The Peripheral Benzodiazepine Receptors: A Review (original) (raw)
References
Tallman J, Paul S, Skolnick P, Gallager D: Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science 207: 274-281, 1980 Google Scholar
Mohler H, Okada T: Benzodiazepine receptor: demonstration in the central nervous system. Science 198: 849-851, 1977 Google Scholar
Squires RF, Brastrup C: Benzodiazepine receptors in rat brain. Nature 266: 732-734, 1977 Google Scholar
Olsen RW, Tobin AJ: Molecular biology of GABAA receptors. FASEB J 4: 1469-1480, 1990 Google Scholar
Braestrup C, Squires RF: Specific benzodiazepine receptors in rat brain characterized by high-affinity [3H]diazepam binding. Proc Natl Acad Sci USA 74: 3805-3809, 1977 Google Scholar
Papadopoulos V: Peripheral-type benzodiazepine/ diazepam-binding inhibitor: biological role in steroidogenic cell function. Endocr Rev 14: 222-240, 1993 Google Scholar
Langer SZ, Arbilla S: Imidazopyridines as a tool for the characterization of benzodiazepine receptors: a proposal for a pharmacological classification as omega receptor subtypes. Pharmacol Biochem Behav 29: 763-766, 1988 Google Scholar
Taupin V, Toulmond S, Serrano A, Benavides J, Zavala F: Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre-and post-traumatic treatment with Ro5-4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol 42: 177-185, 1993 Google Scholar
Anholt RRH, Pedersen PL, Souza EBD, Snyder SH: The peripheral-type benzodiazepine receptor. J Biol Chem 261: 576-583, 1986 Google Scholar
Basile AS, Klein DC, Skolnick P: Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site. Brain Res 387: 127-135, 1986 Google Scholar
Woods MJ, Williams DC: Multiple forms and locations for the peripheral-type benzodiazepine receptor. Biochem Pharmacol 52: 1805-1814, 1996 Google Scholar
Olson JM, Ciliax BJ, Mancini WR, Young AB: Presence of peripheral-type benzodiazepine binding sites on human erythrocyte membranes. Eur J Pharmacol 152: 47-53, 1988 Google Scholar
Mestre M, Carriot T, Belin C, Uzan A, Renault C, Dubroeucq MC, Gueremy C, Doble A, Le Fur G: Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart. Life Sci 36:391-400, 1985 Google Scholar
Wang JKT, Morgan JI, Spector S: Benzodiazepines that bind at peripheral sites inhibit cell proliferation. Proc Natl Acad Sci USA 81: 753-756, 1984 Google Scholar
Le Fur G, Perrier ML, Vaucher N, Imbault F, Flamier A, Benavides J, Uzan A, Renault C, Dubroeucq MC, Gueremy C: Peripheral benzodiazepine binding sites: effect of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies. Life Sci 32: 1839-1847, 1983a Google Scholar
Le Fur G, Guilloux F, Rufat P, Benavides J, Uzan A, Renault C, Dubroeucq MC, Gueremy C: Peripheral benzodiazepine binding sites: effect of PK11195, 1-(2-chlorophenyl)-N-methyl-(l-methylpropyl)-3-isoquinolinecarboxamide. II. In vivo studies. Life Sci 32: 1849-1856, 1983b Google Scholar
Le Fur G, Vaucher N, Perrier ML, Flamier A, Benavides J, Renault C, Dubroeucq MC, Gueremy C, Uzan A: Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]Ro5-4864 and [3H]PK11195, by thermodynamic studies. Life Sci 33: 449-457, 1983c Google Scholar
Miccoli L, Oudard S, Beurdeley-Thomas A, Dutrillaux B, Poupon MF: Effect of 1-(2-chlorophenyl)-N-methyl-N-(lmethylpropyl)-3-isoquinoline carboxamide (PK11195), a specific ligand of the peripheral benzodiazepine receptor on the lipid fluidity of mitochondria in human glioma cells. Biochem Pharmacol 58: 715-721, 1999 Google Scholar
