Antibody-dependent cell-mediated damage to schistosomula in vitro (original) (raw)

Nature volume 252, pages 503–505 (1974)Cite this article

Abstract

ANTIBODY-DEPENDENT cell-mediated cytotoxic effects have been described in many in vitro models involving single-cell suspensions of mammalian or avian target cells, and could be important in the rejection of tumours and allografts1–6. Similar responses could also be involved in protective immunity against metazoan parasites, and evidence for cell-mediated effector mechanisms of various types has emerged from work on _Nippostrongylus braziliensis_7 and _Litomosoides carinii_8 in rats. Here we present two new aspects of cell-mediated responses to metazoan parasites. First, we have adapted the 51Cr-release technique to assay damage to schistosomula of Schistosoma mansoni in vitro. Second, we provide evidence that normal human peripheral blood leukocytes, in the presence of sera from patients infected with S. mansoni, can damage labelled schistosomula in the absence of added complement.

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Authors and Affiliations

  1. Wellcome Trust Research Laboratories, PO Box 43640, Nairobi
    A. E. BUTTERWORTH, R. F. STURROCK & V. HOUBA
  2. Department of Medicine, University of Nairobi, Nairobi, Kenya
    P. H. REES

Authors

  1. A. E. BUTTERWORTH
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  2. R. F. STURROCK
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  3. V. HOUBA
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  4. P. H. REES
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BUTTERWORTH, A., STURROCK, R., HOUBA, V. et al. Antibody-dependent cell-mediated damage to schistosomula in vitro.Nature 252, 503–505 (1974). https://doi.org/10.1038/252503a0

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