Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1 (original) (raw)

References

  1. Lawler JW, Slayter HS, Coligan JE: Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem 253: 8609–8616, 1978
    PubMed Google Scholar
  2. Bornstein P: Thrombospondins: structure and regulation of expression. FASEB J 6: 3290–3299, 1992
    PubMed Google Scholar
  3. Lawler J: The structural and functional properties of thrombospondin. Blood 67: 1197–1209, 1986
    PubMed Google Scholar
  4. Baenziger NL, Brodie GN, Majerus PW: Isolation and properties of a thrombin-sensitive protein of human platelets. J Biol Chem 247: 2723–2731, 1972
    PubMed Google Scholar
  5. Mosher DF, Doyle MJ, Jaffe EA: Synthesis and secretion of thrombospondin by cultured human endothelial cells. J Cell Biol 93: 343–348, 1982
    Article PubMed Google Scholar
  6. Jaffe EA, Ruggiero JT, Leung LLK, Doyle MJ, McKeown-Longo PJ, Mosher DF: Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix. Proc Natl Acad Sci USA 80: 998–1002, 1983
    PubMed Google Scholar
  7. Varani J, Riser BL, Hughes LA, Carey TE, Fligiel SEG, Dixit VM: Characterization of thrombospondin synthesis, secretion and cell surface expression by human tumor cells. Clin Exp Metastasis 7: 265–276, 1989
    PubMed Google Scholar
  8. Mosher DF: Physiology of thrombospondin. Annu Rev Med 41: 85–97, 1990
    PubMed Google Scholar
  9. Lahav J: The functions of thrombospondin and its involvement in physiology and pathophysiology. Biochim Biophys Acta 1182: 1–14, 1993
    PubMed Google Scholar
  10. Roberts DD: Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J 10: 1183–1191, 1996
    PubMed Google Scholar
  11. Tuszynski GP, Gasic TB, Rothman VL, Knudsen KA, Gasic GJ: Thrombospondin, a potentiator of tumor cell metastasis. Cancer Res 47: 4130–4133, 1987
    PubMed Google Scholar
  12. Yabkowitz R, Mansfield PJ, Dixit VM, Suchard SJ: Motility of human carcinoma cells in response to thrombospondin: Relationship to metastatic potential and thrombospondin structural domains. Cancer Res 53: 378–387, 1993
    PubMed Google Scholar
  13. Sheibani N, Frazier WA: Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. Proc Natl Acad Sci USA 92: 6788–6792, 1995
    PubMed Google Scholar
  14. Dameron KM, Volpert OV, Tainsky MA, Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265: 1582–1584, 1994
    PubMed Google Scholar
  15. Weinstat-Saslow DL, Zabrenetzky VS, VanHoutte K, Frazier WA, Roberts DD, Steeg PS: Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res 54: 6504–6511, 1994
    PubMed Google Scholar
  16. Tuzynski GP, Smith M, Rothman VL, Capuzzi DM, Joseph RR, Katz J, Besa EC, Treat J, Switalska HI: Thrombospondin levels in patients with malignancy. Thromb Haemostas 67: 607–611, 1992
    Google Scholar
  17. Nathan FE, Hernandez E, Dunton CJ, Treat J, Switalska HI, Joseph RR, Tuszynski GP: Plasma thrombospondin levels in patients with gynecologic malignancies. Cancer 73: 2853–2858, 1994
    PubMed Google Scholar
  18. Riser BL, Varani J, O'Rourke K, Dixit VM: Thrombospondin binding by human squamous carcinoma and melanoma cells: Relationship to biological activity. Exp Cell Res 174: 319–329, 1998
    Google Scholar
  19. Bertin N, Clezardin P, Kubiak R, Frappart L: Thrombospondin-1 and-2 messenger RNA expression in normal, benign, and neoplastic human breast tissues: Correlation with prognostic factors, tumor angiogenesis, and fibroblastic desmoplasia. Cancer Res 57: 396–399, 1997
    PubMed Google Scholar
  20. Wight TN, Raugi GJ, Mumby SM, Bornstein P: Light microscopic immunolocation of thrombospondin in human tissues. J Hist Cytochem 33: 295–302, 1985
    Google Scholar
  21. Majack RA, Cook SC, Bornstein P: Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells. J Cell Biol 101: 1059–1070, 1985
    PubMed Google Scholar
  22. Majack RA, Mildbrandt J, Dixit VM: Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor. J Biol Chem 262: 8821–8825, 1987
    PubMed Google Scholar
  23. Janat MF, Liau G: Transforming growth factor beta 1 is a powerful modulator of platelet-derived growth factor action in vascular smooth muscle cells. J Cell Physiol 150: 232–242, 1992