Awad M, Gavish M: Differential effect of detergents on [3H]Ro5-4864 and [3H]PK11195 binding to peripheraltype benzodiazepine-binding site. Life Sci 43: 167-175, 1988 Google Scholar
Krueger KE: Molecular and functional properties of mitochondrial benzodiazepine receptors. Biochem Biophys Acta 1241: 453-470, 1995 Google Scholar
Gavish M, Katz Y, Bar-Ami S, Weizman R: Biochemical, physiological, and pathological aspects of the peripheral benzodiazepine receptor. J Neurochem 58: 1589-1601, 1992 Google Scholar
Beaumont K, Skowronski R, Vaughn DA, Fanestil DD: Interactions of lipids with peripheral-type benzodiazepine receptors. Biochem Pharmacol 37:1009-1014, 1988 Google Scholar
Havoundjian H, Cohen RM, Paul SM, Skolnick P: Differential sensitivity of 'central' and 'peripheral' type benzodiazepine receptors to phospholipase A2. J Neurochem 46: 804-811, 1986 Google Scholar
Skowronski R, Beaumont K, Fanestil DD: Modification of the peripheral-type benzodiazepine receptor by arachidonate, diethylpyrocarbonate and thiol reagents. Eur J Pharmacol 143: 305-314, 1987 Google Scholar
Lueddens HWM, Skolnick P: 'Peripheral-type' benzodiazepine receptors in the kidney: regulation of radioligand binding by anions and DIDS. Eur J Pharmacol 133: 205-214, 1987 Google Scholar
Hirsch JD, Beyer CF, Malkowitz L, Loullis CC, Blume AJ: Characterization of ligand binding to mitochondrial benzodiazepine receptors. Mol Pharmacol 35: 164-172, 1989 Google Scholar
Bourguignon JJ: Endogenous and synthetic ligands of mitochondrial benzodiazepine receptors: structure-affinity relationships. In: Giesen-Crouse E. (ed). Peripheral Benzodiazepine Receptors. Academic Press, London, 1993, pp 59-85 Google Scholar
Zisterer DM, Williams DC: Peripheral-type benzodiazepine receptors. Gen Pharmacol 29: 305-314, 1997 Google Scholar
Anholt RRH, DeSouza EB, Oster-Granite ML, Snyder SH: Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. J Pharmacol Exp Ther 233: 517-526, 1985 Google Scholar
De Souza EB, Anholt RR, Murphy KM, Snyder SH, Kuhar MJ: Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis. Endocrinology 116: 567-573, 1985 Google Scholar
Drugan RC Peripheral benzodiazepine receptors: molecular pharmacology to possible physiological significance in stress-induced hypertension. Clin Neuropharmacol 19: 475-496, 1996 Google Scholar
Gallager DW, Mallorga P, Oertel W, Henneberry R, Tallman J: [3H]Diazepam binding in mammalian central nervous system: a pharmacological characterization. J Neurosci 1: 218-225, 1981 Google Scholar
Schoemaker H, Morelli M, Deshmukh P, Yamamura HI: [3H]Ro5-4864 benzodiazepine binding in the kainate lesioned striatum and Huntington's diseased basal ganglia. Brain Res 248: 396-401, 1982 Google Scholar
Marangos PJ, Patel J, Boulenger JP, Clarck-Rosenberg R: Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro5-4864. Mol Pharmacol 22: 26-32, 1982 Google Scholar
Garnier M, Boujrad N, Oke BO, Brown AS, Riond J, Ferrara P, Shoyab M, Suarez-Quian CA, Papadopoulos V: Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: action of peripheral-type benzodiazepine receptor and independent mechanisms. Endocrinology 132: 444-458, 1993 Google Scholar
Woods MJ, Zisterer DM, Williams DC: Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver. Biochem Pharmacol 51: 1283-1292, 1996 Google Scholar
Cahard D, Canat X, Carayon P, Roque C, Casellas P, Le Fur G: Subcellular localization of peripheral benzodiazepine receptors on human leucocytes. Lab Invest 70: 23-28, 1994 Google Scholar
