T Cell-dependent Mediator in the Immune Response (original) (raw)

• Letter
• Published: 08 June 1973

Nature volume 243, pages 356–357 (1973)Cite this article

• 60 Accesses
• 38 Citations
• Metrics details

Abstract

SUPERNATANTS of allogeneic lymphocyte cultures enable bone-marrow derived (lymphocytes) to respond to sheep red blood cells (SRBC) _in vitro_1–3. It was suggested that a non-specific T cell-dependent mediator may be involved in the normal immune response to this antigen. Indeed, T cells educated to one erythrocyte antigen can, in the presence of that antigen, greatly facilitate the response of B cells to other non-cross reacting erythrocytes4,5. T cells educated to protein antigens can also generate such a non-specific event in the interaction of T and B cells _in vitro_6. The following experiments were designed to establish whether in this syngeneic system the phenomenon was dependent on the production of soluble mediators after activation of T cells by protein antigen.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

• Purchase on SpringerLink
• Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

Similar content being viewed by others

References

1. Schimpl, A., and Wecker, E., Nature New Biology, 237, 15 (1972).
   Article CAS Google Scholar
2. Feldmann, M., and Basten, A., J. Exp. Med., 136, 722 (1972).
   Article CAS Google Scholar
3. Hartmann, K. U., J. Exp. Med., 133, 1325 (1971).
   Article CAS Google Scholar
4. Hunter, P., Munro, A., and McConnell, I., Nature, 236, 52 (1972).
   Article CAS Google Scholar
5. Waldmann, H., Munro, A., and Hunter, P., Europ. J. Immunol., 3, 167 (1973).
   Article Google Scholar
6. Marbrooke, J., Lancet, ii, 1279 (1967).
   Article Google Scholar
7. Feldmann, M., and Basten, A., Nature New Biology, 237, 12 (1972).
   Article Google Scholar
8. Mishell, R. I., and Dutton, R. W., J. Exp. Med., 126, 423 (1967).
   Article CAS Google Scholar
9. Click, R. E., Benck, L., and Alter, B. J., Cell. Immunol., 3, 264 (1972).
   Article CAS Google Scholar
10. Golub, E. S., Cell. Immunol., 2, 353 (1971).
    Article CAS Google Scholar
11. Feldmann, M., J. Exp. Med., 136, 757 (1972).
    Google Scholar
12. Gery, I., and Waksman, B. H., J. Exp. Med., 136, 143 (1972).
    Article CAS Google Scholar
13. Katz, D. H., Paul, W. E., Goidl, E. A., and Benacerraf, B., J. Exp. Med., 133, 169 (1971).
    Article CAS Google Scholar
14. Osborne, jun., D. P., and Katz, D. H., J. Exp. Med., 136, 439 (1972).
    Article CAS Google Scholar
15. Ordal, J. C., and Grumet, F. C., J. Exp. Med., 136, 1195 (1972).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

1. Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge
   H. WALDMANN & A. MUNRO

Authors

1. H. WALDMANN
   You can also search for this author inPubMed Google Scholar
2. A. MUNRO
   You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

WALDMANN, H., MUNRO, A. T Cell-dependent Mediator in the Immune Response.Nature 243, 356–357 (1973). https://doi.org/10.1038/243356a0

Download citation

• Received: 11 December 1972
• Issue Date: 08 June 1973
• DOI: https://doi.org/10.1038/243356a0

This article is cited by