Turnover of junctional and extrajunctional acetylcholine receptors of the rat diaphragm (original) (raw)

Nature volume 253, pages 643–644 (1975)Cite this article

Abstract

THE junctional acetylcholine receptors on the motor end-plate mediate the transmission of nerve impulses to skeletal muscle, and their number per endplate is normally kept constant at 1.4–4.7×107 for various vertebrate muscles1–4. In some conditions, as in rats chronically treated with neostigmine5,6 or in myasthenia gravis6, the number of acetylcholine receptors is markedly decreased; whereas, like denervation, insufficiency of neuromuscular transmission caused by various blocking agents, such as hemicholiniurn-3 and β bungarotoxin, tends to increase the number of receptors both at end-plate and non–end-plate zones (C. C. C., S. T. Chuang and M. C. H., unpublished). We, therefore, examined the turnover of acetylcholine receptors at end-plate and non–end-plate zones (extrajunctional) to shed more light on the pathophysiology of skeletal muscle.

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Authors and Affiliations

  1. Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, 100, Republic of China
    C. C. CHANG & M. C. HUANG

Authors

  1. C. C. CHANG
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  2. M. C. HUANG
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CHANG, C., HUANG, M. Turnover of junctional and extrajunctional acetylcholine receptors of the rat diaphragm.Nature 253, 643–644 (1975). https://doi.org/10.1038/253643a0

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