Olson JMM, Junck L, Young AB, Penney JB, Mancini WR: Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. Cancer Res 48: 5837-5841, 1988 Google Scholar
Berkovich A, McPhie P, Campagnone M, Guidotti A, Hensley P: A natural processing product of rat diazepam binding inhibitor triakontatetraneuropeptide (diazepam binding inhibitor 17-50) contains an alpha-helix which allows discrimination between benzodiazepine binding site subtypes. Mol Pharmacol 37: 164-172, 1990 Google Scholar
Guidotti A, Toffano G, Costa E: An endogenous protein modulates the affinity ofGABAand benzodiazepine receptors in rat brain. Nature 275: 553-555, 1978 Google Scholar
Ferrero P, Santi MR, Conti-Tronconi B, Costa F, Guidotti A: Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain. Proc Natl Acad Sci USA 83: 827-831, 1986 Google Scholar
Knudsen J, Hojrup P, Hansen HO, Hansen HF, Roepstorff P: Acyl-CoA-binding protein in the rat. Purifi-cation binding characteristics, tissue concentrations and amino acid sequence. Biochem J 262: 513-519, 1989 Google Scholar
Besman M, Yanagibashi K, Lee T, Kawamura M, Hall P, Shively J: Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor. Proc Natl Acad Sci USA 86: 4897-4901, 1989 Google Scholar
Verma A, Snyder SH: Characterization of porphyrin interactions with peripheral type benzodiazepine receptors. Mol Pharmacol 34: 800-805, 1988 Google Scholar
Doble A, Ferris O, Burgevin MC, Menager J, Uzan A, Dubroeucq MC, Renault C, Gueremy C, Le Fur G: Photoaffinity labeling of peripheral-type benzodiazepinebinding sites. Mol Pharmacol 31: 42-49, 1987 Google Scholar
Antkiewicz-Michaluk L, Mukhin AG, Guidotti A, Krueger KE: Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites. J Biol Chem 263: 17317-17321, 1988 Google Scholar
Sprengel R, Werner P, Seeburg PH, Mukhin AG, Santi MR, Grayson DR, Guidotti A, Krueger KE: Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. J Biol Chem 264: 20415-20421, 1989 Google Scholar
Parola AL, Laird HE: The bovine peripheral-type benzodiazepine receptor: a receptor with low affinity for benzodiazepines. Life Sci 48: 757-764, 1990 Google Scholar
Riond J, Vita N, Le Fur G, Ferrara P: Characterization of a peripheral-type benzodiazepine-binding site in the mitochondria of Chinese hamster ovary cells. FEBS Lett 245: 238-244, 1989 Google Scholar
Garnier M, Dimchev AB, Boujrad N, Price JM, Musto NA, Papadopoulos V: In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol Pharmacol 45: 201-211, 1994 Google Scholar
Krueger KE: Molecular and functional properties of mitochondrial benzodiazepine receptors. Biochim Biophys Acta 1241: 453-470, 1995 Google Scholar
Parola AL, Stump DG, Pepperl DJ, Krueger KE, Regan JW, Laird HE: Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. J Biol Chem 266: 14082-14087, 1991 Google Scholar
Riond J, Mattei MG, Kaghad M, Dumont X, Guillemot JC, LeFur G, Caput D, Ferrara P: Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. Eur J Biochem 195: 305-311, 1991 Google Scholar
Baker ME, Fanestil DD: Mammalian peripheral-type benzodiazepine receptor is homologous to CrtK protein of Rhodobacter capsulatus, a photosynthetic bacterium [letter]. Cell 65: 721-722, 1991 Google Scholar
Thomas JW and Tallman JF: Characterization of photoaffinity labeling of benzodiazepine-binding sites. J Biol Chem 256: 9838-9842, 1981 Google Scholar
