Inhibition of Synthesis of RNA in E. coli by the Narcotic Drug Lævorphanol (original) (raw)

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• Published: 25 May 1963

Nature volume 198, pages 794–795 (1963)Cite this article

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Abstract

WE have found that morphine and certain of its analogues inhibit the growth of E. coli. With one of these, læevorphanol, complete inhibition is observed at a concentration of 10−3 M and partial inhibition at 10−4 M. Inhibition of growth is demonstrable in minimal as well as in rich culture media and is completely reversible on removal of the drug.

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Author notes

1. ERIC. J. SIMON: Career Scientist of the Health Research Council of New York City.

Authors and Affiliations

1. Department of Medicine, New York University School of Medicine, New York, 16
   ERIC. J. SIMON
2. Summer Research Institute, Will Rogers Hospital and O'Donnell Memorial Research Laboratories, Saranac Lake, New York
   ERIC. J. SIMON

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SIMON, E. Inhibition of Synthesis of RNA in E. coli by the Narcotic Drug Lævorphanol.Nature 198, 794–795 (1963). https://doi.org/10.1038/198794a0

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• Issue date: 25 May 1963
• DOI: https://doi.org/10.1038/198794a0

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