p21-activated kinases in human cancer (original) (raw)

References

  1. Hall A: Rho GTPases and the actin cytoskeleton. Science 279: 509–514, 1998
    Google Scholar
  2. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A: The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70: 401–410, 1992
    Google Scholar
  3. Lauffenburger DA, Horwitz AF: Cell migration: A physically integrated molecular process. Cell 84: 359–369, 1996
    Google Scholar
  4. Kozma R, Ahmed S, Best A, Lim L: The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol Cell Biol 16: 5069–5080, 1996
    Google Scholar
  5. Sells MA, Boyd JT, Chernoff J: p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol 145: 837–849, 1999
    Google Scholar
  6. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L: A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367: 40–46, 1994
    Google Scholar
  7. Bagrodia S, Cerione RA: Pak to the future. Trends Cell Biol 9: 350–355, 1999
    Google Scholar
  8. Jaffer ZM, Chernoff J: p21-activated kinases: Three more join the Pak. Int J Biochem Cell Biol 34: 713–717, 2002
    Google Scholar
  9. Kumar R, Vadlamudi RK: Emerging functions of p21-activated kinases in human cancer cells. J Cell Physiol 193: 133–144, 2002
    Google Scholar
  10. Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R: Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem 273: 28238–28246, 1998
    Google Scholar
  11. Pandey A, Dan I, Kristiansen TZ, Watanabe NM, Voldby J, Kajikawa E, Khosravi F, Blagoev B, Mann M: Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene 21: 3939–3948, 2002
    Google Scholar
  12. Dan C, Nath N, Liberto M, Minden A: PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol Cell Biol 22: 567–577, 2002
    Google Scholar
  13. Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A: PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J 17: 6527–6540, 1998
    Google Scholar
  14. Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP: AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol 16: 85–99, 2002
    Google Scholar
  15. Royal I, Lamarche V, Lamorte L, Kaibuchi K, Park M: Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Mol Biol Cell 11: 1709–1725, 2000
    Google Scholar
  16. He H, Levitzki A, Zhu HJ, Walker F, Burgess A, Maruta H: Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases. J Biol Chem 276: 26741–26744, 2001
    Google Scholar
  17. Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG: Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem 271: 25746–25749, 1996
    Google Scholar
  18. Zhao ZS, Manser E, Loo TH, Lim L: Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol Cell Biol 20: 6354–6363, 2000
    Google Scholar
  19. Papakonstanti EA, Stournaras C: Association of PI-3 Kinase with PAK1 Leads to Actin Phosphorylation and Cytoskeletal Reorganization. Mol Biol Cell 13: 2946–2962, 2002
    Google Scholar
  20. Bokoch GM, Reilly AM, Daniels RH, King CC, Olivera A, Spiegel S, Knaus UG: A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J Biol Chem 273: 8137–8144, 1998
    Google Scholar
  21. King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM: p21-activated kinase (Pak1) is phosphorylated and activated by 3-phosphoinositidedependent kinase-1 (PDK1). J Biol Chem 275: 41201–41209, 2000
    Google Scholar
  22. Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R: Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 4: 681–690, 2002
    Google Scholar
  23. Lian JP, Crossley L, Zhan Q, Huang R, Coffer P, Toker A, Robinson D, Badwey JA: Antagonists of calcium fluxes and calmodulin block activation of the p21-activated protein kinases in neutrophils. J Immunol 166: 2643–2650, 2001
    Google Scholar
  24. Sanders LC, Matsumura F, Bokoch GM, de L: Inhibition of myosin light chain kinase by p21-activated kinase. Science 283: 2083–2085, 1999
    Google Scholar
  25. Chew TL, Masaracchia RA, Goeckeler ZM, Wysolmerski RB: Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK). J Muscle Res Cell Motil 19: 839–854, 1998
    Google Scholar
  26. Zeng Q, Lagunoff D, Masaracchia R, Goeckeler Z, Cote G, Wysolmerski R: Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II. J Cell Sci 113(Pt 3): 471–482, 2000
    Google Scholar
  27. Kiosses WB, Daniels RH, Otey C, Bokoch GM, Schwartz MA: A role for p21-activated kinase in endothelial cell migration. J Cell Biol 147: 831–844, 1999
    Google Scholar
