Virchows Arch 1997;430:23-8. PubMed Google Scholar
Gamallo C, Palacios J, Suarez A, Pizarro A, Navarro P, Quintanilla M, et al. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 1993;142:987-93. PubMed Google Scholar
Parker C, Rampaul RS, Pinder SE, Bell JA, Wencyk PM, Blamey RW, et al. E-cadherin as a prognostic indicator in primary breast cancer. Br J Cancer 2001;85:1958-63. PubMed Google Scholar
Lipponen P, Saarelainen E, Ji H, Aaltomaa S, Syrjanen K. Expression of E-cadherin (E-CD) as related to other prognostic factors and survival in breast cancer. J Pathol 1994;174:101-9. PubMed Google Scholar
Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, et al. Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 1993;53:1696-701. PubMed Google Scholar
Daniel CW, Strickland P, Friedmann Y. Expression and functional role of E-and P-cadherin in mouse mammary ductal morphogenesis and growth. Dev Biol 1995;169:511-9. PubMed Google Scholar
Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. Acausal role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998;392:190-3. PubMed Google Scholar
Reis-Filho JS, Cancela Paredes J, Milanezi F, Schmitt FC. Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast. Cancer 2002;94:2114-5; discussion 5-6. PubMed Google Scholar
Kanai Y, Oda T, Tsuda H, Ochiai A, Hirohashi S.Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast. Jpn J Cancer Res 1994;85:1035-9. PubMed Google Scholar
Huiping C, Sigurgeirsdottir JR, Jonasson JG, Eiriksdottir G, Johannsdottir JT, Egilsson V, et al. Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer. Br J Cancer 1999;81:1103-10. PubMed Google Scholar
Lei H, Sjoberg-Margolin S, Salahshor S, Werelius B, Jandakova E, Hemminki K, et al. CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk. Int J Cancer 2002;98:199-204. PubMed Google Scholar
Berx G, Cleton-Jansen AM, Strumane K, de Leeuw WJ, Nollet F, van Roy F, et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996;13:1919-25. PubMed Google Scholar
Bukholm IK, Nesland JM, Borresen-Dale AL. Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients [see comments]. J Pathol 2000;190:15-9. PubMed Google Scholar
Nas SJ, Herman JG, Gabrielson E, Iversen PW, Parl FF, Davidson NE, et al. Aberrant methylation of the estrogen Roles of Snail Genes During Mammary Morphogenesis and Cancer 193 receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer. Cancer Res 2000;60:4346-8. PubMed Google Scholar
Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, et al. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 1995;55:5195-9. PubMed Google Scholar
Hennig G, Lowrick O, Birchmeier W, Behrens J. Mechanisms identified in the transcriptional control of epithelial gene expression. J Biol Chem 1996;271:595-602. PubMed Google Scholar
Batsche E, Muchardt C, Behrens J, Hurst HC, Cremisi C. RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol Cell Biol 1998;18:3647-58. PubMed Google Scholar
Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994;127:2021-36. PubMed Google Scholar
Hosono S, Gross I, English MA, Hajra KM, Fearon ER, Licht JD. E-cadherin is a WT1 target gene. J Biol Chem 2000;275:10943-53. PubMed Google Scholar
Tan C, Costello P, Sanghera J, Dominguez D, Baulida J, de Herreros AG, et al. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/-human colon carcinoma cells. Oncogene 2001;20:133-40. PubMed Google Scholar
D'Souza B, Taylor-Papadimitriou J. Overexpression of erb-B2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene. Proc Natl Acad Sci USA 1994;91:7202-6. PubMed Google Scholar
Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.Mol Cell 2001;7:1267-78. PubMed Google Scholar
Yokoyama K, Kamata N, Fujimoto R, Tsutsumi S, Tomonari M, Taki M, et al. Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int J Oncol 2003;22:891-8. PubMed Google Scholar
Prall OW RE, Sutherland RL. Estrogen regulation of cell cycle progression in breast cancer cells. J Steroid Biochem Mol Biol 1998;65:169-74. PubMed Google Scholar
Masood S. Immunocytochemical localization of estrogen and progesterone receptors in imprint preparations of breast carcinomas. Cancer Cell 1992;70:2109-14. Google Scholar
Chen S, Zhou D, Yang C, Okubo T, Kinoshita Y, Yu B, et al. Modulation of aromatase expression in human breast tissue. J Steroid Biochem Mol Biol 2001;79:35-40. PubMed Google Scholar
James VH, McNeill JM, Lai LC, Newton CJ, Ghilchik MW, Reed MJ. Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies. Steroids 1987;50: 269-79. PubMed Google Scholar
Chen S, Zhou D, Okubo T, Kao Y, Eng E, Grube B, et al. Prevention and treatment of breast cancer by suppressing aromatase activity and expression. Ann N Y Acad Sci 2002;963:229-38. PubMed Google Scholar
Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 2003;113: 207-19. PubMed Google Scholar
Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183-232. PubMed Google Scholar
Boyer B, Roche S, Denoyelle M, Thiery JP. Src and Ras are involved in separate pathways in epithelial cell scattering. Embo Journal 1997;16:5904-13. PubMed Google Scholar
Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell 2003;4:499-515. PubMed Google Scholar
Schmidt-Ullrich RK, Mikkelsen RB, Dent P, Todd DG, Valerie K, Kavanagh BD, et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent onEGFR tyrosine phosphorylation. Oncogene 1997;15:1191-7. PubMed Google Scholar
Hines SJ, Organ C, Kornstein MJ, Krystal GW. Coexpression of the c-kit and stem cell factor genes in breast carcinomas. Cell Growth Differ 1995;6:769-79. PubMed Google Scholar