Large Numbers of Dysfunctional CD8+ T Lymphocytes Bearing Receptors for a Single Dominant CMV Epitope in the Very Old (original) (raw)
References
Wikby A, Johansson B, Ferguson F, Olsson J: Age-related changes in immune parameters in a very old population of Swedish people: A longitudinal study. Exp Gerontol 29:531–541, 1994 Google Scholar
Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B: Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors. J Gerontol Biol Sci 50(A):B378–B382, 1995 Google Scholar
Wikby A, Johansson B, Olsson J, Löfgren S, Nilsson B-O, Ferguson FG: Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study. Exp Gerontol 37:445–453, 2002 Google Scholar
Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG: Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: The Swedish longitudinal OCTO-immune study. Mech Ageing Dev 102:187–198, 1998 Google Scholar
Olsson J, Wikby A, Johansson B, Löfgren S, Nilsson B-O, Ferguson FG: Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study. Mech Ageing Dev 121:187–201, 2000 Google Scholar
Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham GN: Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin. Immunol. 90:213–219, 1999 Google Scholar
Merino J, Martinez-Gonzalez MA, Rubio M, Inoges S, Sanchez-Ibarrola A, Subira ML: Progressive decrease of CD8high+ CD28+ CD57- cells with ageing. Clin Exp Immunol 112:48–51, 1998 Google Scholar
Fagnoni F, Vescovini R, Mayyola M, Bologna G, Nigro E, Lavgetto G, Franceshi C, Passeri M, Sansoni P: Expansion of cytotoxic CD8+CD28- T cells in healthy aging people, including centenatians. Immunology 88:501–507, 1996 Google Scholar
Wack A, Cossarizza A, Heltai S, Barbieri D, D'Addato S, Fransceschi C, Dellabona P, Casorati G: Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol 10:1281–1288, 1998 Google Scholar
Posnett DN, Edinger JW, Manavalan JS, Irwin C, Marodon G: Differentiation of human CD8 T cells: Implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones. Int Immunol 11:229–241, 1999 Google Scholar
Borysiewicz L, Hickling J, Graham S, Sinclair J, Cranage M, Smith G, Sissons J: Human-specific cytotoxic T cells. Relative frequency of stage-specific CTL recognizing the 72–KD immediate early protein and glycoprotein B expressed by recombinant vaccinia viruses. J Exp Med 168:919–931, 1988 Google Scholar
Gillespie GM, Wills MR, Appay V, O'Callaghan C, Murphy M, Smith N, Sissons P, Rowland-Jones S, Bell JI, Moss PA: Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8+ T lymphocytes in health seropositive donors. J Virol 74:8140–8150, 2000 Google Scholar
Gamadia LE, Rentenaar RJ, Baars PA, Remmerswaal EB, Surachno S, Weel JF, Toebes M, Schumacher TN, ten Berge IJ, van Lier RA: Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. Blood 98:754–761, 2001 Google Scholar
Wills MR, Carmichael AJ, Mynard K, Jin X, Weekes MP, Plachter B, Sissons JG: The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T-cell receptor usage of pp65–specific CTL. J Virol 70(11):7569–7579, 1996 Google Scholar
Solache A, Morgan C, Dodi A, Morte C, Scott I, Baboonian C, Zal B, Goldman J, Grundy J, Madrigal JA: Identification of three HLA-A*0201–restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus. J Immunol 163:5512–5518, 1999 Google Scholar
Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PA: Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 169:1984–1992, 2002 Google Scholar
Gratama JW, Naipal AM, Osterveer MA, Stijnen T, Kluin-Nelemans HC, Ginsel LA, den Ottolander GJ, Heckker AC, Damaro J, van der Giesen M, Tanke HJ: Effects of herpes virus carrier status on peripheral T lymphocyte subsets. Blood 70:516–523, 1987 Google Scholar
Altman J, Moss P, Goulder P, Barouch D, McHeyzer-Williams M, Bell J, McMichael A, Davis M: Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94–96, 1996 Google Scholar
Mayer S, Scheibenbogen C, Lee KH, Keilholz W, Stevanovic S, Rammensee HG, Keilholz U: A sensitive proliferation assay to determine the specific T cell response against HLA-A2.1–binding peptides. J Immunol Methods 197:131–137, 1996 Google Scholar
Callahan JE, Kappler JW, Marrack P: Unexpected expansions of CD8–bearing cells in old mice. J Immunol 151:6657–6669, 1993 Google Scholar
Nilsson B-O, Ernerudh J, Johansson B, Evrin PE, Löfgren S, Ferguson F, Wikby A: Morbidity does not influence the T-cell immune risk phenotype in the elderly: Findings in the Swedish NONA immune study using sample selection protocols. Mech Ageing Dev 124:469–476, 2003 Google Scholar
