Yeast cell-type regulation of DNA repair (original) (raw)

Nature volume 397, page 310 (1999)Cite this article

Abstract

The mating-type locus (MAT) in the yeast Saccharomyces cerevisiae provides information about whether cells are of the a or α mating type, and genes at this locus encode transcriptional regulators that determine the phenotypes associated with the different cell types1. In a/α diploid cells, the a1/α2 repressor is formed, which inhibits haploid-specific gene expression and indirectly promotes meiosis. Mutations in SIR (silent information regulator) genes cause a loss of both heterochromatin and transcriptional silencing, resulting in the expression of cryptic a and α genes resident at the HML and HMR loci. As a result, sir mutant strains have the properties of a/α diploids.

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Author notes

  1. Stefan U. Åström
    Present address: Umeå Center for Molecular Pathogenesis, Ume University, S-901 87, Umeå, Sweden

Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, 94720, California, USA
    Sara M. Okamura & Jasper Rine

Authors

  1. Stefan U. Åström
  2. Sara M. Okamura
  3. Jasper Rine

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Åström, S., Okamura, S. & Rine, J. Yeast cell-type regulation of DNA repair.Nature 397, 310 (1999). https://doi.org/10.1038/16833

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