Tumor invasion: molecular shears blunted by green tea (original) (raw)

Nature Medicine volume 5, page 1216 (1999) Cite this article

Abstract

_To the editor_–The recent press, both popular and scientific, has given wide coverage of the beneficial properties of green tea, most commonly used in Asian countries. Consumption has been associated with prevention of cancer development and metastasis1. The main flavonol of green tea, epigallocatechin-3-gallate (EGCG), inhibits urokinase2, one of the hydrolases implicated in tumor invasion. Moreover, green tea consumption by mice significantly limits angiogenesis3, crucial for the growth of all solid tumors.

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Figure 1: a, Zymographic evidence of direct suppression of MMP.

References

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Authors and Affiliations

  1. Institute of Histology and Embryology, Medical School , Padova, 35121, Italy
    Spiridione Garbisa, Nadia Cavallarin & Luigi Sartor
  2. UNIDO-ICS, AREA Science Park, Trieste, 34012, Italy
    Susan Biggin
  3. Tumor Progression Section National Institute for Research on Cancer IST, c/o CBA, Genova, Italy
    Roberto Benelli
  4. Molecular Biology Laboratory National Institute for Research on Cancer IST, c/o CBA, Genova, Italy
    Adriana Albini

Authors

  1. Spiridione Garbisa
  2. Susan Biggin
  3. Nadia Cavallarin
  4. Luigi Sartor
  5. Roberto Benelli
  6. Adriana Albini

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Garbisa, S., Biggin, S., Cavallarin, N. et al. Tumor invasion: molecular shears blunted by green tea.Nat Med 5, 1216 (1999). https://doi.org/10.1038/15145

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