Antibody Production by Leucocytes in Peripheral Blood (original) (raw)

Nature volume 204, pages 1320–1321 (1964)Cite this article

Abstract

THE immune response to foreign antigens is focused in lymphoid tissue, notably spleen and lymph nodes; cells from these sites manifest the entire spectrum of immunological capabilities. Despite the fact that a considerable proportion of leucocytes in peripheral blood are of lymphoid origin and have been used to transfer hyper-sensitivity states, their role in the production of humoral antibody has been uncertain. It was recently shown by Hullinger and Sorkin1 that circulating leucocytes (buffy coat) from rabbits hyperimmunized with human serum could produce significant amounts of specific antibody. By a quite different means we have obtained direct evidence for the elaboration of specific antibody in vitro by such cells, thus confirming and extending their findings.

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References

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Author notes

  1. MICHAEL T. BERNSTEIN: Sophomore medical student trainee, Johns Hopkins University.
  2. ANNE L. JACKSON: National Institutes of Health post-doctoral trainee.

Authors and Affiliations

  1. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
    MAURICE LANDY, RONALD P. SANDERSON, MICHAEL T. BERNSTEIN & ANNE L. JACKSON

Authors

  1. MAURICE LANDY
  2. RONALD P. SANDERSON
  3. MICHAEL T. BERNSTEIN
  4. ANNE L. JACKSON

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LANDY, M., SANDERSON, R., BERNSTEIN, M. et al. Antibody Production by Leucocytes in Peripheral Blood.Nature 204, 1320–1321 (1964). https://doi.org/10.1038/2041320a0

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