McEnery MW: The mitochondrial benzodiazepine receptor: evidence for association with the voltage-dependent anion channel (VDAC). J Bioenerg Biomembr 24: 63-69, 1992 Google Scholar
McEnery MW, Snowman AM, Trifiletti RR, Snyder SH: Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 89: 3170-3174, 1992 Google Scholar
Oudard S, Miccoli L, Beurdeley-Thomas A, Dutrillaux B, Poupon MF: Homophilic anchorage of brain-hexokinase to mitochondria-porins revealed by specific-peptide antibody cross recognition. Elect J Oncol 2: 26-48, 1999 Google Scholar
Joseph-Liauzun E, Farges R, Delmas P, Ferrara P, Loison G: The _M_r 18,000 subunit of the peripheral-type benzodiazepine receptor exhibits both benzodiazepine and isoquinoline carboxamide binding sites in the absence of the voltage-dependent anion channel or of the adenine nucleotide carrier. J Biol Chem 272: 28102-28106, 1997 Google Scholar
Blahos J, Whalin MF, Krueger KF: Identification and purification of a 10-kilodalton protein associated with mitochondrial benzodiazepine receptors. J Biol Chem 270: 20285-20291, 1995 Google Scholar
Galiegue S, Jbilo O, Combes T, Bribes E, Carayon P, Le Fur G, Casellas P: Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. J Biol Chem 274: 2938-2952, 1999 Google Scholar
Hirsch JD, Beyer CF, Malkowitz L, loullis CC, Blume AJ: Characterization of ligand binding to mitochondrial benzodiazepine receptors. Mol Pharmacol 34: 164-172, 1988 Google Scholar
Larcher JC, Vayssiere JL, LeMarquer FJ, Cordeau LR, Keane PE, Bachy A, Gros F, Croizat BP: Effects of peripheral benzodiazepines upon O2 consumption of neuroblastoma cells. Eur J Pharmacol 161: 197-202, 1989 Google Scholar
Miccoli L, Poirson-Bichat F, Sureau F, Bras-Gonçalves R, Bourgeois Y, Dutrillaux B, Poupon MF, Oudard S: Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. J Natl Cancer Inst 90: 1400-1406, 1998 Google Scholar
Zisterer DM, Gorman AM, Williams DC, Murphy MP: The effects of the peripheral-type benzodiazepine acceptor ligands Ro5-4864 and PK11195, on mitochondrial respiration. Meth Find Exp Clin Pharmacol 14: 85-90, 1992 Google Scholar
Kinnally K, Zorov D, Antonenko Y, Snyder S, McEnery M, Tedeschi H: Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands. Proc Natl Acad Sci USA 90: 1374-1378, 1993 Google Scholar
Shiraishi T, Black KL, Ikezaki K, Becker DP: Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells. J Neurosci Res 30: 463-474, 1991 Google Scholar
Black KL, Shiraishi T, Ikezaki K, Tabuchi K, Becker DP: Peripheral benzodiazepine stimulates secretion of growth hormone and mitochondrial proliferation in pituitary tumour GH3 cells. Neurol Res 16: 74-80, 1994 Google Scholar
Itzhak Y, Bender AS, Norenberg MD: Effect of hypoosmotic stress on peripheral-type benzodiazepine receptors in cultured astrocytes. Brain Res 644: 221-225, 1994 Google Scholar
Landau M, Weizman A, Zoref-Shani F, Beery E, Wasseman L, Landau O, Gavish M, Brenner S, Nordenberg J: Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells. Biochem Pharmacol 56: 1029-1034, 1998 Google Scholar
Wang JKT, Morgan JI, Spector S: Differentiation of Friend erythroleukemia cells induced by benzodiazepines. Proc Natl Acad Sci USA 81: 3770-3772, 1984 Google Scholar
Matthew E, Laskin JD, Zimmerman EA, Weinstein IB, Hsu KC, Engelhardt DL: Benzodiazepines have highaffinity binding sites and induce melanogenesis in B16/C3 melanoma cells. Proc Natl Acad Sci USA 78: 3935-3939, 1981 Google Scholar
