Immunological destruction of herpes simplex virus I infected cells (original) (raw)
- Letter
- Published: 11 October 1974
Nature volume 251, pages 542–543 (1974)Cite this article
Abstract
THERE are clearly two levels at which the immune response may intervene to induce protection against viral infection. Neutralising antibodies effectively limit spread of free virus in many situations, thus preventing reinfection. In a number of viral diseases, however, it is often not possible to cure the infection by even high titres of neutralising antibodies1,2. In such situations, recovery from infection may require the intervention of a cell-mediated immune response directed at the infected cell. Selective impairment of the host's immunity, for example, by thymectomy or by antilymphocyte serum, markedly increased mortality of mice infected with ectromelia3, and herpes simplex4,5. Macrophage suppression has had a similar effect6. In these cases recovery could be conferred by transfer of immune lymphoid cells (ref. 7 and B.R-Z., and A. C. Allison, unpublished). But the nature of the cells involved, and the mechanisms by which they act remain problematic. Our experiments were undertaken to evaluate the contribution of various types of cells to immune reactivity to cells infected with herpes simplex virus I in vitro.
This is a preview of subscription content, access via your institution
Access options
Additional access options:
Similar content being viewed by others
References
- Allison, A. C., Ann. Inst. Pasteur, 123, 585–608 (1972).
CAS Google Scholar - Brier, A. M., Wohlenberg, C., Rosenthal, J., Mase, M., and Notkins, A. C., Proc. natn. Acad. Sci., U.S.A., 68, 3073 (1971).
Article ADS CAS Google Scholar - Blanden, R. V., J. exp. Med., 132, 1035–1054 (1971).
Article Google Scholar - Nahmias, A. J., Hirsch, M. S., Kramer, J. H., and Murphy, F. A., Proc. Soc. exp. Biol. Med., 132, 696–698 (1969).
Article CAS Google Scholar - Mori, R., Tasaki, T., Kimura, G., and Takeya, K., Arch. ges. Virusforsch., 21, 459–462 (1967).
Article CAS Google Scholar - Zisman, B., Hirsch, M. S., and Allison, A. C., J. Immun., 104, 1155–1159 (1970).
CAS PubMed Google Scholar - Blanden, R. V., J. exp. Med., 133, 1074–1104 (1971).
Article CAS Google Scholar - Perlmann, P., and Holm, G., Adv. Immun., 2, 117–193 (1969).
Article Google Scholar - MacLennan, I. C. M., Transplant Rev., 13, 67–90 (1972).
CAS PubMed Google Scholar - Evans, R., and Alexander, P., Nature, 236, 168–170 (1972).
Article ADS CAS Google Scholar - Lodmell, D. L., Niwa, A., and Notkins, A. L., J. exp. Med., 137, 706–720 (1973).
Article CAS Google Scholar - Rabinowitz, S. G., and Proctor, R. A., J. Immun., 112, 1070–1077 (1974).
CAS PubMed Google Scholar - Cole, G. A., Nathanson, N., Prendergast, R. A., Nature, 238, 335–337 (1972).
Article ADS CAS Google Scholar - Glasgow, L. A., Arch. int. Med., 126, 125–134 (1970).
Article CAS Google Scholar - Green, J. A., Cooperband, S. R., and Kibrick, S., Science, 164, 1415–1417 (1969).
Article ADS CAS Google Scholar - Boyum, A., Scand. J. clin. Lab. Invest., 21, 77–90 (supplement 97), (1968).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Departments of Microbiology and Immunology and Cell Biology, Albert Einstein College of Medicine, Bronx, New York, 10461
BRACHA RAGER-ZISMAN & BARRY R. BLOOM
Authors
- BRACHA RAGER-ZISMAN
You can also search for this author inPubMed Google Scholar - BARRY R. BLOOM
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
RAGER-ZISMAN, B., BLOOM, B. Immunological destruction of herpes simplex virus I infected cells.Nature 251, 542–543 (1974). https://doi.org/10.1038/251542a0
- Received: 10 May 1974
- Issue Date: 11 October 1974
- DOI: https://doi.org/10.1038/251542a0
This article is cited by
Complement, viruses, and virus-infected cells
- Neil R. Cooper
- Glen R. Nemerow
Springer Seminars in Immunopathology (1983)