Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis (original) (raw)

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• Published: 11 October 1974

Nature volume 251, pages 547–548 (1974)Cite this article

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Abstract

THE cytotoxic activity1,2 of immune thymus-derived lymphocytes (T cells) for 51Cr-labelled fibroblasts, or macrophages infected with lymphocytic choriomeningitis (LCM) virus is restricted by the H-2 gene complex3,4. Specific lysis of LCM-infected monolayer cultures occurs only when targets and overlaying, sensitised T cells share at least one set of H-2 antigenic specificities.

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References

1. Zinkernagel, R. M., and Doherty, P. C., Scand. J. Immun. (in the press).
2. Doherty, P. C., Zinkernagel, R. M., and Ramshaw, I. A., J. Immun., 112, 1548–1552 (1974).
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3. Zinkernagel, R. M., and Doherty, P. C., Nature, 248, 701–702 (1974).
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Authors and Affiliations

1. Department of Microbiology, The John Curtin School of Medical Research, Canberra, A.C.T., Australia
   ROLF M. ZINKERNAGEL & PETER C. DOHERTY

Authors

1. ROLF M. ZINKERNAGEL
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2. PETER C. DOHERTY
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ZINKERNAGEL, R., DOHERTY, P. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis.Nature 251, 547–548 (1974). https://doi.org/10.1038/251547a0

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• Received: 24 June 1974
• Revised: 19 August 1974
• Issue Date: 11 October 1974
• DOI: https://doi.org/10.1038/251547a0