Metabolic control analysis in biotechnology and medicine (original) (raw)

Nature Biotechnology volume 17, pages 641–643 (1999)Cite this article

Genomics has opened new possibilities for applications in biotechnology and medicine. For these to be realized, one must not forget that most gene products are proteins, most proteins are enzymes, and most enzymes operate as components of metabolism. It is therefore important to put genetic information in the context of what has long been known about how enzymes behave and how they are regulated in metabolism. Without such a framework, there is little chance of predicting the effects of mutations, deletions, or insertions of genes. The relationship between metabolic control and biotechnology was the unifying theme of a recent NATO Advanced Research Workshop at Visegrád, HungaryFootnote 1. As one of the organizers of the meeting, I was struck by the closeness of that relationship, even given my inevitable bias and enthusiasm for the field.

*NATO Advanced Research Workshop held on April 10-16 in Visegraéd, Hungary.

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  1. *NATO Advanced Research Workshop held on April 10-16 in Visegraéd, Hungary.

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  1. director of research at the CNRS Institut Fédératif de Recherche, Biologie Structurale et Microbiologie, Marseilles, France
    Athel Cornish Bowden

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  1. Athel Cornish Bowden
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Bowden, A. Metabolic control analysis in biotechnology and medicine.Nat Biotechnol 17, 641–643 (1999). https://doi.org/10.1038/10854

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