Chimaeras Obtained by Aggregation of Mouse Eggs with Rat Eggs (original) (raw)

• Letter
• Published: 01 June 1973

Nature volume 243, pages 472–473 (1973)Cite this article

• 153 Accesses
• 30 Citations
• 6 Altmetric
• Metrics details

Abstract

TECHNIQUES have been developed which enable mouse eggs differing in age and stage of development to aggregate and form large but apparently morphologically normal blastocysts capable of egg cylinder formation at least1,2. Such chronological regulation has also been demonstrated for the mouse blastocyst by transfer of an isolated 4.5-day inner cell mass to a 3.5-day blastocyst with the subsequent formation of a normal chimaera3. These systems show that chimaeras derived from two components with the same pattern of differentiation, but with a temporal discrepancy experimentally imposed, can develop normally. This suggests that rat and mouse eggs, in which the pattern of differentiation is similar but on a different time scale, might develop successfully when aggregated together. This hypothesis was supported by a pilot study4 which has been extended and is reported here.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

• Purchase on SpringerLink
• Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

Similar content being viewed by others

References

1. Stern, M. S., and Wilson, I. B., J. Embryol. Exp. Morph., 28, 247 (1972).
   CAS PubMed Google Scholar
2. Stern, M. S., J. Embryol. Exp. Morph., 28, 255 (1972).
   CAS PubMed Google Scholar
3. Gardner, R. L., Adv. Biosci., 6, 279 (1971).
   Google Scholar
4. Stern, M. S., thesis, Univ. Wales (1972).
5. Whittingham, D. G., J. Reprod. Fert. Suppl., 14, 7 (1971).
   CAS Google Scholar

Download references

Author information

Authors and Affiliations

1. Department of Zoology, University College of North Wales, Bangor, Caernarvonshire
   M. SUSAN STERN

Rights and permissions

About this article

Cite this article

STERN, M. Chimaeras Obtained by Aggregation of Mouse Eggs with Rat Eggs.Nature 243, 472–473 (1973). https://doi.org/10.1038/243472a0

Download citation

• Received: 01 February 1973
• Revised: 25 February 1973
• Published: 01 June 1973
• Issue date: 22 June 1973
• DOI: https://doi.org/10.1038/243472a0

This article is cited by