Theta Isoantigen as a Marker of Thymus-derived Lymphocytes in Mice (original) (raw)
- Letter
- Published: 25 October 1969
Nature volume 224, pages 378–379 (1969)Cite this article
- 233 Accesses
- 315 Citations
- Metrics details
Abstract
THERE is an obvious need for a marker that will differentiate one type of lymphocyte from another. The need has become urgent in view of recent evidence suggesting that there are at least two populations of lymphocytes, one thymus-derived and one bone marrow-derived, which participate in different ways in the immune response1. The theta (θ) isoantigen (θ is determined by a single locus with two alleles: θAKR found in AKR and RF mice and θC3H present in most other inbred strains of mice tested), described by Reif and Allen2,3, which is found chiefly in thymus lymphocytes and brain, and to a lesser extent in peripheral lymphocytes in mice, seemed a possible antigenic marker of thymus-derived lymphocytes. To establish that θ is such a marker, it is necessary to demonstrate that there is a discrete population of peripheral lymphocytes which carry the antigen and that these cells are thymus-dependent.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Mitchell, G. F., and Miller, J. F. A. P., J. Exp. Med., 128, 821 (1968).
Article CAS Google Scholar - Reif, A. E., and Allen, J. M. V., J. Exp. Med., 120, 413 (1964).
Article CAS Google Scholar - Reif, A. E., and Allen, J. M. V., Nature, 209, 521 (1966).
Article ADS CAS Google Scholar - Wigzell, H., Transplantation, 3, 423 (1965).
Article CAS Google Scholar - Bomford, R., Breitner, J., Mitchison, N. A., Negroni, N., and Raff, M., Fourth Quadrennial Internat. Conf. on Cancer: Immunity and Tolerance as Factors in Oncogenesis, Perugia, 1969 (Instituto di Anatomia e Istologia Patologica, Perugia, in the press).
Google Scholar - Boyse, E. A., Old, L. J., and Chuuroulinkov, I., Methods in Medical Research, 10, 39 (Year Book Medical Publishers, Chicago, 1964).
Google Scholar - Sanderson, A. R., Brit. J. Exp. Path., 45, 398 (1964).
CAS PubMed Google Scholar - Turk, J. L., and Willoughby, D. A., Lancet, i, 249 (1967).
- Taub, R. N., and Lance, E. M., J. Exp. Med., 128, 1281 (1968).
Article CAS Google Scholar - Levey, R. H., and Medawar, P. B., Ann. NY Acad. Sci., 129, 164 (1966).
Article ADS Google Scholar - Parrott, D. M. V., De Sousa, M. A. B., and East, J., J. Exp. Med., 123, 191 (1966).
Article CAS Google Scholar - Pantelouris, E. M., Nature, 217, 370 (1968).
Article ADS CAS Google Scholar - Schlesinger, M., and Yron, I., Science, 164, 1412 (1969).
Article ADS CAS Google Scholar
Author information
Authors and Affiliations
- National Institute for Medical Research, Mill Hill, London, NW7
MARTIN C. RAFF
Authors
- MARTIN C. RAFF
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
RAFF, M. Theta Isoantigen as a Marker of Thymus-derived Lymphocytes in Mice.Nature 224, 378–379 (1969). https://doi.org/10.1038/224378a0
- Received: 07 July 1969
- Revised: 12 August 1969
- Issue Date: 25 October 1969
- DOI: https://doi.org/10.1038/224378a0
This article is cited by
Avrion Mitchison (1928–2022)
- Amanda G. Fisher
- Matthias Merkenschlager
Nature Immunology (2023)
A brief history of T cell help to B cells
- Shane Crotty
Nature Reviews Immunology (2015)
- Shane Crotty
Beyond a pedagogical tool: 30 years of Molecular Biology of the Cell
- Norberto Serpente
Nature Reviews Molecular Cell Biology (2013)
- Norberto Serpente
T-cell–B-cell cooperation
- N. A. Mitchison
Nature Reviews Immunology (2004)
- N. A. Mitchison
A pharmacologic study of the relationship between lymphocyte function and surface antigen expression
- M. L. Bliven
- A. C. Cunningham
- I. G. Otterness
Agents and Actions (1988)