Morgan JI, Johnson MD, Wang JK, Sonnenfeld KH, Spector S: Peripheral-type benzodiazepines influence ornithine decarboxylase levels and neurite outgrowth in PC12 cells. Proc Nafl Acad Sci USA 82: 5223-5226, 1985 Google Scholar
Curran T, Morgan JI: Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science 229: 1265-1268, 1985 Google Scholar
Clarke GD, Ryan PJ: Tranquillizers can block mitogenesis in 3T3 cells and induce differentiation in Friend cells. Nature 287: 160-161, 1980 Google Scholar
Gorman AMC, O'Beirne GB, Regan CM, Williams DC: Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. J Neurochem 53: 849-855, 1989 Google Scholar
Mukhin AG, Zhong P, Krueger KF: Cofractionation of the 17-kD PK14105 binding site protein with solubilized peripheral-type benzodiazepine binding sites. Biochem Pharmacol 40: 983-989, 1990 Google Scholar
Ikezaki K, Black KL: Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine. Cancer Lett 49: 115-120, 1990 Google Scholar
Laird HEd, Gerrish KF, Duerson KC, Putnam CW, Russell DH: Peripheral benzodiazepine binding sites in Nb 2 node lymphoma cells: effects on prolactin-stimulated proliferation and ornithine decarboxylase activity. Eur J Pharmacol 171: 25-35, 1989 Google Scholar
Kelly-Hershkovitz E, Weizman R, Spanier I, Leschiner S, Lahav M, Weisinger G, Gavish M: Effects of peripheraltype benzodiazepine receptor antisense knockout on MA-10 Leydig cell proliferation and steroidogenesis. J Biol Chem 273: 5478-5483, 1998 Google Scholar
Thomas C, MacGill RS, Miller GC, Pardini RS: Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase. Photochem Photobiol 55: 47-53, 1992 Google Scholar
Miccoli L, Beurdeley-Thomas A, De Pinieux G, Sureau F, Oudard S, Dutrillaux B, Poupon MF: Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria. Cancer Res 58: 5777-5786, 1998 Google Scholar
Carayon P, Portier M, Dussossoy D, Bord A, Petitprêtre G, Canat X, LeFur G, Casellas P: Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Blood 87: 3170-3178, 1996 Google Scholar
Saano V: Effects of peripherally acting benzodiazepines on cell growth and differentiation. In: Giesen-Crouse E (ed). Peripheral Benzodiazepine Receptors. Academic Press, London, 1993, pp 111-121 Google Scholar
Cornu P, Benavides J, Scatton B, Hauw JJ, Philippon J: Increase in ω3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. Acta Neurochir 119: 146-152, 1992 Google Scholar
Ferrarese C, Pierpaoli C, Linfante I, Bobo RH, Guthrie B, Kufta C, Duhaney M, Melisi J, Fuiham MJ: Peripheral benzodiazepine receptors and glucose metabolism in human gliomas. J Neuro-Oncol 22: 15-22, 1994 Google Scholar
Miettinen H, Kononen J, Haapasalo H, Helen P, Sallinen P, Harjuntausta T, Helin H, Alho H: Expression of peripheraltype benzodiazepine receptor and diazepam-binding inhibitor in human astrocytomas: relationship to cell proliferation. Cancer Res 55: 2691-2695, 1995 Google Scholar
Katz Y, Eltan A, Amiri Z, Gavish M: Dramatic increase in peripheral benzodiazepine binding sites in human colonic adenocarcinoma as compared to normal colon. Eur J Pharmacol 148: 483-484, 1988 Google Scholar
Alho H, Kolmer M, Harjuntausta T, Helén P: Increased expression of diazepam binding inhibitor in human brain tumors. Cell Growth Differ 6: 309-314, 1995 Google Scholar
Alho H, Varga V, Krueger KE: Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes and C-6 cells: relation to cell growth. Cell Growth Differ 5: 1005-1014, 1994 Google Scholar
