Turnover of junctional and extrajunctional acetylcholine receptors of the rat diaphragm (original) (raw)
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- Published: 01 February 1975
Nature volume 253, pages 643–644 (1975)Cite this article
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Abstract
THE junctional acetylcholine receptors on the motor end-plate mediate the transmission of nerve impulses to skeletal muscle, and their number per endplate is normally kept constant at 1.4–4.7×107 for various vertebrate muscles1–4. In some conditions, as in rats chronically treated with neostigmine5,6 or in myasthenia gravis6, the number of acetylcholine receptors is markedly decreased; whereas, like denervation, insufficiency of neuromuscular transmission caused by various blocking agents, such as hemicholiniurn-3 and β bungarotoxin, tends to increase the number of receptors both at end-plate and non–end-plate zones (C. C. C., S. T. Chuang and M. C. H., unpublished). We, therefore, examined the turnover of acetylcholine receptors at end-plate and non–end-plate zones (extrajunctional) to shed more light on the pathophysiology of skeletal muscle.
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References
- Miledi, R., and Potter, L. T., Nature, 233, 599 (1971).
Article ADS CAS Google Scholar - Barnard, E. A., Wieckowski, J., and Chiu, T. H., Nature, 234, 207 (1971).
Article ADS CAS Google Scholar - Fambrough, D. M., and Hartzell, H. C., Science, 176, 189 (1972).
Article ADS CAS Google Scholar - Chang, C. C., Chen, T. F., and Chuang, S. T., Br. J. Pharmac., 47, 147 (1973).
Article CAS Google Scholar - Chang, C. C., Chen, T. F., and Chuang, S. T., J. Physiol., Lond., 230, 613 (1973).
Article CAS Google Scholar - Fambrough, D. M., Drachman, D. B., and Satyamurti, S., Science, 182, 293 (1973).
Article ADS CAS Google Scholar - Chang, C. C., and Lee, C. Y., Archs. int. Phamacodyn. Ther., 144, 241 (1963).
CAS Google Scholar - Chang, C. C., and Tung, L. H., Eur. J. Pharmac., 26, 386 (1974).
Article CAS Google Scholar - Chang, C. C., Chen, T. F., and Lee, C. Y., J. Pharmac. exp. Ther., 184, 339 (1973).
CAS Google Scholar - Berg, D. K., and Hall, Z. W., Science, 184, 473 (1974).
Article ADS CAS Google Scholar
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Authors and Affiliations
- Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, 100, Republic of China
C. C. CHANG & M. C. HUANG
Authors
- C. C. CHANG
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CHANG, C., HUANG, M. Turnover of junctional and extrajunctional acetylcholine receptors of the rat diaphragm.Nature 253, 643–644 (1975). https://doi.org/10.1038/253643a0
- Received: 08 November 1974
- Revised: 16 December 1974
- Published: 01 February 1975
- Issue Date: 20 February 1975
- DOI: https://doi.org/10.1038/253643a0