  28. Goeckeler ZM, Masaracchia RA, Zeng Q, Chew TL, Gallagher P, Wysolmerski RB: Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J Biol Chem 275: 18366–18374, 2000
    Google Scholar
  29. Dharmawardhane S, Sanders LC, Martin SS, Daniels RH, Bokoch GM: Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J Cell Biol 138: 1265–1278, 1997
    Google Scholar
  30. Edwards DC, Sanders LC, Bokoch GM, Gill GN: Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics. Nat Cell Biol 1: 253–259, 1999
    Google Scholar
  31. Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, Chernoff J, Hung MC, Kumar R: Regulatable expression of p21-activated kinase-1 promotes anchorageindependent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 275: 36238–36244, 2000
    Google Scholar
  32. Frost JA, KhokhlatchevA, Stippec S, White MA, Cobb MH: Differential effects of PAK1-activating mutations reveal activity-dependent and-independent effects on cytoskeletal regulation. J Biol Chem 273: 28191–28198, 1998
    Google Scholar
  33. Manser E, Huang HY, Loo TH, Chen XQ, Dong JM, Leung T, Lim L: Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 17: 1129–1143, 1997
    Google Scholar
  34. Ohtakara K, Inada H, Goto H, Taki W, Manser E, Lim L, Izawa I, Inagaki M: p21-activated kinase PAK phosphorylates desmin at sites different from those for Rhoassociated kinase. Biochem Biophys Res Commun 272: 712–716, 2000
    Google Scholar
  35. Goto H, Tanabe K, Manser E, Lim L, Yasui Y, Inagaki M: Phosphorylation and reorganization of vimentin by p21-activated kinase (Pak). Genes Cells 7: 91–97, 2002
    Google Scholar
  36. Daub H, Gevaert K, Vandekerckhove J, Sobel A, Hall A: Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16. J Biol Chem 276: 1677–1680, 2001
    Google Scholar
  37. Foster DB, Shen LH, Kelly J, Thibault P, Van E, Mak AS: Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca(2+) sensitivity of smooth muscle contraction. J Biol Chem 275: 1959–1965, 2000
    Google Scholar
  38. Cau J, Faure S, Comps M, Delsert C, Morin N: A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization. J Cell Biol 155: 1029–1042, 2001
    Google Scholar
  39. Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, Bokoch GM: Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem 270: 23934–23936, 1995
    Google Scholar
  40. Frost JA, Xu S, Hutchison MR, Marcus S, Cobb MH: Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol 16: 3707–3713, 1996
    Google Scholar
  41. Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH: Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem 275: 19693–19699, 2000
    Google Scholar
  42. Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH: Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 16: 6426–6438, 1997
    Google Scholar
  43. Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS: Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol 10: 551–554, 2000
    Google Scholar
  44. Chiloeches A, Mason CS, Marais R: S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Mol Cell Biol 21: 2423–2434, 2001
    Google Scholar
  45. Howe AK, Juliano RL: Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol 2: 593–600, 2000
    Google Scholar
  46. Callow MG, Clairvoyant F, Zhu S, Schryver B, Whyte DB, Bischoff JR, Jallal B, Smeal T: Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem 277: 550–558, 2002
    Google Scholar
  47. Sun H, King AJ, Diaz HB, Marshall MS: Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak. Curr Biol 10: 281–284, 2000
    Google Scholar
  48. Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, Reed JC, Bokoch GM: p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 20: 453–461, 2000
    Google Scholar
  49. Widmann C, Gibson S, Johnson GL: Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J Biol Chem 273: 7141–7147, 1998
    Google Scholar
  50. Lee N, MacDonald H, Reinhard C, Halenbeck R, Roulston A, Shi T, Williams LT: Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci USA 94: 13642–13647, 1997
    Google Scholar
  51. Jakobi R, Moertl E, Koeppel MA: p21-activated protein kinase gamma-PAK suppresses programd cell death of BALB3T3 fibroblasts. J Biol Chem 276: 16624–16634, 2001
    Google Scholar
  52. Bagheri Y, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R: Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. J Biol Chem 276: 29403–29409, 2001
    Google Scholar
  53. Ellis LM, Fidler IJ: Angiogenesis and breast cancer metastasis. Lancet 346: 388–390, 1995
