Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse (original) (raw)

Nature volume 192, pages 766–768 (1961)Cite this article

Abstract

AUTORADIOGRAPHY with thymidine labelled with tritium has proved useful for the study of histogenesis in the mammalian brain1–6. Labelled thymidine injected into animals becomes incorporated almost exclusively into deoxyribonucleic acid of cells preparing to divide and remains in their nuclei as a permanent label; the radioactivity is diluted to half with each cell division7. When the autoradiographic method is applied to tissues of animals killed serially, one can determine the time and place of origin of cells, their route and rate of migration, and their ultimate fate.

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References

  1. Sidman, R. L., Miale, I. L., and Feder, N., Exp. Neur., 1, 322 (1959).
    Article CAS Google Scholar
  2. Sidman, R. L., in The Structure of the Eye, edit. by Smelser, B. K. 487 (Academic Press, New York, 1961).
    Google Scholar
  3. Miale, I. L., and Sidman, R. L., Exp. Neur. (in the press).
  4. DeLong, G. R., and Sidman, R. L., J. Comp. Neur. (submitted for publication).
  5. Uzman, L., J. Comp. Neur., 114, 137 (1960).
    Article CAS Google Scholar
  6. Smart, I., and Leblond, C. P., J. Comp. Neur., 116, 339 (1961).
    Google Scholar
  7. Hughes, W. L., Bond, V. P., Brecher, G., Cronkite, E. P., Painter, R. B., Quastler, H., and Sherman, F. G., Proc. U.S. Nat. Acad. Sci., 44, 476 (1958).
    Article ADS CAS Google Scholar
  8. Tilney, F., Proc. Assoc. Res. Nerv. Ment. Dis., 13, 49 (1934).
    Google Scholar
  9. Sholl, D. A., The Organization of the Cerebral Cortex (Methuen and Co., London, 1956).
    Google Scholar
  10. Hubel, D. H., and Wiesel, T. N., J. Physiol. (in the press).

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Authors and Affiliations

  1. Laboratory of Cellular Neuropathology, Harvard Medical School, Boston, 15, Massachusetts
    J. B. ANGEVINE JUN. & R. L. SIDMAN

Authors

  1. J. B. ANGEVINE JUN.
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  2. R. L. SIDMAN
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ANGEVINE, J., SIDMAN, R. Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse.Nature 192, 766–768 (1961). https://doi.org/10.1038/192766b0

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