Pharmacokinetics and acute toxicology of intraventricular 131I-monoclonal antibody targeting disialoganglioside in non-human primates (original) (raw)

References

  1. Pfeffer MR, Wygoda M, Siegal T: Leptomeningeal metastases treatment results in 98 consecutive patients. Isr J Med Sci 24: 611–618, 1988
    Google Scholar
  2. Packer RJ, Siegel KR, Sutton LN, Litmann P, Bruce DA, Schut L: Leptomeningeal dissemination of primary central nervous system tumors in childhood. Ann Neurol 18: 217–221, 1985
    Google Scholar
  3. Pinkerton CR, Chessells JM: Failed central nervous system prophylaxis in children with lymphoblastic leukemia: Treatment and outcome. Br J Hematol 57: 553–561, 1984
    Google Scholar
  4. Land VJ, Thomas PRM, Boyett JM, Glicksman AS, Culbert S, Castleberry RP, Berry DH, Vats T, Humphrey GB: Comparison of maintenance treatment regimens for first central nervous system relapse in children with acute lymphocytic leukemia. Cancer 56: 81–87, 1985
    Google Scholar
  5. Heideman RL, Packer RJ, Albright LA, Freeman CR, Rorke LB: Tumor of the central nervous system. In: Pizzo PA, Poplack DG (eds) Principles and Practice of Pediatric Oncology. 2nd edition. J.B. Lippincott Co., Philadelphia, 1993
    Google Scholar
  6. Cheung NK, Saarinen UM, Neely JE, Landmeier B, Donovan D, Coccia PF: Monoclonal antibodies to a glycolipid antigen on human neuroblastoma. Can Res 45: 2642–2649, 1985
    Google Scholar
  7. Miraldi FD, Nelson AD, Kraly C, Ellery S, Landmeier B, Coccia PF, Strandjord SE, Cheung NKV: Diagnostic imaging of human neuroblastoma with radiolabeled antibody. Radiology 161: 413–418, 1986
    Google Scholar
  8. Bergman I, Arbit E, Rosenblum M, Larson SM, Heller G, Cheung NK: Treatment of spinal epidural neuroblastoma xenografts in rats using antiGD2 monoclonal antibody 3F8. J Neurooncol 15: 235–242, 1993
    Google Scholar
  9. Berra B, Gaini SM, Riboni L: Correlation between ganglioside distribution and histologic grading of human astrocytomas. Int J Can 36: 363–366, 1985
    Google Scholar
  10. Traylor TD, Hogan EL: Gangliosides of human cerebral astrocytomas. J Neurochem 34: 126–131, 1980
    Google Scholar
  11. Ye JN, Cheung NKV: A novel O-acetylated ganglioside detected by anti-GD2 monoclonal antibodies. Int J Can 50: 197-201, 1992
    Google Scholar
  12. Wikstrand CJ, Fredman P, Svennerholm L, Bigner SH, Vick W, Fuller G, Bigner DD: Expression of gangliosides GM 2 M GD2, GD3, 3-sioLM1 and 3,6-isoLD1 in CNS malignancies as defined by epitope-characterized monoclonal antibodies (Mabs). (Abstract). 9th International Congress on Brain Tumors Research and Therapy 1991
  13. Longee DC, Wilkstrand CT, Mansson JE, He X, Fuller GN, Bigner SH, Fredman P, Svennerholm L, Bigner DD: Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas. Acta Neuropath 82: 45–54, 1991
    Google Scholar
  14. Cheung NK, Lazarus H, Miraldi FD, Abramowsky CR, Kallick S, Saarinen UM, Spitzer T, Strandjord SE, Coccia PF, Berger NA: Ganglioside GD2 specific monoclonal antibody 3F8: A phase I study in patients with neuroblastoma and malignant melanoma. J Clin Oncol 5: 1430–1440, 1987
    Google Scholar
  15. Houghton AN, Chapman PB, Bajorin DF: Antibodies in cancer therapy: Melanoma. In: Devita VT (ed) Biologic Therapy of Cancer. 1st edition. J.B. Lippincott Co., Philadelphia, 1991
    Google Scholar
  16. Handgretinger R, Anderson K, Lang P: A phase I study of human/mouse chimeric antiganglioside GD2 antibody ch14.18 in patients with neuroblastoma. (Abstract). Eur J Can 31A: 261–267, 1995
    Google Scholar
  17. Miraldi F, Nelson AD, Kraly C, Ellery S, Landmeier B, Coccia PF, Strandjord SE, Cheung NKV: Diagnostic imaging of human neuroblastoma with radiolabeled antitumor antibody. (Abstract). Radiology 153: 148, 1984
    Google Scholar
  18. Cheung NK, Yeh SDJ, Gulati S, Kushner BH, Burch L, Larson S: 131I-3F8 targeted radiotherapy of neuroblastoma (NB): A phase I clinical trial. (Abstract). Proc Am Assoc Cancer Res 31: 284, 1990
    Google Scholar
  19. Arbit AE, Cheung NK, Yeh SDJ, Daghighian F, Zhang JJ, Cordon-Cardo C, Canete A, Pentlow K, Finn R, Larson SM: Quantitative studies of monoclonal antibody targeting to disialoganglioside GD2 in human brain tumors. Eur J Nuc Med 22: 419–426, 1995
    Google Scholar
  20. Zalutsky MR, Garg PK, Schuster JM, Garg S, Archer GE, Fuchs HE, Bigner DD: Effective treatment of experimental human neoplastic meningitis (NM) with intrathecal astatine-211 monoclonal antibody (Mab). (Abstract). J Nucl Med 31: 922, 1990