    Google Scholar
  54. Fidler IJ: Modulation of the organ microenvironment for treatment of cancer metastasis. J Natl Cancer Inst 87: 1588–1592, 1995
    Google Scholar
  55. Hanahan D, Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353–364, 1996
    Google Scholar
  56. Bagheri Y, Vadlamudi RK, Wang RA, Mendelsohn J, Kumar R: Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis. J Biol Chem 275: 39451–39457, 2000
    Google Scholar
  57. Kiosses WB, Hood J, Yang S, Gerritsen ME, Cheresh DA, Alderson N, Schwartz MA: A dominant-negative p65 PAK peptide inhibits angiogenesis. Circ Res 90: 697–702, 2002
    Google Scholar
  58. Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J: Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 7: 202–210, 1997
    Google Scholar
  59. Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R: Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 275: 12041–12050, 2000
    Google Scholar
  60. Sells MA, Pfaff A, Chernoff J: Temporal and spatial distribution of activated Pak1 in fibroblasts. J Cell Biol 151: 1449–1458, 2000
    Google Scholar
  61. Dharmawardhane S, Brownson D, Lennartz M, Bokoch GM: Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils. J Leukoc Biol 66: 521–527, 1999
    Google Scholar
  62. Dharmawardhane S, Schurmann A, Sells MA, Chernoff J, Schmid SL, Bokoch GM: Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell 11: 3341–3352, 2000
    Google Scholar
  63. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ: Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15: 1796–1807, 2001
    Google Scholar
  64. Xiao GH, Beeser A, Chernoff J, Testa JR: p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem 277: 883–886, 2002
    Google Scholar
  65. Zhang H, Li Z, Viklund EK, Stromblad S: p21-activated kinase 4 interacts with integrin alphavbeta5 and regulates alphavbeta5-mediated cell migration. J Cell Biol 158: 1287–1297, 2002
    Google Scholar
  66. Faure S, Vigneron S, Doree M, Morin N: A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis. EMBO J 16: 5550–5561, 1997
    Google Scholar
  67. Faure S, Vigneron S, Galas S, Brassac T, Delsert C, Morin N: Control of G2/M transition in Xenopus by a member of the p21-activated kinase (PAK) family: A link between protein kinase A and PAK signaling pathways? J Biol Chem 274: 3573–3579, 1999
    Google Scholar
  68. Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Mandal M, Kumar R: p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep 3: 767–773, 2002
    Google Scholar
  69. Thiel D, Reeder M, Pfaff A, Coleman T, Sells M, Chernoff J: Cell Cycle-Regulated Phosphorylation of p21-Activated Kinase 1. Curr Biol 12: 1227, 2002
    Google Scholar
  70. Banerjee M, Worth D, Prowse D, Nikolic M: Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis. Curr Biol 12: 1233, 2002
    Google Scholar
  71. Hofken T, Schiebel E: A role for cell polarity proteins in mitotic exit. EMBO J 21: 4851–4862, 2002
    Google Scholar
  72. Mira JP, Benard V, Groffen J, Sanders LC, Knaus UG: Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci USA 97: 185–189, 2000
    Google Scholar
  73. Salh B, Marotta A, Wagey R, Sayed M, Pelech S: Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer. Int J Cancer 98: 148–154, 2002
    Google Scholar
  74. Renkema GH, Pulkkinen K, Saksela K: Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation. Mol Cell Biol 22: 6719–6725, 2002
    Google Scholar
  75. Roig J, Tuazon PT, Zipfel PA, Pendergast AM, Traugh JA: Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci USA 97: 14346–14351, 2000
    Google Scholar
  76. McManus MJ, Boerner JL, Danielsen AJ, Wang Z, Matsumura F, Maihle NJ: An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex. J Biol Chem 275: 35328–35334, 2000
    Google Scholar
  77. Bekri S, Adelaide J, Merscher S, Grosgeorge J, Caroli B, Perucca L, Kelley PM, Pebusque MJ, Theillet C, Birnbaum D, Gaudray P: Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma. Cytogenet Cell Genet 79: 125–131, 1997
    Google Scholar
  78. Wang RA, Mazumdar A, Vadlamudi RK, Kumar R: P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO J 21: 5437–5447, 2002
    Google Scholar
  79. Yang F, Li X, Sharma M, Zarnegar M, Lim B, Sun Z: Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem 276: 15345–15353, 2001
    Google Scholar

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