Antitumour Activity in a Series of bisDiketopiperazines (original) (raw)

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• Published: 26 April 1969

Nature volume 222, pages 384–385 (1969)Cite this article

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Abstract

FURST1 has argued that most drugs which retard the growth of human or experimental neoplasms are actual or potential chelating agents. Although the correlation of the two properties is probably often no more than coincidental, the idea of attempting to influence the growth of cells and tumours with chelating agents has been examined2–5. It is an attractive idea because many enzyme systems depend on or contain trace metals.

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Authors and Affiliations

1. Department of Chemistry, Imperial Cancer Research Fund, London
   A. M. CREIGHTON
2. Department of Cancer Chemotherapy, Imperial Cancer Research Fund, London
   A. M. CREIGHTON, K. HELLMANN & SUSAN WHITECROSS

Authors

1. A. M. CREIGHTON
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2. K. HELLMANN
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3. SUSAN WHITECROSS
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CREIGHTON, A., HELLMANN, K. & WHITECROSS, S. Antitumour Activity in a Series of _bis_Diketopiperazines.Nature 222, 384–385 (1969). https://doi.org/10.1038/222384a0

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• Received: 10 February 1969
• Revised: 20 March 1969
• Issue Date: 26 April 1969
• DOI: https://doi.org/10.1038/222384a0

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