Growth-Controlling Action of Human Serum in Cell Culture (original) (raw)

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• Published: 14 November 1959

Nature volume 184, pages 1570–1571 (1959)Cite this article

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Abstract

IT is reasonable to think that there are stimuli and opportunities in every human life which result in a cancerous transformation of some cells. The main factor in the progress of these cells to the clinical tumour stage might be a deficiency in the growth-controlling defensive mechanism. To demonstrate the possible existence of such factors we have studied since 1955 the effect of human serum on different cells in cell culture1.

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References

1. Penttinen, K., and Saxén, E., Ann. Med. Exp. Fenn., 34, 22 (1956); 34, 396 (1956); 35, 335 (1957). Penttinen, K., Saxén, E., Saxén, L., Toivonen, S., and Vainio, T., ibid., 36, 27 (1958).
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2. Vainio, T., and Pentteinen, K., ibid., 37, 18 (1959).
3. Cailleau, R., and Kirk, P. L., Texas Rep., 2, 237 (1957). Bolande, R. P., and Todd, E. W., Arch. Path., 66, 720 (1958). Fedoroff, S., J. Lab. Clin. Med., 48, 55 (1956).
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4. Norris, E. R., and Majnarich, J. J., Amer. J. Phsiol., 153, 492 (1948).
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5. Southam, C. M., Moore, A. E., and Rhoads, C. P., Proc. Amer. Ass. Cancer Res., 2, 251 (1957).
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Authors and Affiliations

1. State Serum Institute, Helsinki
   KARI PENTTINEN & ERKKI SAXÉN

Authors

1. KARI PENTTINEN
2. ERKKI SAXÉN

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PENTTINEN, K., SAXÉN, E. Growth-Controlling Action of Human Serum in Cell Culture.Nature 184, 1570–1571 (1959). https://doi.org/10.1038/1841570b0

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• Issue date: 14 November 1959
• DOI: https://doi.org/10.1038/1841570b0

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