MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis (original) (raw)

References

  1. Rouse, J. et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins . Cell 78, 1027–1037 (1994).
    Article CAS PubMed Google Scholar
  2. Freshney, N. W. et al. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78, 1039–1049 (1994).
    Article CAS PubMed Google Scholar
  3. Han, J., Lee, J. D., Bibbs, L. & Ulevitch, R. J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808–811 ( 1994).
    Article CAS PubMed Google Scholar
  4. Raingeaud, J., Whitmarsh, A. J., Barrett, T., Derijard, B. & Davis, R. J. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16, 1247– 1255 (1996).
    Article CAS PubMed PubMed Central Google Scholar
  5. Wang, X. et al. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J. Biol. Chem. 273, 9373 –9377 (1998).
    Article CAS PubMed Google Scholar
  6. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. & Greenberg, M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326–1331 (1995).
    Article CAS PubMed Google Scholar
  7. Takenaka, K., Moriguchi, T. & Nishida, E. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest. Science 280 , 599–602 (1998).
    Article CAS PubMed Google Scholar
  8. Lee, J.C. et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739– 746 (1994).
    Article CAS PubMed Google Scholar
  9. Simon, C., Goepfert, H. & Boyd, D. Inhibition of the p38 mitogen-activated protein kinase by SB203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion. Cancer Res. 58, 1135– 1139 (1998).
    CAS PubMed Google Scholar
  10. Lee, J.C. et al. Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann. N.Y. Acad. Sci. 696, 149 –170 (1993).
    Article CAS PubMed Google Scholar
  11. Rincon, M. et al. The JNK pathway regulates the in vivo deletion of immature CD4(+)CD8(+) thymocytes. J. Exp. Med. 188, 1817–3011.
  12. Stokoe, D. et al. MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J. 11, 3985– 3994 (1992).
  13. Sithanandam, G. et al. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene. Mol. Cell. Biol. 16, 868–876 (1996).
    Article CAS PubMed PubMed Central Google Scholar
  14. Fukunaga, R. & Hunter, T. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16, 1921 –1933 (1997).
    Article CAS PubMed PubMed Central Google Scholar
  15. Waskiewicz, A. J., Flynn, A., Proud, C. G. & Cooper, J. A. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16, 1909–1920 ( 1997).
    Article CAS PubMed PubMed Central Google Scholar
  16. New, L. et al. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 17, 3372–3384 ( 1998).
    Article Google Scholar
  17. Deak, M., Clifton, A. D., Lucocq, J. M. & Alessi, D. R. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17, 4426–4441 ( 1998).
    Article CAS PubMed PubMed Central Google Scholar
  18. Jiang, Y. et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J. Biol. Chem. 271, 17920–17926 (1996).
    Article CAS PubMed Google Scholar
  19. Wang, X. Z. & Ron, D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272, 1347–1349 ( 1996).
    Article CAS PubMed Google Scholar
  20. Han, J., Jiang, Y., Li, Z., Kravchenko, V. V. & Ulevitch, R. J. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386, 296–299 (1997).
    Article CAS PubMed Google Scholar
  21. Stokoe, D., Engel, K., Campbell, D. G., Cohen, P. & Gaestel, M. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett. 313, 307–313 (1992).
    Article CAS PubMed Google Scholar
  22. Cano, E., Doza, Y. N., Ben-Levy, R., Cohen, P. & Mahadevan, L. C. Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2. Oncogene 12, 805–812 ( 1996).
    Google Scholar
  23. Galanos, C., Freudenberg, M. A. & Reutter, W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc. Natl Acad. Sci. USA 76, 5939–5943 (1979).
    Article CAS PubMed PubMed Central Google Scholar
  24. Jack, R. S. et al. Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. Nature 389 , 742–745 (1997).
    Article CAS PubMed Google Scholar
  25. Rothe, J. et al. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes . Nature 364, 798–802 (1993).
    Article Google Scholar
  26. Marino, M.W. et al. Characterization of tumor necrosis factor-deficient mice. Proc. Natl Acad. Sci. USA 94, 8093– 8098 (1997).
    Article CAS PubMed PubMed Central Google Scholar
  27. Matsumoto, M. et al. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271, 1289– 1291 (1996).
    Article CAS PubMed Google Scholar
  28. Pizzey, J. A., Bennett, F. A. & Jones, G. E. Monensin inhibits initial spreading of cultured human fibroblasts. Nature 305, 315– 317 (1983).
    Article CAS PubMed Google Scholar
  29. Engel, K., Kotlyarov, A. & Gaestel, M. Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. EMBO J. 17, 3363–3371 (1998).
    Article CAS PubMed PubMed Central Google Scholar
  30. Ben-Levy, R., Hooper, S., Wilson, R., Paterson, H. F. & Marshall, C. J. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr. Biol. 8, 1049–1057 (1998).
    Article CAS PubMed Google Scholar
  31. Schultz, H., Engel, K. & Gaestel, M. PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype. J. Cell. Physiol. 173, 310–318 (1997).
    Article CAS PubMed Google Scholar
  32. van Dam, H. et al. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14, 1798–1811 ( 1995).
    Article CAS PubMed PubMed Central Google Scholar
  33. Lalor, P. A., Nelson, G. J. V., Sanderson, R. D. & McHeyzer-Williams, M. G. Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl) acetyl (NP)- specific, IgG + B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur. J. Immunol. 22, 3001–3011 ( 1992).
    Article CAS PubMed Google Scholar

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