Weekes MP, Carmichael AJ, Wills MR, Mynard K, Sissons JG: Human CD28-CD8+ T cells contain greatly expanded functional virus-specific memory CTL clones. J Immunol 162:7569–7577, 1999 Google Scholar
Weekes MP, Wills MR, Mynard K, Carmichael AJ, Sissons JG: The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J Virol 73:2099–2108, 1999 Google Scholar
van Baarle D, Hovenkamp E, Callan MF, Wolthers KC, Kostense S, Tan LC, Niesters HG, Osterhaus AD, McMichael AJ, van Oers MH, Miedema F: Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma. Blood 98:146–155, 2001 Google Scholar
Kostense S, Ogg GS, Manting EH, Gillespie G, Joling J, Vandenberghe K, Veenhof E Z, van Baarle D, Jurriaans S, Klein MR, Miedema F: High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: Evidence for impaired CTL effector function. Eur J Immunol 31:677–686, 2001 Google Scholar
Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P, Robbins G, Phillips R, Klenerman P, Walker BD: Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 191:1499–1512, 2000 Google Scholar
Lee PP, Yee C, Savage PA, Fong L, Brockstedt D, Weber JS, Johnson D, Swetter S, Thompson J, Greenberg PD, Roederer M, Davis MM: Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med 5:677–685, 1999 Google Scholar
Franceschi C, Valensin S, Fagnoni F, Barbi C, Bonafe M: Biomarkers of immunosenescence within an evolutionary perspective: The challenge of heterogeneity and the role of antigenic load. Exp Gerontol 34:911–921, 1999 Google Scholar
Hyland P, Barnett C, Pawelec G, Barnett Y: Age-related accumulation of oxidative DNA damage and alterations in levels of p16(INK4a/CDKN2a), p21(WAF1/CIP1/SDI1) and p27(KIP1) in human CD4+ T cell clones in vitro. Mech Ageing Dev 122:1151–1167, 2001 Google Scholar
Spaulding C, Guo W, Effros RB: Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol 34:633–644, 1999 Google Scholar
Brehm MA, Pinto AK, Daniels KA, Schneck JP, Welsh RM, Selin LK: T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Nat Immunol 3: 627–634, 2002 Google Scholar
Hiemstra HS, Schloot NC, van Veelen PA, Willemen SJ, Franken KL, van Rood JJ, de Vries RR, Chaudhuri A, Behan PO, Drijfhout JW, Roep BO: Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Proc Natl Acad Sci USA 98:3988–3991, 2001 Google Scholar
Klenerman P, Zinkernagel RM: Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature 394:482–485, 1998 Google Scholar
McLeod JD: Apoptotic capability in ageing T cells. Mech Ageing Dev 121:151–159, 2000 Google Scholar
Effros RB, Boucher N, Porter V, Zhu X, Spaulding C, Walford RL, Kronenberg M, Cohen D, Schachter F: Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29:601–609, 1994 Google Scholar
Nociari MM, Telford W, Russo C: Postthymic development of CD28-CD8+ T cell subset: Age-associated expansion and shift from memory to naive phenotype. J Immunol 162:3327–3335, 1999 Google Scholar
Pawelec G, Hirokawa K, Fülöp T: Altered T cell signalling in ageing. Mech Ageing Dev 122:1613–1637, 2001 Google Scholar
Tortorella C, Loria MP, Piazzolla G, Schulzekoops H, Lipsky PE, Jirillo E, Antonaci S: Age-related impairment of T cell proliferative responses related to the decline of CD28+ T cell subsets. Arch. Gerontol. Geriatr 26:55–70, 1997 Google Scholar
Pawelec G: Hypothesis: Loss of telomerase inducibility and subsequent replicative senescence in cultured human T cells is a result of altered costimulation. Mech Ageing Dev 121:181–185, 2000 Google Scholar
Effros RB: Costimulatory mechanisms in the elderly. Vaccine 18:1661–1665, 2000 Google Scholar
Weng NP, Levine BL, June CH, Hodes RJ: Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 183:2471–2479, 1996 Google Scholar
Aubert G, Hassan-Walker AF, Madrigal JA, Emery VC, Morte C, Grace S, Koh MB, Potter M, Prentice HG, Dodi IA, Travers PJ: Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants. J Infect Dis 184:955–963, 2001 Google Scholar
Franceschi C, Bonafe M, Valensin S: Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18:1717–1720, 2000 Google Scholar
Ouyang Q, Wagner WM, Walter S, Müller CA, Wikby A, Aubert G, Klatt T, Stevanovic S, Dodi T, Pawelec G: An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech Ageing Dev 124:477–485, 2003 Google Scholar
Zhou T, Edwards CK, Mountz JD: Prevention of age-related T cell apoptosis defect in CD2–fas-transgenic mice. J Exp Med 182:129–137, 1995 Google Scholar