Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes (original) (raw)

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• Published: 01 October 1966

Nature volume 212, page 87 (1966)Cite this article

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Abstract

ALTHOUGH triphenylethylene1,2 and many substituted triphenylethylenes3 are known to be oestrogenic, more complex endocrine activity has been encountered in some of its basic derivatives. A notable example is clomiphene, 1-(_p_-diethylaminoethoxyphenyl)-1,2-diphenyl-2-chloro-ethylene (citrate)4, which has the unexpected property of stimulating ovulation in women with ovulatory failure of certain types5,6.

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References

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Authors and Affiliations

1. Research Department, Imperial Chemical Industries, Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire
   M. J. K. HARPER & A. L. WALPOLE

Authors

1. M. J. K. HARPER
2. A. L. WALPOLE

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HARPER, M., WALPOLE, A. Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes.Nature 212, 87 (1966). https://doi.org/10.1038/212087a0

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• Issue date: 01 October 1966
• DOI: https://doi.org/10.1038/212087a0

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