Abortive Transformation by the Tsa Mutant of Polyoma Virus (original) (raw)

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• Published: 26 July 1969

Nature volume 223, pages 397–398 (1969)Cite this article

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Abstract

THE Tsa mutant of polyoma virus (PyTsa) is a conditional lethal mutant isolated by Fried1. PyTsa grows normally at the permissive temperature (31.5° C), but at the non-permissive temperature (38.5° C) there is a failure of normal viral DNA synthesis, and of vegetative growth in mouse cells. Transformation of hamster cells by PyTsa is also inhibited at 38.5° C; this raises the question, Is the mutant gene required simply for the viral induced change in the cell physiology or is it concerned with the stable propagation of the transformed state ? These alternatives can be distinguished by the phenomenon of abortive transformation2.

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References

1. Fried, M., Virology, 25, 669 (1965).
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2. Stoker, M., Nature, 218, 234 (1968).
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3. Stoker, M., O'Neill, C., Berryman, S., and Waxman, V., Int. J. Cancer, 3 683 (1968).
4. Crawford, L. V., Virology, 18 177 (1962).

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Authors and Affiliations

1. Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, WC2
   MICHAEL STOKER
2. The Salk Institute for Biological Studies, La Jolla, California
   RENATO DULBECCO

Authors

1. MICHAEL STOKER
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2. RENATO DULBECCO
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STOKER, M., DULBECCO, R. Abortive Transformation by the Tsa Mutant of Polyoma Virus.Nature 223, 397–398 (1969). https://doi.org/10.1038/223397a0

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• Received: 02 June 1969
• Issue Date: 26 July 1969
• DOI: https://doi.org/10.1038/223397a0

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