    Google Scholar
  21. Schold SC, Zalutsky MR, Coleman RE, Glantz MJ, Friedman AH, Jaszczak RJ, Bigner SH, Bigner DD: Distribution and dosimetry of 123I labeled monoclonal antibody 81C6 in patients with anaplastic glioma. Invest Radiol 28: 488–496, 1993
    Google Scholar
  22. Mosely RP, Davies AG, Richardson RB, Zalutsky M, Carrell S, Fabre J, Slack N, Bullimore J, Pizer B, Papanastassiou V, Kemshead JT, Coakham HB, Lashford LS: Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis. B J Cancer 62: 637–642, 1990
    Google Scholar
  23. Pizer B, Papanastassiou V, Hancock J, Cassano W, Coakham H, Kemshead J: A pilot study of monoclonal antibody targeted radiotherapy in the treatment of central nervous system leukaemia in children. Br J Haem 77: 466–472, 1991
    Google Scholar
  24. Pizer BL, Papanastassiou V, Mosely R, Tzanis S, Hancock JP, Kemshead JT, Coakham HB: Meningeal leukemia and medulloblastoma: Preliminary experience with intrathecal radioimmunotherapy. Antibody Immunocon Radiopharm 4: 753–761, 1991
    Google Scholar
  25. Kemshead JT, Papanastassiou V, Coakham HB, Pizer BL: Monoclonal antibodies in the treatment of central nervous system malignancies. Eur J Cancer 28: 511–513, 1992
    Google Scholar
  26. Dippold WG, Bernhard H, Meyer zum Buschenfelde KH: Immunological response to intrathecal GD3ganglioside antibody treatment in cerebral fluid melanosis. In: Oettgen HF (ed) Gangliosides and Cancer. VCH Publishers, New York 240, 1990
    Google Scholar
  27. Malkin MG: Phase I study of intraventricular R24 mouse monoclonal antibody in patients with primary or disseminated R24-positive leptomeningeal neoplasms. (in press)
  28. Lammie GA, Cheung NKV, Gerald W, Rosenblum M, Cordon-Cardo C: Ganglioside GD2 expression in the human nervous system and in neuroblastomas–an immunohistochemical study. Int J Oncol 3: 909–915, 1993
    Google Scholar
  29. Cheung NK, Landmeier B, Neely J, Nelson D, Abramowsky C, Ellery S, Adams R, Miraldi FD: Complete tumor ablation with iodine 131I-radiolabeled disialoganglioside GD2 specific monoclonal antibody against human neuroblastoma xenografted in nude mice. J Natl Can Inst 77: 739–745, 1986
    Google Scholar
  30. Loeb WF: In: Loeb WF, Quimbly FW (eds) Clinical Chemistry in Laboratory Animals. Pergamon Press, New York, NY, 1989
    Google Scholar
  31. Foster WG, McMahon A, Younglai EV: Reproductive endocrine effects of chronic lead exposure on the male cynomolgus monkey. Reprod Toxicol 7: 203–209, 1993
    Google Scholar
  32. Cornelius CE: The use of non-human primates in the study of bilirubin metabolism and bile secretions. Am J Primatol 2: 343–354, 1982
    Google Scholar
  33. Strauss LG, Conti PS: The application of PET in clinical oncology. J Nucl Med 32: 623–648, 1991
    Google Scholar
  34. Wagner HN: Clinical PET: Its time has come. J Nucl Med 32: 561–564, 1991
    Google Scholar
  35. Cheung NK, Cheung IY, Canete A, Yeh SJ, Kushner B, Bonilla MA, Heller G, Larson SM: Antibody response to murine anti GD2 monoclonal antibodies: Correlation with patient survival. Can Res 54: 2228–2233, 1994
    Google Scholar
  36. Kun LE, Moulder J: General principles of radiation therapy. In: Pizzo PA, Poplack DG (eds) Principles and Practice of Pediatric Oncology. J.B. Lippincott Co., Philadelphia 291, 1993
    Google Scholar
  37. Humm JL, Cobb LM: Nonuniformity of tumor dose in radioimmunotherapy. J Nucl Med 31: 75–83, 1990
    Google Scholar
  38. Papanastassiou V, Pizer BL, Coakham HB, Bullimore J, Zananiri A, Kemshead JT: Treatment of recurrent and cystic malignant gliomas by a single intracavitary injection of 131Imonoclonal antibody: Feasibility, pharmacokinetics and dosimetry. Br J Can 67: 144–151, 1993
    Google Scholar
  39. O’Donoghue JA, Bardies M, Wheldon TE: Relationships between tumor size and curability for uniformly targeted therapy with beta-emitting radionuclides. J Nucl Med 36: 1902–1909, 1995
    Google Scholar
  40. Humm JL: Dosimetric aspects of radiolabeled antibodies for tumor therapy. J Nucl Med 27: 1490–1497, 1986
    Google Scholar
  41. Vaidynanathan G, Zalutsky MR: Meta-(211-A) astatobenzylguanine synthesis via astatodemetallation and preliminary _in vitro_and _in vivo_evaluation. Bioconjug Chem 3: 499–503, 1992
    Google Scholar
  42. Zalutsky MR, Moseley RP, Coakman HB, Coleman RE, Bigner DD: Pharmacokinetics and tumor localization of 131Ilabeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies. Can Res 49: 2807–2813, 1989
    Google Scholar

Download references