    PubMed Google Scholar
  24. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55–63, 1983
    PubMed Google Scholar
  25. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248–254, 1976
    Article PubMed Google Scholar
  26. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685, 1970
    PubMed Google Scholar
  27. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156–159, 1987
    Article PubMed Google Scholar
  28. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, 1989, pp 16.66–16.67
  29. Schreiber E, Matthias P, Muller MM, Schaffner W: Rapid detection of octamer binding proteins with ‘mini-extracts’, prepared from a small number of cells. Nucleic Acids Res 17: 6419, 1989
    PubMed Google Scholar
  30. Vincenti MP, Burrell TA, Taffet SM: Regulation of NF-kB activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester. J Cell Physiol 150: 204–213, 1992
    PubMed Google Scholar
  31. Hayashi K, Kurohiji T, Shirouzu K: Localization of thrombospondin in hepatocellular carcinoma. Hepatology 25: 569–574, 1997
    PubMed Google Scholar
  32. Puisieux A, Galvin K, Troalen F, Bressac B, Marcais C, Galun E, Ponchel F, Yakicier C, Ji J, Ozturk M: Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J 7: 1407–1413, 1993
    PubMed Google Scholar
  33. Yesner LM, Huh HY, Pearce SF, Silverstein RL: Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators. Arterioscler Thromb Vasc Biol 16: 1019–1025, 1996
    PubMed Google Scholar
  34. Touhami M, Fauvel-Lafeve F, Dasilva N, Chomienne C, Legrand C: Induction of thrombospondin-1 by all-trans retinoic acid modulates growth and differentiation of HL-60 myeloid leukemia cell. Leukemia 11: 2137–2142, 1997
    PubMed Google Scholar
  35. Bellon G, Chaqour B, Antonicelli F, Wegrouski J, Claisse D, Haye B, Borel J-P: Differential expression of thrombospondin, collagen, and thyroglobin by thyroid-stimulating hormone and tumor-promoting phorbol ester in cultured porcine thyroid cells. J Cell Physio 160: 75–88, 1994
    Google Scholar
  36. Verani J, Stoolman L. Wang T, Schuger L, Flippen C, Dame M, Johnson KJ, Todd RF 3d, Ryan US, Ward PA: Thrombospondin production and thrombospondin-mediated adhesion in U937 cells. Exp Cell Res 195: 177–182, 1991
    PubMed Google Scholar
  37. Chua CC, Hamdy RC, Chua BHL: Regulation of thrombospondin-1 production by angiotensin II in rat heart endothelial cells. Biochim Biophys Acta 1357: 209–214, 1997
    PubMed Google Scholar
  38. Laherty CD, Gierman TM, Dixit VM: Characterization of the promoter region of the human thrombospondin gene: DNA sequences within the first intron increase transcription. J Biol Chem 264: 11222–11227, 1989
    PubMed Google Scholar
  39. Mettouchi A, Cabon F, Montreau N, Vernier P, Mercier G, Blangy D, Tricoire H, Vigier P, Binetruy B: SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts. EMBO J 13: 5668–5678, 1994
    PubMed Google Scholar
  40. Dejong V, Degeorges A, Filleur S, Ait-Si-Ali S, Mettouchi A, Borstein P, Binetruy B, Cabon F: The Wilm's tumor gene product represses the transcription of thrombospondin 1 in response to overexpression of c-Jun. Oncogene 18: 3143–3151, 1999
    PubMed Google Scholar
  41. Angel P, Karin M: The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim Biophys Acta 1072: 129–157, 1991
    Article PubMed Google Scholar
  42. Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R: Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238: 1386–1392, 1987
    PubMed Google Scholar
  43. Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M: Oncogene jun encodes a sequence-specific _trans_-activator similar to AP-1. Nature 332: 166–171, 1988
    PubMed Google Scholar
  44. Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M: Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370: 226–229, 1994
    PubMed Google Scholar
  45. Bannister AJ, Oehler T, Wilhelm D, Angel P, Kouzarides T: Stimulation of c-Jun activity by CBP: c-Jun residues Ser 63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11: 2509–2514, 1999
    Google Scholar

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