Accumulation of Chorio-retinotoxic Drugs in the Foetal Eye (original) (raw)

• Letter
• Published: 19 September 1970

Nature volume 227, pages 1257–1258 (1970)Cite this article

• 129 Accesses
• 93 Citations
• 9 Altmetric
• Metrics details

Abstract

USING whole body autoradiography1 we have found a selective accumulation and retention of certain drugs-in the eyes of mouse foetuses. These drugs are known to cause ocular damage in adult humans and experimental animals. The injury (toxic retinopathy), which is not seen in albino animals, has been related to the affinity of the drugs for the melanin structures of the eye2. The risk of foetal ocular damage appears to have been neglected in the past.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

• Purchase on SpringerLink
• Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

Similar content being viewed by others

References

1. Ullberg, S., Acta Radiol., Suppl., 118 (1954).
2. Potts, A. M., Invest. Ophthal., 1, 522 (1962).
   CAS PubMed Google Scholar
3. Goar, E. L., and Fletcher, M. C., Amer. J. Ophthalmol., 42, 253 (1956).
   Article Google Scholar
4. Weekley, R. D., Potts, A. M., Reboton, J., and May, R. H., Arch. Ophthalmol., 64, 65 (1960).
   Article CAS Google Scholar
5. Hobbs, H. E., Sorsby, A., and Freedman, A., Lancet, ii, 478 (1959).
6. Burns, C. A., Amer. J. Ophthalmol., 66, 825 (1968).
   Article CAS Google Scholar
7. McFarlane, J. R., Yanoff, M., and Scheie, H. G., Arch. Ophthalmol., 76, 532 (1966).
   Article CAS Google Scholar
8. Bernstein, H. N., and Ginsberg, J., Arch. Ophthalmol., 71, 238 (1964).
   Article CAS Google Scholar
9. Greiner, A. C., and Berry, K., Canad. Med. Assoc. J., 90, 663 (1964).
   CAS Google Scholar
10. Szent-Györgyi, A., Introduction to a Submolecular Biology (Academic Press, New York, 1960).
    Google Scholar

Download references

Author information

Authors and Affiliations

1. Department of Toxicology, University of Uppsala, Uppsala, Sweden
   S. ULLBERG, N. G. LINDQUIST & S. E. SJÖSTRAND

Authors

1. S. ULLBERG
   You can also search for this author inPubMed Google Scholar
2. N. G. LINDQUIST
   You can also search for this author inPubMed Google Scholar
3. S. E. SJÖSTRAND
   You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

ULLBERG, S., LINDQUIST, N. & SJÖSTRAND, S. Accumulation of Chorio-retinotoxic Drugs in the Foetal Eye.Nature 227, 1257–1258 (1970). https://doi.org/10.1038/2271257a0

Download citation

• Received: 31 March 1970
• Revised: 11 June 1970
• Issue Date: 19 September 1970
• DOI: https://doi.org/10.1038/2271257a0

This article is cited by