Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis (original) (raw)

• Fox, D.A. The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. Arthritis Rheum. 40, 598– 609 (1997).
  Article CAS Google Scholar
• Gregersen, P.K., Silver, J. & Winchester, R.J. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205–1213 (1987).
  Article CAS Google Scholar
• Feldmann, M., Elliott, M.J., Woody, J.N. & Maini, R.N. Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis. Adv. Immunol. 64, 283–350 (1997).
  Article CAS Google Scholar
• Maini, R.N. et al. Monoclonal anti-TNF-α antibody as a probe of pathogenesis and therapy of rheumatoid disease. Immunol. Rev. 144, 195–223 (1995).
  Article CAS Google Scholar
• Moreland, L.W. et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337, 141–147 (1997).
  Article CAS Google Scholar
• Ghivizzani, S.C. et al. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc. Natl. Acad. Sci. USA 95, 4613– 4618 (1998).
  Article CAS Google Scholar
• Otani, K. et al. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J. Immunol. 156, 3558– 3562 (1996).
  CAS PubMed Google Scholar
• Bakker, A.C. et al. Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee. Arthritis Rheum. 40, 893–900 (1997).
  Article CAS Google Scholar
• Zhang, H. et al. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. J. Clin. Invest. 100, 1951–1957 (1997).
  Article CAS Google Scholar
• Apparailly, F. et al. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J. Immunol. 160, 5213–5220 (1998).
  CAS PubMed Google Scholar
• Le, C.H., Nicolson, A.G., Morales, A. & Sewell, K.L. Suppression of collagen-induced arthritis through adenovirus-mediated transfer of a modified tumor necrosis factor α receptor gene. Arthritis Rheum. 40, 1662–1669 (1997).
  Article CAS Google Scholar
• Song, X.Y., Gu, M., Jin, W.W., Klinman, D.M. & Wahl, S.M. Plasmid DNA encoding transforming growth factor-β1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J. Clin. Invest. 101, 2615– 2621 (1998).
  Article CAS Google Scholar
• Firestein, G.S., Yeo, M. & Zvaifler, N.J. Apoptosis in rheumatoid arthritis synovium. J. Clin. Invest. 96, 1631–1638 (1995).
  Article CAS Google Scholar
• Sherr, C.J. & Roberts, J.M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149– 1163 (1995).
  Article CAS Google Scholar
• Hirai, H., Roussel, M.F., Kato, J.Y., Ashmun, R.A. & Sherr, C.J. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15, 2672–2681 (1995).
  Article CAS Google Scholar
• Hall, M., Bates, S. & Peters, G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 11, 1581–1588 (1995).
  CAS PubMed Google Scholar
• Guan, K.L. et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8, 2939–2952 (1994).
  Article CAS Google Scholar
• Lois, A.F., Cooper, L.T., Geng, Y., Nobori, T. & Carson, D.A. Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. Cancer Res. 55, 4010–4013 (1995).
  CAS PubMed Google Scholar
• Alcorta, D.A. et al. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA 93, 13742–13747 (1996).
  Article CAS Google Scholar
• Hannon, G.J. & Beach, D. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371, 257–261 (1994).
  Article CAS Google Scholar
• Zindy, F., Quelle, D.E., Roussel, M.F. & Sherr, C.J. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15, 203–211 (1997).
  Article CAS Google Scholar
• Polyak, K. et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78, 59–66 (1994).
  Article CAS Google Scholar
• Xiong, Y. et al. p21 is a universal inhibitor of cyclin kinases. Nature 366, 701–704 (1993).
  Article CAS Google Scholar
• Reynisdottir, I., Polyak, K., Iavarone, A. & Massague, J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9, 1831–1845 (1995).
  Article CAS Google Scholar
• Zhang, P. et al. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature 387, 151–158 (1997).
  Article CAS Google Scholar
• Terada, Y. et al. Overexpression of cell cycle inhibitors (p16INK4 and p21Cip1) and cyclin D1 using adenovirus vectors regulates proliferation of rat mesangial cells. J. Am. Soc. Nephrol. 8, 51– 60 (1997).
  CAS PubMed Google Scholar
• Sandig, V. et al. Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nature Med. 3, 313–319 (1997).
  Article CAS Google Scholar
• Roessler, B.J., Allen, E.D., Wilson, J.M., Hartman, J.W. & Davidson, B.L. Adenoviral-mediated gene transfer to rabbit synovium in vivo. J. Clin. Invest. 92, 1085–1092 (1993).
  Article CAS Google Scholar
• Kato, D. et al. Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts. FEBS Lett. 427, 203–208 (1998).
  Article CAS Google Scholar
• Uhrbom, L., Nistér, M. & Westermark, B. Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene 15, 505– 514 (1997).
  Article CAS Google Scholar
• Fueyo, J. et al. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 12, 103–110 (1996).
  CAS PubMed Google Scholar
• Kamb, A. et al. A cell cycle regulator potentially involved in genesis of many tumor types . Science 264, 436– 440 (1994).
  Article CAS Google Scholar
• Cairns, P. et al. Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science 265, 415–417 (1994).
  Article CAS Google Scholar
• Nobori, T. et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368, 753–756 (1994).
  Article CAS Google Scholar
• Hara, E. et al. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell. Biol. 16, 859–867 (1996).
  Article CAS Google Scholar
• Wang, X.Q. et al. Accumulation of p16CDKN2A in response to ultraviolet irradiation correlates with late S-G(2)-phase cell cycle delay. Cancer Res. 56, 2510–2514 (1996).
  CAS PubMed Google Scholar
• Robles, S.J. & Adami, G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16, 1113– 1123 (1998).
  Article CAS Google Scholar
• Watanabe, Y., Lee, S.W., Detmar, M., Ajioka, I. & Dvorak, H.F. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 14, 2025–2032 (1997).
  Article CAS Google Scholar
• Mathias, P., Wickham, T., Moore, M. & Nemerow, G. Multiple adenovirus serotypes use α v integrins for infection. J. Virol. 68, 6811–6814 (1994).
  CAS PubMed PubMed Central Google Scholar
• Wickham, T.J., Filardo, E.J., Cheresh, D.A. & Nemerow, G.R. Integrin α v β 5 selectively promotes adenovirus mediated cell membrane permeabilization. J. Cell Biol. 127, 257–264 (1994).
  Article CAS Google Scholar
• Wickham, T.J., Mathias, P., Cheresh, D.A. & Nemerow, G.R. Integrins α v β 3 and alpha v β 5 promote adenovirus internalization but not virus attachment. Cell 73, 309– 319 (1993).
  Article CAS Google Scholar
• Huang, S., Endo, R.I. & Nemerow, G.R. Upregulation of integrins α v β 3 and α v β 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J. Virol. 69, 2257– 2263 (1995).
  CAS PubMed PubMed Central Google Scholar
• Zvaifler, N.J. Fractionated total lymphoid irradiation: a promising new treatment for rheumatoid arthritis? Yes, no, maybe. Arthritis Rheum. 30, 109–114 (1987).
  Article CAS Google Scholar
• Arnett, F.C. et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31, 315–324 (1988).
  Article CAS Google Scholar
• Kanegae, Y. et al. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res. 23, 3816–3821 (1995).
  Article CAS Google Scholar