Krueger KE, Papadopoulos V: Mitochondrial benzodiazepine receptors and the regulation of steroid biosynthesis. Annu Rev Pharmacol Toxicol 31: 211-237, 1992 Google Scholar
Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K: Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 62: 21-28, 1997 Google Scholar
Hardwick M, Fertikh D, Culty M, Li H, Vidic B, Papadopoulos V: Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression nuclear localization and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res 59: 831-842, 1999 Google Scholar
Simpson ER, Waterman MR: Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol 50: 427-440, 1988 Google Scholar
Krueger KE: Peripheral-type benzodiazepine receptors: a second site of action for benzodiazepines. Neuropsychopharmacology 4: 237-244, 1991 Google Scholar
Papadopoulos V: Structure and function of the peripheraltype benzodiazepine receptor in steroidogenic cells. Proc Soc Exp Biol Med 217: 130-142, 1998 Google Scholar
Bernassau JM, Reversat JL, Ferrara P, Caput D, Lefur G: A 3D model of peperipheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport. J Mol Graph 11: 236-244, 1993 Google Scholar
Guidotti A, Forchetti CM, Corda MG, Kondel D, Bennett CD, Costa E: Isolation characterization and purifi-cation to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proc Natl Acad Sci USA 80: 3531-3535, 1983 Google Scholar
Yanagibashi K, Ohno Y, Kawamura M, Hall PF: The regulation of intracellular transport of cholesterol in bovine adrenal cells: purification of a novel protein. Endocrinology 123: 2075-2082, 1988 Google Scholar
Mukhin AG, Papadopoulos V, Costa E, Krueger KE: Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc Natl Acad Sci USA 86: 9813-9816, 1989 Google Scholar
Papadopoulos V, Berkovich A, Krueger KE, Costa E, Guidotti A: Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors, Endocrinology 129: 1481-1488, 1991 Google Scholar
Papadopoulos V, Boujrad N, Ikonomovic MD, Ferrara P, Vidic B: Topography of the Leydig cell mitochondrial peripheral-type benzodiazepine receptor. Mol Cell Endocrinol 104: R5-9, 1994 Google Scholar
Fares F, Bar-Ami S, Brandes JM, Gavish M: Changes in the density of peripheral benzodiazepine binding sites in genital organs of the female rat during the oestrous cycle. J Reprod Fert 83: 619-625, 1988 Google Scholar
Weizman A, Amiri Z, Katz Y, Snyder SH, Gavish M: Testosterone prevents castration-induced reduction in peripheral benzodiazepine receptors in Cowper's gland and adrenal. Brain Res 572: 72-75, 1992 Google Scholar
Taketani S, Kohno H, Okuda M, Furukawa T, Tokunaga R: Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis. J Biol Chem 269: 7527-7531, 1994 Google Scholar
Moynagh PN, O'Neill LA, Williams DC: Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells. Biochem Pharmacol 46: 821-827, 1993 Google Scholar
Drugan R: Are the nonmitochondrial peripheral benzodiazepine receptors on leucocytes a novel intermediary of brain behavior and immunity? Lab Invest 70: 1-5, 1994 Google Scholar
Basile AS, Lueddens HW, Skolnick P: Regulation of renal peripheral benzodiazepine receptors by anion transport inhibitors. Life Sci 42: 715-726, 1988 Google Scholar
Romeo E, Auta J, Kozikowski AP, Ma D, Papadopoulos V, Puia G, Costa E, Guidotti A: 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J Pharmacol Exp Ther 262: 971-978, 1992 Google Scholar
Hirsch T: Rôle central de la mitochondrie dans la régulation de l'apoptose. Immunologie. Paris V-René Descartes. Paris, Thése, 1998