Transformation and Virus Growth by Murine Sarcoma Viruses in Human Cells (original) (raw)

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• Published: 31 January 1970

Nature volume 225, pages 458–459 (1970)Cite this article

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Abstract

IN the study of neoplastic transformation of human cells in culture, the quantitative systems so far described have used only the DNA-containing tumour viruses SV40 (ref. 1) and adenovirus type 12 (ref. 2). Various factors, both genetic3 and environmental4, influence the efficiency of transformation with these viruses. We describe here a quantitative transformation system using an RNA-containing tumour virus, murine sarcoma virus (MSV)5. The transformation of human cells by MSV is inefficient, but in optimal conditions (logarithmically growing cells and certain highly susceptible cell strains) both cell transformation and virus growth can be demonstrated.

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References

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Authors and Affiliations

1. Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland, 20014
   STUART A. AARONSON & GEORGE J. TODARO

Authors

1. STUART A. AARONSON
2. GEORGE J. TODARO

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AARONSON, S., TODARO, G. Transformation and Virus Growth by Murine Sarcoma Viruses in Human Cells.Nature 225, 458–459 (1970). https://doi.org/10.1038/225458a0

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• Received: 10 October 1969
• Revised: 12 December 1969
• Issue date: 31 January 1970
• DOI: https://doi.org/10.1038/225458a0

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