Exposing the human nude phenotype (original) (raw)
- Scientific Correspondence
- Published: 08 April 1999
- Claudio Pignata2,
- Andrei A. Panteleyev1,
- David M. Prowse3,
- Howard Baden3,
- Lorin Weiner3,
- Lucia Gaetaniello2,
- Wasim Ahmad1,
- Nicola Pozzi2,
- Peter B. Cserhalmi-Friedman1,
- Vincent M. Aita4,
- Hendrik Uyttendaele1,
- Derek Gordon5,
- Jurg Ott5,
- Janice L. Brissette3 &
- …
- Angela M. Christiano1,4
Nature volume 398, pages 473–474 (1999)Cite this article
- 972 Accesses
- 206 Citations
- 6 Altmetric
- Metrics details
Abstract
The recent discovery of the human counterpart of the hairless mouse phenotype1 has helped our understanding of the molecular genetics of hair growth. But there are no reports of a defect in the human homologue of the best known of the ‘bald’ mouse phenotypes, the nude mouse2. This may be because affected individuals are so gravely ill from the accompanying immunodeficiency that their baldness goes unnoticed. We have carried out a genetic analysis that reveals a human homologue of the nude mouse.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Figure 1: Molecular analysis of the human nude phenotype.
References
- Ahmad, W. et al. Science 279, 720–724 (1998).
Google Scholar - Flanagan, S. P. Genet. Res. 8, 295–309 (1966).
Google Scholar - Nehls, M., Pfeifer, D., Schorpp, M., Hedrich, H. & Boehm, T. Nature 372, 103–107 (1994).
Article ADS CAS Google Scholar - Pignata, C. et al. Am. J. Med. Genet. 65, 167–170 (1996).
Google Scholar - Schorpp, M., Hoffmann, M., Dear, T. N. & Boehm, T. Immunogenetics 46, 509–515 (1997).
Google Scholar - Kaufmann, E. & Knöchel, W. Mech. Dev. 57, 3–20 (1996).
Google Scholar - Nehls, M. et al. Science 272, 886–889 (1996).
Google Scholar - Brissette, J. L., Li, J., Kamimura, J., Lee, D. & Dotto, G. P. Genes Dev. 10, 2212–2221 (1996).
Google Scholar - Muller-Hermelink, H. K., Wilisch, A., Schultz, A. & Marx, A. Arch. Histol. Cytol. 60, 9–28 (1997).
Google Scholar - Fischer, A. et al. Annu. Rev. Immunol. 15, 93–124 (1997).
Google Scholar - Köpf-Maier, P. et al. Acta Anat. 139, 178–190 (1990).
Google Scholar
Author information
Authors and Affiliations
- Departments of Dermatology, Columbia University, New York, 10032, New York, USA
Jorge Frank, Andrei A. Panteleyev, Wasim Ahmad, Peter B. Cserhalmi-Friedman, Hendrik Uyttendaele & Angela M. Christiano - Department of Pediatrics, Unit of Immunology, Federico II University, Naples, Italy
Claudio Pignata, Lucia Gaetaniello & Nicola Pozzi - Cutaneous Biology Research Center, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Charlestown, 02129, Massachusetts, USA
David M. Prowse, Howard Baden, Lorin Weiner & Janice L. Brissette - Genetics and Development, Columbia University, New York, 10032, New York, USA
Vincent M. Aita & Angela M. Christiano - Laboratory of Statistical Genetics, The Rockefeller University, New York, 10021, New York, USA
Derek Gordon & Jurg Ott
Authors
- Jorge Frank
You can also search for this author inPubMed Google Scholar - Claudio Pignata
You can also search for this author inPubMed Google Scholar - Andrei A. Panteleyev
You can also search for this author inPubMed Google Scholar - David M. Prowse
You can also search for this author inPubMed Google Scholar - Howard Baden
You can also search for this author inPubMed Google Scholar - Lorin Weiner
You can also search for this author inPubMed Google Scholar - Lucia Gaetaniello
You can also search for this author inPubMed Google Scholar - Wasim Ahmad
You can also search for this author inPubMed Google Scholar - Nicola Pozzi
You can also search for this author inPubMed Google Scholar - Peter B. Cserhalmi-Friedman
You can also search for this author inPubMed Google Scholar - Vincent M. Aita
You can also search for this author inPubMed Google Scholar - Hendrik Uyttendaele
You can also search for this author inPubMed Google Scholar - Derek Gordon
You can also search for this author inPubMed Google Scholar - Jurg Ott
You can also search for this author inPubMed Google Scholar - Janice L. Brissette
You can also search for this author inPubMed Google Scholar - Angela M. Christiano
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Frank, J., Pignata, C., Panteleyev, A. et al. Exposing the human nude phenotype.Nature 398, 473–474 (1999). https://doi.org/10.1038/18997
- Issue Date: 08 April 1999
- DOI: https://doi.org/10.1038/18997
This article is cited by
Eyebrow and Eyelash Alopecia: A Clinical Review
- Betty Nguyen
- Jamie Katy Hu
- Antonella Tosti
American Journal of Clinical Dermatology (2023)
Inborn errors of thymic stromal cell development and function
- Alexandra Y. Kreins
- Stefano Maio
- Fatima Dhalla
Seminars in Immunopathology (2021)
Care of Children with DiGeorge Before and After Cultured Thymus Tissue Implantation
- Stephanie E. Gupton
- Elizabeth A. McCarthy
- M. Louise Markert
Journal of Clinical Immunology (2021)
Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations
- Giuliana Giardino
- Svetlana O. Sharapova
- Claudio Pignata
Journal of Clinical Immunology (2021)
Susceptibility to infection in early life: a growing role for human genetics
- Alessandro Borghesi
- Antonio Marzollo
- Jacques Fellay
Human Genetics (2020)