Progesterone receptor variants found in breast cells repress transcription by wild-type receptors (original) (raw)
References
Clarke CL, Sutherland RL: Progestin regulation of cellular proliferation. Endocr Rev 11: 266–302, 1990 Google Scholar
Horwitz KB: The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev 13: 146–163, 1992 Google Scholar
Horwitz KB, McGuire WL, Pearson OH, Segaloff A: Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science 189: 726–727, 1975 Google Scholar
Clark GM, McGuire WL, Hubay CA: Progesterone receptors as a prognstic factor in stage II breast cancer. N Engl J Med 309: 1343–1347, 1983 Google Scholar
Ponglikitmongkol M, Green S, Chambon P: Genomic organization of the human oestrogen receptor gene. EMBO J 7: 3383–3388, 1988 Google Scholar
Fuqua SAW, Fitzgerald SD, Chamness GC, Tandon AK, McDonnell DP, Nawaz Z, O'Malley BW, McGuire WL: Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res 51: 105–109, 1991 Google Scholar
Koehorst SGA, Jacobs HM, Tilanus MGJ, Bowens AGM, Thijssen JHH, Blankenstein MA: Aberrant oestrogen receptor species in human meningioma tissue. J Steroid Biochem Mol Biol 43: 57–61, 1992 Google Scholar
Skipper JK, Young LJ, Bergeron JM, Tetzlaff MT, Osborn CT, Crews D: Identification of an isoform of oestrogen receptor mRNA lacking exon four and present in the brain. Proc Natl Acad Sci USA 90: 7172–7175, 1993 Google Scholar
Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J: Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93: 5925–5930, 1996 Google Scholar
Pfeffer U, Fecarotta E, Vivaldi G: Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res 55: 2158–2165, 1995 Google Scholar
Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS: Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331: 1056–1061, 1994 Google Scholar
Wilson CM, McPhaul MJ: A and B forms of the androgen receptor are present in human genital skin fibroblasts. Proc Natl Acad Sci USA 91: 1234–1238, 1994 Google Scholar
Brown TR, Lubahn DB, Wilson EM, Joseph DR, French FS, Migeon CJ: Deletion of the steroid binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: Evidence for further genetic heterogeneity in this syndrome. Proc Natl Acad Sci USA 85: 8151–8155, 1988 Google Scholar
Toplin ME, Bubley GJ, Shuster TD, Frantz ME, Spooner AE, Ogata GK, Keer HN, Balk SP: Mutation of the androgen receptor gene in metabolic androgen-independent prostate cancer. N Engl J Med 332: 1393–1398, 1995 Google Scholar
Bamberger CM, Bamberger AM, deCastro M, Chrousos GP: Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 95: 2435–2441, 1995 Google Scholar
Ashraf J, Thompson EB: Identification of the activation-labile gene: A single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. Mol Endocrinol 7: 631–642, 1993 Google Scholar
Kastner P, Mark M, Chambon P: Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life? Cell 83: 859–869, 1995 Google Scholar
Sakurai A, Takeda K, Ain K, Ceccarelli P, Nakai A, Seino S, Bell GI, Refetoff S, DeGroot LJ: Generalized resistance to thyroid hormone associated with a mutation in the ligandbinding domain of the human thyroid receptor ?. Proc Natl Acad Sci USA 86: 8977–8981, 1989 Google Scholar
Usala SJ, Tennyon GE, Bole AE, Lash RW, Gesundheit N, Wondisford EE, Accili D, Hauser P, Weintraub BD: A base mutation of the c-erbA??thyroid hormone receptor in a kindred with thyroid hormone resistance. Molecular heterogeneity in two other kindreds. J Clin Invest 85: 93–100, 1990 Google Scholar
Horwitz KB, Alexander PS: In situ photolinked nuclear progesterone receptors of human breast cancer cells: Subunit molecular weights after transformation and translocation. Endocrinology 113: 2195–2201, 1983 Google Scholar
Wei LL, Gonzalez-Aller C, Wood WM, Horwitz KB: 5?-heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated ‘C’-receptor and unique A-receptor messages. Mol Endocrinol 4: 1833–1840, 1990 Google Scholar
Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P: Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9: 1603–1614, 1990 Google Scholar
Spelsberg TC, Halberg F: Circannual rhythms in steroid concentration and nuclear binding in the chick oviduct. Endocrinology 107: 1234–1244, 1980 Google Scholar
Boyd-Leinen PA, Fournier D, Thomas CS: Nonfunctioning progesterone receptors in the developed oviducts from estrogen-withdrawn immature chicks and in aged nonlaying hens. Endocrinology 111: 30–36, 1982 Google Scholar
Kato J, Hirata S, Nozawa A, Mouri N: The ontogeny of gene expression of progestin receptors in the female rat brain. J Steroid Biochem Mol Biol 47: 173–182, 1993 Google Scholar
Sartorius CA, Groshong SD, Miller LA, Powell RP, Tung L, Takimoto GS, Horwitz KB: New T47D breast cancer cell lines for the independent study of progesterone B-and A-receptors: Only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer Res 54: 3868–3877, 1994 Google Scholar
Sartorius CA, Melville MY, Hovland AR, Tung L, Takimoto GS, Horwitz KB: A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. Mol Endocrinol 8: 1347–1360, 1994 Google Scholar
Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP: Human progesterone receptor A form is a cell and promoter specific repressor of human progesterone receptor B function. Mol Endocrinol 7: 1244–1255, 1993 Google Scholar
Sartorius CA, Tung L, Takimoto GS, Horwitz KB: Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem 5: 9262–9266, 1993 Google Scholar
Wei LL, Miner R: Evidence for the existence of a third progesterone receptor protein in human breast cancer cell line T47D. Cancer Res 54: 340–343, 1994 Google Scholar
Graham JD, Yeates C, Balleine RL, Harvey SS, Milliken JS, Bilous AM, Clarke CL: Characterisation of progesterone receptor A and B expression in human breast cancer. Cancer Res 55: 5063–5068, 1995 Google Scholar
Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E: Complete amino acid sequence of the human progesterone receptor deduced from cloned DNA. Biochem Biophys Res Commun 143: 740–748, 1987 Google Scholar
Sun-Yu N, Gunning P, Eddy R, Ponte P, Leavitt J, Shows T, Kedes L: Evolution of the functional human ?-actin gene and its multi-pseudogene family: Conservation of noncoding regions and chromosomal dispersion of pseudogenes. Mol Cell Biol 5: 2720–2732, 1985 Google Scholar
Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503–517, 1975 Google Scholar
Kastner P, Bocquel MT, Turcotte B, Garnier JM, Horwitz KB, Chambon P, Gronemeyer H: Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms. J Biol Chem 265: 12163–12167, 1990 Google Scholar
Lange-Carter CA, Johnson GL: Assay of MEK kinases. Meth Enzymol 255: 290–301, 1995 Google Scholar
Tora L, Mullick A, Metzger D, Ponglikitmongkol M, Park I, Chambon P: The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J 8: 1981–1986, 1989 Google Scholar
Madsen MW, Reiter BE, Lykkesfeldt AE: Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line, MCF-7/TAMR-1 compared to the parental MCF-7 cell line. Mol Cell Endocrinol 109: 197–207, 1995 Google Scholar
Truss M, Beato M: Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev 14: 459–479, 1995 Google Scholar
Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L: Nuclear receptor coactivators and corepressors. Mol Endocrinol 10: 1167–1177, 1996 Google Scholar
Leygue E, Dotzlaw H, Watson PH, Murphy LC: Identification of novel exon-deleted progesterone receptor variant mRNAs in human breast tissue. Biochem Biophys Res Commun 228: 63–68, 1996 Google Scholar
McGuire WL, Clark GM, Dressler LG, Owens MA: Role of steroid hormone receptors as prognostic factors in primary breast cancer. NCI Monogr 1: 19–23, 1986 Google Scholar
Sedlacek SM, Horwitz KB: The role of progestins and progesterone receptors in the treatment of breast cancer. Steroids 44: 467–484, 1984 Google Scholar
Fitzgerald PA: Handbook of Clinical Endocrinology. Prentice Hall, Englewood Cliffs, NJ, 1992 Google Scholar
Horwitz KB: Editorial: When tamoxifen turns bad. Endocrinology 136: 821–823, 1995 Google Scholar